共查询到20条相似文献,搜索用时 15 毫秒
1.
Efferent and reciprocal synapses have been demonstrated in the carotid body of the domestic fowl (Gallus gallus domesticus). Synapses were also found with purely afferent morphology, but were probably components of reciprocal synapses. The general morphology of the endings suggested the presence of two types of axon, afferent axons making reciprocal and perhaps afferent synapses with Type I cells, and efferent axons making efferent synapses with Type I cells. A few axo-dendritic synapses were also found. The dense-cored vesicles associated with the afferent components of reciprocal synapses and with the possible true afferent synapses varied in diameter and core but could belong to one population of pre-synaptic vesicles. These observations are consistent wtih a new theory for the carotid body receptor mechanism. This proposes a spontaneously discharging afferent axon inhibited by an inhibitory transmitter substance released by the Type I cell via the "afferent" component of its reciprocal synapse, the "efferent" component inhibiting this release. Besides this chemoreceptor modulation of its afferent axon, the Type I cell may also have a general secretory function. 相似文献
2.
Otto E. Rössler 《Bulletin of mathematical biology》1978,40(1):45-58
For certain environments, the Darwinian model allows unique prediction of a function that any surviving system adapted to
such an environment has to perform. This is the case for those environments that determine a “survival functional” of position
in space-time of known shape. Purely temporal survival functionals can be distinguished from spatial and mixed ones. In each
case, there exists an optimum path in combined physical and (reduced) metabolic space. Dependent on the admissible error,
approximate solutions of different complexity are sufficient. All solutions possess an afferent, a central, and an efferent
part. Within this general frame, specific, “probably simplest”, solutions are proposed for adaptive chemotaxis, insect locomotion,
lower vertebrates locomotion, higher vertebrates locomotion, chronobiological systems, and immune systems, respectively—or
rather, for the underlying functionals.
Presented at the Society for Mathematical Biology Meeting, University of Pennsylvania, Philadelphia, August 19–21, 1976. 相似文献
3.
Gradual cooling of anesthetized rats followed by a drop in rectal temperature (RT) increased the frequency of efferent impulses
and decreased the frequency of afferent impulses in the vagus nerves. Preliminary short-lasting (5 h) moderate cooling of
the animals in a thermochamber to +5°C (RT did not change), or intensive cooling to −20°C (RT dropped to 32°C) changed the
response of efferent nerve fibers to cooling of the body. Under these conditions, a drop in RT to 29°C was followed by a significant
increase in efferent discharges in the vagus nerve after additional cooling throughout the experiment, while an initial cooling
phase (RT was equal to 35-30°C) was followed by some inhibitory effect. At the same time, the changes in the afferent link
were different. As in the control, gradual cooling decreased frequency of afferent impulses, although the intensity of the
effects was different. The involvement of the vagus nerve system in the maintenance of temperature homeostasis during body
cooling has been discussed. 相似文献
4.
Denton KM Anderson WP Sinniah R 《American journal of physiology. Regulatory, integrative and comparative physiology》2000,279(2):R629-R638
The diversity of renal arteriole diameters in different cortical regions has important consequences for control of glomerular capillary pressure. We examined whether intrarenal angiotensin II (ANG II; 0.1, 1, or 5 ng. kg(-1). min(-1)) in anesthetized rabbits acts preferentially on pre- or postglomerular vessels using vascular casting. ANG II produced dose-related reductions in afferent and efferent diameters in the outer, mid, and inner cortex, without effecting arterial pressure. Afferent diameter decreased more than efferent in the outer and mid cortex (P < 0.05) but by a similar extent in juxtamedullary nephrons (P = 0.58). Calculated efferent resistance increased more than afferent, especially in the outer cortex (127 vs. 24 units; 5 ng. kg(-1). min(-1) ANG II). ANG II produced significant dose-related increases in the distance between the arterioles at the entrance to the glomerular pole in all regions. Thus afferent diameter decreased more in response to ANG II, but efferent resistance rose more due to smaller resting luminal dimensions. The results also indicate that glomerular pole dimensions change in response to ANG II. 相似文献
5.
