瑞香狼毒化学成分研究

从瑞香狼毒95%乙醇提取物中分离得到了17个化合物,根据理化性质和波谱数据鉴定为4’-甲氧基-7-羟基黄酮(1),山奈酚(2),5,4’-二羟基-7-甲氧基二氢黄酮(3),4’,5,7-三羟基黄烷酮(4),3,5,7-三羟基黄烷酮(5),山奈酚-7-O-β-D-葡萄糖苷(6),α-香树酯醇(7),(24R)-5α-豆甾-7,22(E)-二烯-3α-醇(8),狼毒色原酮(9),伞形花内酯(10),东莨菪素(11),异东莨菪素(12),狼毒素(13),瑞香内酯(14),异茴芹香豆素(15),β-谷甾醇(16),瑞香素乙(17)和β-胡萝卜甙(18)。其中化合物1-8为首次从该植物中分离得到。     

毛瑞香酚性成分研究

应用色谱技术从毛瑞香根的乙醇提取物中分离和纯化出6个酚性成分,通过光谱方法鉴定其分别为瑞香醇酮(1)、西瑞香素-7-O-葡萄糖苷(2)、芫花苷(3)、瑞香黄烷D1(4)、瑞香黄烷现(5)和紫丁香苷(6)。6个化合物均为首次从该植物中分得。     

瑞香狼毒地上部分化学成分的研究

采用多种色谱技术,对瑞香狼毒(Stellera chamaejasme L.)地上部分脂溶性部位的化学成分进行了研究,分离得到11种化合物,结合理化性质和波谱分析,其结构分别鉴定为:1-亚油酸-棕榈酸-甘油酯(1),亚麻酸(2),亚油酸(3),β-谷甾醇(4),亚麻酸乙酯(5),西瑞香素(6),异新狼毒素A(7),丙二酸单乙酯(8),伞形花内酯(9),新狼毒素B(10)和龙胆酸(11)。其中,化合物1、8和11为首次从该植物中分离得到。     

金边瑞香有机相提取物库的构建及活性成分分离纯化研究

采用逆流提取-系统溶剂组分化-高效液相色谱法(high-performance liquid chromatography,HPLC)检测组分化效果-高速逆流色谱技术(High-Speed Counter-Current Chromatography,HSCCC)分离制备高纯度化合物的研究思路,对金边瑞香化学成分进行研究得到4个高纯度单体化合物.通过现代谱学方法分别鉴定为:瑞香素(daphnetin,1)、瑞香黄烷I(daphnodorin I,2)、对羟基苯甲酸(p-hydroxybenzonic acid,3)和瑞香黄烷D1(daphnodorin D1,4),化合物2～4均为首次从该种植物中分离得到.     

唐古特瑞香的化学成分研究

从唐古特瑞香(Daphne tangutica Maxim)95%乙醇提取物石油醚部分分离得到14个化合物,通过波谱学方法鉴定为β-谷甾醇(1)、β-胡萝卜苷(2)、2,4-二羟基-3,6-二甲基苯甲酸甲酯(3)、蛇床子素(4)、植物醇(5)、软脂酸(6)、stigmast-5-ene-3β,7α-diol(7)、(-)-lariciresinol(8)、daphnetin(9)、daphnoretin(10)、(-)-丁香树脂醇(11)、( )-medioresinol(12)、daphnelicin(13)和咖啡酸二十二酯(14)。     

瑞香狼毒根中的一个新化合物(英文)

从瑞香狼毒根中分离得到了7个化合物,根据理化性质和波谱数据鉴定为:3-丁酰基-4-氨基肉桂酸乙酯(1)、阿魏酸(2)、香草酸(3)、姜黄素(4)、5'-去甲氧基-姜黄素(5)、3'-羟基-4'-O-β-D-葡萄糖苷黄酮(6)、3-甲氧基-4-O-β-D-葡萄糖苯甲酸(7),其中化合物1~3,6~7为首次从该植物中分离得到,化合物1为新化合物。     

