共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors 总被引:15,自引:0,他引:15
Göttgens B Nastos A Kinston S Piltz S Delabesse EC Stanley M Sanchez MJ Ciau-Uitz A Patient R Green AR 《The EMBO journal》2002,21(12):3039-3050
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
《Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms》2020,1863(8):194579
As demonstrated through early work in Drosophila, members of the MLL/SET family play essential roles during embryonic development through their participation in large protein complexes that are central to epigenetic regulation of gene expression. One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver in different types of leukaemia when aberrantly fused to a large variety of partners as a result of chromosomal translocations. Its exclusive association with cancers of the haematopoietic system has prompted a large number of investigations into the role of MLL/SET proteins in haematopoiesis, a summary of which was attempted in this review. Interestingly, MLL-rearranged leukaemias are particularly prominent in infant and paediatric leukaemia, which commonly initiate in utero. This, together with the known function of MLL/SET proteins in embryonic development, has focussed research efforts in recent years on understanding the role of this protein family in developmental haematopoiesis and how this may be subverted by MLL oncofusions in infant leukaemia. A detailed understanding of these prenatal events is essential for the development of new treatments that improve the survival specifically of this very young patient group. 相似文献
14.
15.
16.
17.
18.
19.
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin
Susanne V Schmidt Wolfgang Krebs Thomas Ulas Jia Xue Kevin Ba?ler Patrick Günther Anna-Lena Hardt Hartmut Schultze Jil Sander Kathrin Klee Heidi Theis Michael Kraut Marc Beyer Joachim L Schultze 《Cell research》2016,26(2):151-170