John A. Donald 《Journal of morphology》1989,200(1):37-46
The branchial vascular anatomy of Urolophus mucosus and U. paucimaculatus was studied by scanning electron microscopical examination of critical-point-dried tissue or of vascular corrosion casts. The vasculature could be divided into arterioarterial and arteriovenous pathways, which channel the flow of blood through the gills. The arterioarterial pathway consists of an afferent branchial artery which gives rise to afferent distributing arteries that run through the tissues of the interbranchial septum and supply the afferent filament arteries of several filaments. Afferent filament arteries open regularly into a corpus cavernosum in the core of the filament; unlike other elasmobranchs no septal corpora cavernosa are found. At the tip of the filament, channels of the corpus cavernosum connect to a channel which passes across the distal end of the filament from afferent to efferent side. This channel always connects to the afferent filament artery, and in many filaments it connects to the efferent filament artery as well. In addition, a vascular arcade connects all the afferent filament arteries along the entire length of each hemibranch. The filament corpus cavernosum supplies the secondary lamellae. The lamellae drain into efferent lamellar arterioles which in turn drain into the efferent filament artery and the efferent branchial artery. The vascular anatomy of the arteriovenous pathway is similar to that described in other elasmobranchs and consists of arteriovenous anastomoses, found only arising from efferent arterial circulation, and the venolymphatic system, which is composed of the central venous sinus and the companion vessels. 相似文献
6.
《Journal of Russian & East European Psychology》2013,51(2):13-28
An analogy is drawn between the functions of consciousness and the model of a reflex. Consciousness consists of an afferent part, which is the perception of the external world; a central part, which is thought; and an efferent part, which is a decision concerning an action and the transmission of a motor command. At the basis of higher mental functions lies the unification of reflexes into complexes; and within these complexes, key structures are differentiated that synthesize qualitatively disparate information. The centers of integration for the effectuation of the afferent and efferent functions of consciousness are located in the posterior and anterior sections of the brain, respectively. Predominantly afferent and efferent stages, with localized foci of interaction, may also be distinguished in thought. The communicative function of consciousness is realized primarily by centers in the left hemisphere. A discrepancy between the afferent and efferent functions of consciousness may underlie certain forms of mental pathology. 相似文献
7.
The epidermis on the backs or ears of DBA/2 mice treated for 7 days with a 20% concentration of monobenzyl ether of hydroquinone (MBEH) had a significantly greater population density of ATPase- and Ia-positive cells compared with control mice treated with diluent. There was no decrease or increase in ATPase- or Ia-positive cells at sites distal from the treated tissue. This increase in population density of Langerhans cells was associated with a significant increase in functional afferent immune reactivity measured by allergic contact hypersensitivity. We also found evidence for enhanced efferent immune reactivity. Animals treated on the ears for 7 days with MBEH were sensitized to DNFB on untreated back. MBEH treated ears with more Ia-positive Langerhans cells demonstrated a threefold greater increase in swelling after the DNFB challenge than the control mice. Results of other studies suggest that the afferent and efferent enhanced immune reactivity produced by MBEH are local effects. We postulated that MBEH produced its effects by activating the oxidation of arachidonic acid (AA) to prostaglandins. To test this, we applied AA to mouse skin. AA has a biphasic effect on epidermal Langerhans cells: in low doses it increases their number; in high amounts it decreases the number of identifiable cells with either the Ia or the ATPase technique. An increased population density of identifiable epidermal Langerhans cells induced with AA was correlated with an increase in afferent and efferent immune reactivity. In contrast, reduction of Langerhans cells with larger amounts of AA suppress the afferent and efferent limb of the immune response. DNFB applied to skin with decreased Langerhans cell density from AA induced a state that mimics immune tolerance. The findings are significant because we report the only method to either increase or decrease the population density of Langerhans cells: and to modulate up or down the afferent or efferent limbs of the cutaneous immune response. Our results also suggest that the Langerhans cell may be involved in the efferent limb of the immune efferent response. These effects may be modulated in part by products of AA metabolism. 相似文献
8.
Afferent lymphatics draining granulomas and efferent lymphatics from normal and stimulated lymph nodes were cannulated in sheep. There was a greatly increased output of cells in afferent lymph-draining chronic inflammatory sites or Freund's adjuvant-induced granulomas. Cells collected from these lymphatics were radiolabeled with 111In and injected intravenously. The reappearance of these labeled cells in lymph at various sites was measured. Labeled afferent lymph cells migrated from blood through the granuloma back into afferent lymph in large numbers and with kinetics which were comparable to efferent lymphocytes recirculating through a lymph node. When labeled afferent lymph cells were injected the specific activity (cpm/107 cells) in afferent lymph was five times higher than that in efferent lymph from a normal node. When efferent lymph cells were labeled the afferent lymph specific activity was one-half that in efferent lymph. It is suggested that the cells in afferent lymph migrate preferentially from blood through the granuloma and constitute a unique population of cells. 相似文献
9.
