共查询到20条相似文献，搜索用时 15 毫秒
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Doughty MB Aboudehen K Anderson G Li K Moore B Poolson T 《Nucleosides, nucleotides & nucleic acids》2004,23(11):1751-1765
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Z Debyser A M Vandamme R Pauwels M Baba J Desmyter E De Clercq 《The Journal of biological chemistry》1992,267(17):11769-11776
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Arranz ME Díaz JA Ingate ST Witvrouw M Pannecouque C Balzarini J De Clercq E Vega S 《Bioorganic & medicinal chemistry》1999,7(12):2811-2822
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N S Magnuson L E Perryman D M Decker J A Magnuson 《The International journal of biochemistry》1984,16(11):1163-1165
2'-Deoxyadenosine and 9-beta-D-arabinofuranosyladenine (ARA) are apparent suicide inhibitors for equine S-adenosylhomocysteine hydrolase. In initial velocity studies of the synthetic reaction converting adenosine and homocysteine to S-adenosylhomocysteine, adenine, adenosine 5'-triphosphate, and 9-beta-D-arabinofuranosyladenine were found to be competitive inhibitors with Kis of 3.8 microM, 1.1 mM, and 30 microM, respectively. In contrast, linear mixed inhibition was observed for 2'-deoxyadenosine, indicating that 2'-deoxyadenosine must bind in more than one fashion to the enzyme. 相似文献
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