了哥王茎皮化学成分研究

从瑞香科荛花属植物了哥王(Wikstroemia indica)的茎皮中分离鉴定出5种化合物,其结构分别为西瑞香素(1)、芫花素(2)、槲皮素(3)、杨梅素(4)、山奈酚(5)。化合物3、4、5为首次从该植物中分离得到。     

抱茎苦荬菜水溶性成分的分离与结构鉴定

从抱茎苦荬菜的水溶性成分分离得到5个化合物,根据理化性质和光谱数据分别鉴定为木犀草素-7-O-β-D-葡萄糖醛酸苷(1),木犀草素-7-O-β-D-葡萄糖1→2葡萄糖苷(2),芹菜素-7-O-β-D-葡萄糖醛酸苷(3),菊苣酸(4),(-)3,4-二羟基咖啡酰基酒石酸(5)。化合物3～5为首次从该植物中分离得到。     

瑞香狼毒化学成分的研究北大核心CSCD

采用硅胶、反相RP．18、SephadexLH-20凝胶和制备HPLC色谱技术对瑞香狼毒（StellerachamaejasmeL．）根的化学成分进行分离和纯化。通过核磁、质谱等方法鉴定了其中18个化合物：去甲络石苷元（1）,异落叶松脂素（2）,（＋）-开环异落叶松树脂酚（3）,豆甾4．烯-3,6-二酮（4）,rel-（-）-（3R,3’R,4R,4’R）-6,6＇-dimethoxy-[3,3＇-blchroman]-4,4＇-diol（5）,methyl3-（2-hydroxy-4-（（7-hydmxy-6-methoxy-2-oxo-2H—ehromen-3-y1）oxy）phen-y1）pmpanoate（6）,狼毒素A（7）,异狼毒素B（8）,狼毒素B（9）,雁皮素A（10）,异雁皮素A（11）,狼毒色原酮（12）,mohsenone（13）,丁香酸（14）,二氢瑞香素乙（15）,西瑞香索（16）,β-谷甾醇（17）,3,4,5-三甲氧基苯甲酸（18）。其中化合物1—6均为首次从该植物中分离得到。     

蒙药材瑞香狼毒的化学成分研究

采用溶剂提取及柱色谱等方法,首次对瑞香狼毒Stellera chamaejasme L.的正丁醇萃取部位进行系统研究,分离得到6个苯丙素类化合物,并运用UV、1H NMR、13C NMR等现代波谱技术依次鉴定为伞形花内酯7-O-β-D-吡喃木糖(1→6)-β-D-吡喃葡萄糖苷(1),芥子醇1,3’-双-O-β-D-吡喃葡萄糖苷(2),紫丁香苷(3),(+)-落叶松树脂醇4,4’-O-β-D-吡喃葡萄糖苷(4),(+)-松树脂醇4,4’-O-双-β-D-吡喃葡萄糖苷(5)和(+)-丁香树脂醇-双-O-β-D-吡喃葡萄糖苷(6)。其中,化合物4、6为首次从该药材中分离得到。     

Prolyl endopeptidase inhibitors from Syzygium samarangense (Blume) Merr. & L. M. Perry

Compounds isolated from the hexane extract of the leaves of Syzygium samarangense (Blume) Merr. & L. M. Perry were tested for inhibitory activity against the following serine proteases: trypsin, thrombin and prolyl endopeptidase. The compounds were identified as an intractable mixture of alpha-carotene and beta-carotene (1), lupeol (2), betulin (3), epi-betulinic acid (4), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (5), 2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone (6), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (7), 2',4'-dihydroxy-6'-methoxy-3'-methyldihydrochalcone (8) and 7-hydroxy-5-methoxy-6,8-dimethylflavanone (9). Hydrogenation of compounds 5, 6 and 7 yielded compound 8, 2'-hydroxy-4',6'-dimethoxy-3'-methyldihydrochalcone (10) and 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyldihydrochalcone (11), respectively. The hydrogenated products of compounds 6 and 7 were also tested for enzyme inhibitory activity. In addition, beta-sitosterol (12) and beta-D-sitosterylglucoside (13) were also isolated. This is the first report of the isolation of compounds 1-6, 8 and 13 from this plant. Compounds 3-8 and 10 exhibited significant and selective inhibition against prolyl endopeptidase among three serine proteases. This is the first report of this kind of activity for all these compounds.     