John Donald 《Journal of morphology》1984,182(3):307-316
The adrenergic innervation of structures in the gills of brown and rainbow trout was studied with catecholamine fluorescence histochemistry. In the arterio-arterial vascular pathway, there was an innervation of the afferent and efferent lamellar arterioles, but the afferent and efferent filamental arteries and the secondary lamellae were devoid of any fluorescent nerve fibres. In S. trutta only, there was an additional innervation of the afferent and efferent branchial arteries and the base of the efferent filamental artery. The innervation of the arterio-venous vascular pathway was similar in both trout species. Many fluorescent nerve fibres were found on nutritive arterioles in the gill arch and interbranchial septum, and in the core of each filament between the surface epithelium and the wall of the filament venous sinus. No fluorescent nerve fibres were observed at the origins of the capillaries arising from the efferent filamental artery. The sympathetic nerve supply is provided to the gills mainly through the posttrematic nerve, with an occasional small contribution through the pretrematic nerve. The presence of adrenergic nerves in the gills is discussed in relation to the regulation of blood flow through the arterio-arterial and arterio-venous pathways. 相似文献
10.
Acute experiments on rats showed that intraperitoneal administration of 5 μg/kg of a bacterial toxin (pyrogenal) increases
the afferent impulsation frequency in the cervical segments of vagus nerves, VN (multifiber recording), and frequency of the
multineuronal activity in the solitary tract nucleus (STN); these changes were observed during the whole period of recording
(10–160 min following toxin injection). Enhancement of the efferent impulsation in the VN and neuronal activity in the dorsal
nucleus of the vagus nerve (DNVN) could be observed only 120–130 min after toxin administration. Under these conditions rectal
temperature in experimental animals was 1.5° higher than that in control rats throughout the period of recording. Following
subdiaphragmatic vagotomy, the afferent impulsation frequency in the cervical VN decreased about four times and kept on decreasing
during the whole period of registration. Pyrogenal introduction evoked no changes in the direction of reactions to vagotomy.
Under these conditions, body temperature of these animals was 2.5°C higher than in control vagotomized rats by the final stage
of recording. Animal heating in a chamber caused no changes in the afferent impulsation frequency and resulted in a decrease
in the frequency of VN efferent discharges. Involvement of the VN in the maintenance of temperature homeostasis during fever
induced by the endotoxin action and by hyperthermia due to a rise in ambient temperature is discussed.
Neirofiziologiya/Neurophysiology, Vol. 32, No. 2, pp. 112–119, March–April, 2000. 相似文献
11.
A possibility of efferent innervation of gustatory and mechanosensitive afferent fiber endings was studied in frog fungiform papillae with a suction electrode. The amplitude of antidromic impulses in a papillary afferent fiber induced by antidromically stimulating an afferent fiber of glossopharyngeal nerve (GPN) with low voltage pulses was inhibited for 40 s after the parasympathetic efferent fibers of GPN were stimulated orthodromically with high voltage pulses at 30 Hz for 10 s. This implies that electrical positivity of the outer surface of papillary afferent membrane was reduced by the efferent fiber-induced excitatory postsynaptic potential. The inhibition of afferent responses in the papillae was blocked by substance P receptor blocker, L-703,606, indicating that substance P is probably released from the efferent fiber terminals. Slow negative synaptic potential, which corresponded to a slow depolarizing synaptic potential, was extracellularly induced in papillary afferent terminals for 45 s by stimulating the parasympathetic efferent fibers of GPN with high voltage pulses at 30 Hz for 10 s. This synaptic potential was also blocked by L-703,606. These data indicate that papillary afferent fiber endings are innervated by parasympathetic efferent fibers. 相似文献
12.
Brendan J Canning 《Journal of applied physiology》2006,101(3):971-985
Autonomic nerves in most mammalian species mediate both contractions and relaxations of airway smooth muscle. Cholinergic-parasympathetic nerves mediate contractions, whereas adrenergic-sympathetic and/or noncholinergic parasympathetic nerves mediate relaxations. Sympathetic-adrenergic innervation of human airway smooth muscle is sparse or nonexistent based on histological analyses and plays little or no role in regulating airway caliber. Rather, in humans and in many other species, postganglionic noncholinergic parasympathetic nerves provide the only relaxant innervation of airway smooth muscle. These noncholinergic nerves are anatomically and physiologically distinct from the postganglionic cholinergic parasympathetic nerves and differentially regulated by reflexes. Although bronchopulmonary vagal afferent nerves provide the primary afferent input regulating airway autonomic nerve activity, extrapulmonary afferent nerves, both vagal and nonvagal, can also reflexively regulate autonomic tone in airway smooth muscle. Reflexes result in either an enhanced activity in one or more of the autonomic efferent pathways, or a withdrawal of baseline cholinergic tone. These parallel excitatory and inhibitory afferent and efferent pathways add complexity to autonomic control of airway caliber. Dysfunction or dysregulation of these afferent and efferent nerves likely contributes to the pathogenesis of obstructive airways diseases and may account for the pulmonary symptoms associated with extrapulmonary disorders, including gastroesophageal reflux disease, cardiovascular disease, and rhinosinusitis. 相似文献
13.
