共查询到20条相似文献,搜索用时 15 毫秒
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Saurabh Sahar Satoru Masubuchi Kristin Eckel-Mahan Simone Vollmer Luisa Galla Nicholas Ceglia Selma Masri Teresa K. Barth Benedetto Grimaldi Opeyemi Oluyemi Giuseppe Astarita William C. Hallows Daniele Piomelli Axel Imhof Pierre Baldi John M. Denu Paolo Sassone-Corsi 《The Journal of biological chemistry》2014,289(9):6091-6097
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Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma 总被引:3,自引:0,他引:3
Sibold S Roh V Keogh A Studer P Tiffon C Angst E Vorburger SA Weimann R Candinas D Stroka D 《FEBS letters》2007,581(5):989-994
NDRG1 is a hypoxia-inducible protein, whose modulated expression is associated with the progression of human cancers. Here, we reveal that NDRG1 is markedly upregulated in the cytoplasm and on the membrane in human hepatocellular carcinoma (HCC). We demonstrate further that hypoxic stress increases the cytoplasmic expression of NDRG1 in vitro, but does not result in its localization on the plasma membrane. However, grown within an HCC-xenograft in vivo, cells express NDRG1 in the cytoplasm and on the plasma membrane. In conclusion, hypoxia is a potent inducer of NDRG1 in HCCs, albeit requiring additional stimuli within the tumour microenvironment for its recruitment to the membrane. 相似文献
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Ethel R. Pereira Karen Frudd Walid Awad Linda M. Hendershot 《The Journal of biological chemistry》2014,289(6):3352-3364
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Kavita Purnanda Bhat Agnieszka Dorota Truax Susanna Fletcher Greer 《The Journal of biological chemistry》2010,285(34):25893-25903
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