共查询到20条相似文献,搜索用时 15 毫秒
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Slagsvold T Kraus I Bentzen T Palvimo J Saatcioglu F 《Molecular endocrinology (Baltimore, Md.)》2000,14(10):1603-1617
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Zhou D Quach KM Yang C Lee SY Pohajdak B Chen S 《Molecular endocrinology (Baltimore, Md.)》2000,14(7):986-998
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Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells 总被引:6,自引:0,他引:6
The androgen receptor (AR) can be activated in the absence of androgens by interleukin-6 (IL-6) in human prostate cancer cells. The events involved in ligand-independent activation of the AR are unknown, but have been suggested to involve phosphorylation of the AR itself or a receptor-associated protein. Steroid receptor coactivator-1 (SRC-1) has been shown to interact with the human AR and to modulate ligand-dependent AR transactivation and is regulated by phosphorylation by MAPK. To date, no one has examined the role of SRC-1 in ligand-independent activation of the AR by IL-6 or other signaling pathways known to activate the full-length receptor. This study addressed this and has revealed the following. 1) SRC-1 similarly enhanced ligand-independent activation of the AR by IL-6 to the same magnitude as that obtained via ligand-dependent activation. 2) Androgen and IL-6 stimulated the MAPK pathway. 3) MAPK was required for both ligand-dependent and ligand-independent activation of the AR. 4) Phosphorylation of SRC-1 by MAPK was required for optimal ligand-independent activation of the AR by IL-6. 5) Protein-protein interaction between endogenous AR and SRC-1 was dependent upon treatment of LNCaP cells with IL-6 or R1881. 6) Protein-protein interaction between the AR N-terminal domain and SRC-1 was independent of MAPK. 7) Ligand-independent activation of the AR did not occur by a mechanism of overexpression of either solely wild-type SRC-1 or mutant SRC-1 that mimics its phosphorylated form. 相似文献
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Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.
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Frances M. Sladek Michael D. Ruse Jr. Luviminda Nepomuceno Shih-Ming Huang Michael R. Stallcup 《Molecular and cellular biology》1999,19(10):6509-6522
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Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha 总被引:1,自引:0,他引:1
Qi C Chang J Zhu Y Yeldandi AV Rao SM Zhu YJ 《The Journal of biological chemistry》2002,277(32):28624-28630
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Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4 总被引:5,自引:0,他引:5
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Chou WC Prokova V Shiraishi K Valcourt U Moustakas A Hadzopoulou-Cladaras M Zannis VI Kardassis D 《Molecular biology of the cell》2003,14(3):1279-1294