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Nakanishi N Abe H Ogura Y Hayashi T Tashiro K Kuhara S Sugimoto N Tobe T 《Molecular microbiology》2006,61(1):194-205
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S Metzger I B Dror E Aizenman G Schreiber M Toone J D Friesen M Cashel G Glaser 《The Journal of biological chemistry》1988,263(30):15699-15704
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The bacterial stringent response, conserved in chloroplasts, controls plant fertilization 总被引:1,自引:0,他引:1
Masuda S Mizusawa K Narisawa T Tozawa Y Ohta H Takamiya K 《Plant & cell physiology》2008,49(2):135-141
The chloroplast, an essential organelle for plants, performs a wide variety of metabolic processes for host cells, which include photosynthesis as well as amino acid and fatty acid biosynthesis. The organelle conserves many bacterial systems in its functions, implicating its origin from symbiosis of a photosynthetic bacterium. In bacterial cells, the stringent response acts as a global regulatory system for gene expression mediated by a small nucleotide, guanosine 5'-diphosphate 3'-diphosphate (ppGpp), that is necessary for cell adaptation to diverse environmental stimuli such as amino acid starvation. Recent studies indicated that proteins similar to the bacterial ppGpp synthase/hydrolyase are conserved in plants, although their precise roles are not known. Here we show that the stringent response in chloroplasts is crucial for normal plant fertilization. Specifically, one of the Arabidopsis ppGpp synthase homologs, CRSH (Ca(2+)-activated RelA/SpoT homolog), exhibits calcium-dependent ppGpp synthesis activity in vitro, and is localized in chloroplasts in vivo. A knockdown mutation of CRSH in Arabidopsis results in a significant reduction in silique size and seed production, indicating that plant reproduction is under the control of chloroplast function through a ppGpp-mediated stringent response. 相似文献
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Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci. 总被引:5,自引:4,他引:1
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The stringent response in Escherichia coli and many other organisms is regulated by the nucleotides ppGpp and pppGpp. We show here for the first time that at least six staphylococcal species also synthesize ppGpp and pppGpp upon induction of the stringent response by mupirocin. Spots corresponding to ppGpp and pppGpp on thin-layer chromatograms suggest that pppGpp is the principal regulatory nucleotide synthesized by staphylococci in response to mupirocin, rather than ppGpp as in E. coli. 相似文献
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