艾纳香黄酮类化学成分的研究(英文)

从艾纳香(Blumea balsamiferaDC.)的地上部分中分离得到13个黄酮类化合物,经鉴定分别为5,7-二羟基-3,3′,4′-三甲氧基黄酮(1),3,5,3′,4′-四羟基-7-甲氧基黄酮(2),4,2′,4′-三羟基双氢查尔酮(3),儿茶素(4),阿亚黄素(5),davidioside(6),二氢槲皮素-7,4′-二甲醚(7),艾纳香素(8),二氢槲皮素-4′-甲醚(9),3,5,3′-三羟基-7,4′-二甲氧基黄酮(10),5,7,3′,5′-四羟基二氢黄酮(11),木犀草素(12),槲皮素(13)。其中化合物1和3~6为首次从该植物中分离得到。     

地菍的化学成分(英文)

为了研究野牡丹科药用植物地菍(Melastoma dodecandrum)的化学成分,采用柱层析方法分离鉴定了15个化合物,通过波谱分析及对比文献等方法鉴定为4-O-β-D-吡喃葡萄糖基-3,3',4'-三甲氧基鞣花酸(1),槲皮素3-O-刺槐二糖苷(2),8-C-吡喃葡萄糖基-5,7,3',4'-四羟基黄酮(3),3-O-β-D-吡喃葡萄糖基-4',5,7-三羟基黄酮(4),6-C-吡喃葡萄糖基-4',5,7-三羟基黄酮(5),3-hydroxy-22(29)-hopen-23-oic acid(6),2,3-dihydroxy-9(11)-fernen-23-oic acid(7),3β-sitosterol laminaribioside(8),姜糖酯B(9),3-O-β-D-galactopyranoside-glycerol1-alkanoates(10),胡萝卜苷(11),β-谷甾醇(12),二十八烷醇(13),二十四烷酸(14)以及三十四烷(15)化合物结构。所有化合物均为首次从该植物中分离得到。     

Benzofurans and another constituent from seeds of Styrax officinalis

The benzofuran constituents of the seeds of Styrax officinalis were investigated. From the hexane extract, two new constituents named 5-(3"benzoyloxypropyl)-7-methoxy-2-(3',4'-methylenedioxyphenyl)-benzofuran (5) and 4-[3"-(1c-methylbutanoyloxy)propyl]-2-methoxy-(3',4'-methylenedioxyphenyl)-1a, 5b-dihydrobenzo-[3,4]-cyclobutaoxirene (6) were isolated together with four known compounds, 5-[3"-(1c-methylbutanoyloxy)propyl]-7-methoxy-2-(3',4'-dimethoxyphenyl)-benzofuran (4), 5-[3"-(1c-methylbutanoyloxy)propyl]-7- methoxy-2-(3',4'-methylenedioxyphenyl)-benzofuran (3), 5-(3"-acetoxypropyl)-7-methoxy2-(3',4'-methylenedioxphenyl)-benzofuran (2) and 5-(3"-hydroxypropyl)-7-methoxy-2-(3',4'-met hylenedioxyphenyl)-benzofuran (1). Although the compounds 1, 2, and 3 have been isolated previously from the seeds of Styrax obassia, this is the first record of their isolation from seeds of Styrax officinalis. The structures of the isolated compounds were established by 1D- and 2D-NMR (HMBC, HMQC, COSY), FABMS and high-resolution ESI FTMS.     

Natural PTP1B inhibitors from Broussonetia papyrifera

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.     