W. A. Yuhas P. A. Fuchs 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1999,185(5):455-462
Acetylcholine released from efferent neurons in the cochlea causes inhibition of mechanosensory hair cells due to the activation
of calcium-dependent potassium channels. Hair cells are known to have large-conductance, “BK”-type potassium channels associated
with the afferent synapse, but these channels have different properties than those activated by acetylcholine. Whole-cell (tight-seal) and
cell-attached patch-clamp recordings were made from short (outer) hair cells isolated from the chicken basilar papilla (cochlea
equivalent). The peptides apamin and charybdotoxin were used to distinguish the calcium-activated potassium channels involved
in the acetylcholine response from the BK-type channels associated with the afferent synapse. Differential toxin blockade
of these potassium currents provides definitive evidence that ACh activates apamin-sensitive, “SK”-type potassium channels,
but does not activate carybdotoxin-sensitive BK channels. This conclusion is supported by tentative identification of small-conductance,
calcium-sensitive but voltage-insensitive potassium channels in cell-attached patches. The distinction between these channel
types is important for understanding the segregation of opposing afferent and efferent synaptic activity in the hair cell,
both of which depend on calcium influx. These different calcium-activated potassium channels serve as sensitive indicators
for functionally significant calcium influx in the hair cell.
Accepted: 12 August 1999 相似文献
14.
Carotid bodies of ducks show no detectable changes in ultrastructure up to periods of four weeks following the removal of 2-3 cm of the cervical vagus (decentralization). This indicates that the majority, and possibily all the nerves terminating on the glomus cells are afferent (sensory) in nature. These nerve endings are in reciprocal synaptic contact with the glomus cells and therefore have efferent and afferent functions. Theories concerning the carotid body receptor mechanism are discussed with particular reference to those theories which ascribe functions to the reciprocal synapses. 相似文献
15.
Seth M. Tomchik Zhongmin Lu 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(1):51-67
Vertebrate hair cell systems receive innervation from efferent neurons in the brain. Here we report the responses of octavolateral
efferent neurons that innervate the inner ear and lateral lines in a teleost fish, Dormitator latifrons, to directional linear accelerations, and compare them with the afferent responses from the saccule, the main auditory organ
in the inner ear of this species. Efferent neurons responded to acoustic stimuli, but had significantly different response
properties than saccular afferents. The efferents produced uniform, omnidirectional responses with no phase-locking. Evoked
spike rates increased monotonically with stimulus intensity. Efferents were more broadly tuned and responsive to lower frequencies
than saccular afferents, and efferent modulation of the otolithic organs and lateral lines is likely more pronounced at lower
frequencies. The efferents had wide dynamic ranges, shallow rate-level function slopes, and low maximum discharge rates. These
findings support the role of the efferent innervation of the otolithic organs as part of a general arousal system that modulates
overall sensitivity of the peripheral octavolateral organs. In addition, efferent feedback may help unmask biologically relevant
directional stimuli, such as those emitted by a predator, prey, or conspecific, by reducing sensitivity of the auditory system
to omnidirectional ambient noise. 相似文献
16.
The present model of joint angle perception is based on the following hypotheses: the perception and control of joint angle are closely interrelated processes; central motor commands are adequately expressed by shifts of an equilibrium point resulting from the interaction of antagonistic muscles and a load; two fundamental commands-reciprocal (r) and coactivative (c) provide for changes in activity of the antagonistic muscle pair. The dependence of joint angle on static muscle torque and r and c commands is derived (Eq. 5). The following principles of joint position sense are formulated: 1) the r component of the efferent copy plays the role of a reference point which shifts during voluntary regulation of muscle state, but remains unchanged during any passive alterations of joint position; 2) muscle afferent signals deliver not absolute but relative information (i.e. measured relatively to the central reference point). These signals turn out to be related to active muscle torque; 3) the nervous system evaluates muscle afferent signals on the basis of a scale determined by the level of coactivation of the antagonistic muscles. Kinaesthetic illusions appear to be due to disruptions in perception of afferent and/or efferent components of position sense. The present model is consistent with all the variety of kinaesthetic illusions observed experimentally. A qualitative neurophysiological schema for joint angle perception is proposed involving efferent copy and information concerning muscle torque delivered by the tendon organ, muscle spindle, and perhaps, articular receptors. It is known that the cerebellum incorporates both afferent and efferent information concerning movement. One may presume that it plays an essential role in position sense. 相似文献
17.
