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The ETS-domain transcription factor family 总被引:2,自引:0,他引:2
Andrew D. Sharrocks A.Louise Brown Yan Ling Paula R. Yates 《The international journal of biochemistry & cell biology》1997,29(12):1371-1387
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Conservation and diversification of three-repeat Myb transcription factors in plants 总被引:1,自引:0,他引:1
Ito M 《Journal of plant research》2005,118(1):61-69
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Nan Li Min Li Wenxuan Hong Jing Shao Huihui Xu Hitoshi Shimano Jun Lu Yong Xu 《生物化学与生物物理学报:疾病的分子基础》2018,1864(9):2881-2889
Alteration of hepatic lipid metabolism contributes to a range of human diseases including steatosis. Sterol response element binding protein (SREBP) is the master regulator of lipid metabolism. The epigenetic mechanism whereby SREBP activity is regulated remains incompletely understood. We have previously shown that systemic knockdown of brahma-related gene 1 (Brg1), a chromatin remodeling protein, attenuates steatosis in mice by down-regulating the synthesis of pro-inflammatory mediators. Here we show that hepatocyte conditional Brg1 knockout (HepcKO) mice were largely protected from high-fat diet (HFD) induced steatosis as evidenced by decelerated weight gains, improved insulin sensitivity, ameliorated steatotic injuries, and diminished hepatic inflammation. Brg1 contributed to lipid metabolism by trans-activating the genes involved in fatty acid esterification. Mechanistically, Brg1 interacted with and was recruited by sterol response element binding protein (SREBP1c) to the promoters of SREBP target genes and optimized the chromatin structure to facilitate SREBP1c binding. Therefore, our data have identified a previously unrecognized role for Brg1 in hepatic lipid metabolism by portraying Brg1 as an essential epigenetic co-factor for SREBP1c. 相似文献
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Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit 总被引:1,自引:0,他引:1
Dal Cin V Tieman DM Tohge T McQuinn R de Vos RC Osorio S Schmelz EA Taylor MG Smits-Kroon MT Schuurink RC Haring MA Giovannoni J Fernie AR Klee HJ 《The Plant cell》2011,23(7):2738-2753
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Josefa Gómez‐Maldonado Isabelle Lesur Noe Fernández‐Pozo Marina Rueda‐López Dario Guerrero‐Fernández Vanessa Castro‐Rodríguez Hicham Benzekri Rafael A. Cañas María‐Angeles Guevara Andreia Rodrigues Pedro Seoane Caroline Teyssier Alexandre Morel François Ehrenmann Grégoire Le Provost Céline Lalanne Céline Noirot Christophe Klopp Isabelle Reymond Angel García‐Gutiérrez Jean‐François Trontin Marie‐Anne Lelu‐Walter Celia Miguel María Teresa Cervera Francisco R. Cantón Christophe Plomion Luc Harvengt Concepción Avila M. Gonzalo Claros Francisco M. Cánovas 《Plant biotechnology journal》2014,12(3):286-299