Flavonoids from Andrographis lineata

Three flavonoids, 5,7,2',3',4'-pentamethoxyflavone (1), 2'-hydroxy-2,4',6'-tri methoxychalcone (2) and dihydroskullcapflavone I (3), together with 17,19,20-trihydroxy-5beta, 8alpha H, 9beta H,10alpha-labd-13-en-16,15-olactone (4), a known diterpenoid and six known flavonoids, 5-hydroxy-7,8-dimethoxyflavanone (5), 5-hydroxy-7,8,2',3',4'-pentamethoxyflavone (6), 5,2'-dihydroxy-7-methoxyflavanone (7), 5,2'-dihydroxy-7,8-dimethoxyflavone (8), 5,2'-dihydroxy-7-methoxyflavone (9) and 5,2'-dihydroxy-7-methoxyflavone 2'-O-beta-D-glucopyranoside (10) were isolated from the whole plant of Andrographis lineata. The structures of these compounds were elucidated on the basis of spectral and chemical studies.     

Iridoid glucosides and flavones from the aerial parts of Avicennia marina

Two new iridoid glucosides, namely, 2'-O-[(2E,4E)-5-phenylpenta-2,4-dienoyl]mussaenosidic acid (1; mussaenosidic acid = [1S-(1alpha,4aalpha,7alpha,7aalpha)]-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid) and 2'-O-(4-methoxycinnamoyl)mussaenosidic acid (2), were isolated from the aerial parts of the mangrove plant Avicennia marina. Beside that, one known iridoid glucoside, 2'-O-coumaroylmussaenosidic acid (3) and four known flavones (flavone = 2-phenyl-4H-1-benzopyran-4-one) including 4',5-dihydroxy-3',7-dimethoxyflavone (4), 4',5-dihydroxy-3',5',7-trimethoxyflavone (5), 4',5,7-trihydroxyflavone (6), and 3',4',5-trihydroxy-7-methoxyflavone (7) were also isolated and identified. The structures of these compounds were elucidated by NMR spectroscopy and by low- and high-resolution mass spectrometry. The chemotaxonomic significance of these findings was discussed. In addition, each isolated compound was evaluated for the ability of alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical-scavenging activity.     

Flavonoids, including an unusual flavonoid-Mg2+ salt, from roots of Cudrania cochinchinensis

Four flavonoids with 2',4'-di-oxygenated B-rings, cochinchinol A (1), cochinchinol B (2), (2R,3R)-4',7-dihydroxy-2',5-dimethoxydihydroflavonol (3), 4',7-dihydroxy-2',5-dimethoxyflavonol (4), along with 11 known compounds, were isolated from an ethanolic extract of the roots of Cudrania cochinchinensis. Their structures were elucidated by chemical and spectroscopic methods. Cochinchinol A (1) and cochinchinol B (2) have two hitherto unprecedented flavonol salt structures in natural product chemistry. Cytotoxic activities were evaluated against several different cell lines.     

An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels

Two sesquiterpene-trimethoxystyrene conjugates (E)-1-[3'-(4',8'-dimethylnona-3',7'-dienyl)cyclohex-3'-enyl]-2,4,5-trimethoxybenzene (1) and (Z)-1-[3'-(4',8'-dimethylnona-3',7'-dienyl)cyclohex-3'-enyl]-2,4,5-trimethoxybenzene (2), a phenylpropanoid 1,2,4-trimethoxy-5-(1-methoxy-ethyl)-benzene (3), and an aporphine alkaloid N-acetylpachypodanthine (4), were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts from bark of Pachypodanthium confine. The structures of these compounds were established based on the interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data.     

白木香树干中的黄酮类成分

从白木香[Aquilaria smensis(Lour.)Gilg]树干的乙醇提取物中分离得到5个黄酮类化合物,经波谱分析,分别鉴定为:洋芹素-7,4'-二甲醚(1)、5-羟基-7,3',4'-三甲氧基黄酮(2)、木犀草素-7,4'-二甲醚p)、芫花素(4)和4',5-二羟基-3',7-二甲氧基黄酮(5).以上化合物均为首次从该种植物树干中分离得到.