Abstract A detailed study of the structure of the heart and the general disposition of the efferent (arterial) vessels and afferent (venous) vessels is presented. The vascular system of P. hawaiensis is compared with that of other species of amphipods and the differences are pointed out. All the appendages except the pleopods receive their efferent vessels directly from the heart and not from the sternal sinus. 相似文献
18.
Kunihiko Fukushima 《Biological cybernetics》1986,55(1):5-15
A neural network model of the mechanism of selective attention in visual pattern recognition is proposed and simulated on a digital computer.When a complex figure consisting of two patterns or more is presented to the model, it is segmented into individual patterns, and each pattern is recognized separately. Even if one of the patterns to which the model is paying selective attention is affected by noise or defects, the model can recall the complete pattern from which the noise has been eliminated and the defects corrected. It is not necessary for perfect recall that the stimulus pattern should be identical in shape to the training pattern. Even though the pattern is distorted in shape or changed in size, it can be correctly recognized and the missing portions restored.The model consists of a hierarchical neural network which has efferent as well as afferent connections between cells. The afferent and the efferent signals interact with each other in the network: the efferent signals, that is, the signals for selective attention, have a facilitating effect on the afferent ones, and, at the same time, the afferent signals gate efferent signal flow. When some feature in the stimulus is not extracted in the afferent paths, the threshold for detection of that feature is automatically lowered by decreasing the efficiency of inhibition, and the model tries to extract even vague traces of the undetected feature. 相似文献
19.
A T Bianchi L M Hussaarts-Odijk E A Wolters A Molendijk R Benner 《Journal of immunology (Baltimore, Md. : 1950)》1986,137(2):433-442
Suppressor T (Ts) cells that can suppress delayed type hypersensitivity (DTH) against histocompatibility (H) antigens can be isolated from spleen and lymph nodes a few days after i.v. immunization of mice with irradiated allogeneic spleen cells. In this paper we investigated the suppression of the efferent phase of DTH to characterize the Ts cells involved, and to compare them with the afferent phase Ts cells that have been characterized in a previous paper of this series. The DTH against third party alloantigens that were not used for the i.v. suppressive immunization could be suppressed by presenting the third party alloantigens together with the original alloantigens in the challenge inoculum for eliciting the DTH reaction. Thus the ultimate suppressive effect by the Ts cells that are active during the efferent phase of DTH is nonspecific. This non-specific suppression of DTH to alloantigens has previously been found for the afferent phase Ts cells as well. For suppression of the efferent phase of DTH to alloantigens, a population of Lyt-1+2+ Ts cells appeared to be essential, just like in the suppression of the afferent phase of DTH to alloantigens. We did not find evidence for the involvement of cyclophosphamide-sensitive auxiliary Ts cells in suppression of the efferent phase of DTH. Also no evidence was found for H-2 or Igh-restricted activation and function of the Ts cells that were active during afferent and efferent phases of the DTH response to H antigens. In view of these similarities between afferent phase and efferent phase Ts cells we conclude that there are no arguments as yet to suppose that there is more than one type of T cells involved in the suppression of the afferent and efferent limb of DTH against H antigens. 相似文献
20.
The effects of beta-alanine on the electrically evoked vagal efferent (hexamethonium-sensitive initial excitatory response) and afferent (hexamethonium-resistant delayed excitatory response) responses of the cat stomach were studied. beta-alanine (30 to 300 micrograms/kg, i.v.) dose-dependently inhibited both the efferent and afferent response. The IC50 values of beta-alanine on the efferent and afferent response were 296 +/- 65 micrograms/kg and 128 +/- 35 microgram/kg, respectively. Maximal inhibitory effects of beta-alanine (300 micrograms/kg, i.v.) appeared about 1 hr after the injection. Glycine and taurine (100 to 10,000 micrograms/kg) did not affect these responses. Treatment with hexamethonium (10 mg/kg, i.v.) prevented the efferent response, but augmented the afferent response. The treatment with hexamethonium abolished the inhibitory effect of beta-alanine on the afferent response. Both picrotoxin (100 and 500 micrograms/kg, i.v.) and bicuculline (2000 micrograms/kg, i.v.) antagonized the inhibitory effects of beta-alanine on the vagal efferent and afferent responses of the stomach. The present experiments clearly demonstrated that beta-alanine inhibited both the vagal efferent and afferent excitatory responses of stomach to electrical stimulation of vagal trunk in cats. 相似文献