共查询到20条相似文献,搜索用时 15 毫秒
1.
Simone Wörtge Leonid Eshkind Nina Cabezas-Wallscheid Bernard Lakaye Jinhyun Kim Rosario Heck Yasmin Abassi Mustafa Diken Rolf Sprengel Ernesto Bockamp 《BMC developmental biology》2010,10(1):95
Background
Conditional gene activation is an efficient strategy for studying gene function in genetically modified animals. Among the presently available gene switches, the tetracycline-regulated system has attracted considerable interest because of its unique potential for reversible and adjustable gene regulation. 相似文献2.
Ting Gong Jianhua Xuan Li Chen Rebecca B Riggins Huai Li Eric P Hoffman Robert Clarke Yue Wang 《BMC bioinformatics》2011,12(1):82
Background
Genes work coordinately as gene modules or gene networks. Various computational approaches have been proposed to find gene modules based on gene expression data; for example, gene clustering is a popular method for grouping genes with similar gene expression patterns. However, traditional gene clustering often yields unsatisfactory results for regulatory module identification because the resulting gene clusters are co-expressed but not necessarily co-regulated. 相似文献3.
Andreas Schlicker Francisco S Domingues Jörg Rahnenführer Thomas Lengauer 《BMC bioinformatics》2006,7(1):302-16
Background
Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods that compare gene products regarding their molecular function and biological role. 相似文献4.
Background
Ceratopteris richardii is a useful experimental system for studying gametophyte development and sexual reproduction in plants. However, few tools for cloning mutant genes or disrupting gene function exist for this species. The feasibility of systemic gene silencing as a reverse genetics tool was examined in this study. 相似文献5.
Christoph Kaleta Anna Göhler Stefan Schuster Knut Jahreis Reinhard Guthke Swetlana Nikolajewa 《BMC systems biology》2010,4(1):116
Background
Although Escherichia coli is one of the best studied model organisms, a comprehensive understanding of its gene regulation is not yet achieved. There exist many approaches to reconstruct regulatory interaction networks from gene expression experiments. Mutual information based approaches are most useful for large-scale network inference. 相似文献6.
7.
Marjan De Mey Jo Maertens Gaspard J Lequeux Wim K Soetaert Erick J Vandamme 《BMC biotechnology》2007,7(1):34
Background
Nowadays, the focus in metabolic engineering research is shifting from massive overexpression and inactivation of genes towards the model-based fine tuning of gene expression. In this context, the construction of a library of synthetic promoters of Escherichia coli as a useful tool for fine tuning gene expression is discussed here. 相似文献8.
Background
Connectivity mapping is a process to recognize novel pharmacological and toxicological properties in small molecules by comparing their gene expression signatures with others in a database. A simple and robust method for connectivity mapping with increased specificity and sensitivity was recently developed, and its utility demonstrated using experimentally derived gene signatures. 相似文献9.
Background
Survival time is an important clinical trait for many disease studies. Previous works have shown certain relationship between patients' gene expression profiles and survival time. However, due to the censoring effects of survival time and the high dimensionality of gene expression data, effective and unbiased selection of a gene expression signature to predict survival probabilities requires further study. 相似文献10.
Phylogenetic reconstruction of ancestral character states for gene expression and mRNA splicing data
Background
As genomes evolve after speciation, gene content, coding sequence, gene expression, and splicing all diverge with time from ancestors with close relatives. A minimum evolution general method for continuous character analysis in a phylogenetic perspective is presented that allows for reconstruction of ancestral character states and for measuring along branch evolution. 相似文献11.
Yan Dong Aliona Bogdanova Bianca Habermann Wolfgang Zachariae Julie Ahringer 《BMC developmental biology》2007,7(1):19
Background
RNA interference coupled with videorecording of C. elegans embryos is a powerful method for identifying genes involved in cell division processes. Here we present a functional analysis of the gene B0511.9, previously identified as a candidate cell polarity gene in an RNAi videorecording screen of chromosome I embryonic lethal genes. 相似文献12.
Background
Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falciparum gene, MB2, were shown previously to have a stage-specific pattern of subcellular localization and proteolytic processing. 相似文献13.
Background
Microarray data discretization is a basic preprocess for many algorithms of gene regulatory network inference. Some common discretization methods in informatics are used to discretize microarray data. Selection of the discretization method is often arbitrary and no systematic comparison of different discretization has been conducted, in the context of gene regulatory network inference from time series gene expression data. 相似文献14.
Changhui Yan Michael Terribilini Feihong Wu Robert L Jernigan Drena Dobbs Vasant Honavar 《BMC bioinformatics》2006,7(1):262
Background
Understanding the molecular details of protein-DNA interactions is critical for deciphering the mechanisms of gene regulation. We present a machine learning approach for the identification of amino acid residues involved in protein-DNA interactions. 相似文献15.
Background
The number of sequenced eukaryotic genomes is rapidly increasing. This means that over time it will be hard to keep supplying customised gene finders for each genome. This calls for procedures to automatically generate species-specific gene finders and to re-train them as the quantity and quality of reliable gene annotation grows. 相似文献16.
Background
Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene functional annotations is a limiting factor. In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN) analyses. 相似文献17.
Stéphanie Jaubert-Possamai Gaël Le Trionnaire Joël Bonhomme Georges K Christophides Claude Rispe Denis Tagu 《BMC biotechnology》2007,7(1):63
Background
RNA interference (RNAi) is a powerful method to inhibit gene expression in a sequence specific manner. 相似文献18.
Background
With the biomedical literature continually expanding, searching PubMed for information about specific genes becomes increasingly difficult. Not only can thousands of results be returned, but gene name ambiguity leads to many irrelevant hits. As a result, it is difficult for life scientists and gene curators to rapidly get an overall picture about a specific gene from documents that mention its names and synonyms. 相似文献19.