LEEP刀联合纳米银抗菌水凝胶治疗重度宫颈糜烂疗效观察

目的探讨LEEP刀联合纳米银抗菌水凝胶治疗重度宫颈糜烂的临床效果。方法将128例重度宫颈糜烂患者随机分为观察组66例和对照组62例,两组均行LEEP切除术,术后观察组给予纳米银抗菌水凝胶治疗。结果两组有效率均达100%,但观察组的治愈率(95.45%)明显优于对照组(83.87%),差异有统计学意义(P0.05);术后创面恢复时间、阴道流液量和出血量、术后并发症发生率比较,差异具有统计学意义(P0.01,P0.05)。结论 LEEP联合纳米银抗菌水凝胶治疗重度宫颈糜烂疗效确切,阴道流液量、出血量及并发症少,值得推广。     

米非司酮联合桂枝茯苓胶囊治疗子宫肌瘤疗效观察

目的:探讨米非司酮联合桂枝茯苓胶囊应用于子宫肌瘤治疗的可行性及安全性。方法:76例子宫肌瘤患者随机分为两组,对照组予以米非司酮单独治疗,治疗组加入桂枝茯苓胶囊联合治疗,完成治疗后观察疗效。结果:治疗组总有效率(84.2%)显著高于对照组总有效率(71.1%),组间差异有统计学意义(P<0.05);通过降低患者血生殖激素水平及改变血液流变学情况,两种治疗方法最终有效缩小子宫肌瘤体积,显著改善患者月经量增多、经期延长和贫血症状,且治疗组疗效优于对照组(P<0.05)。结论:米非司酮联合桂枝茯苓胶囊可协同治疗子宫肌瘤,效果较好,且安全性较高。     

米非司酮联合桂枝茯苓胶囊治疗子宫肌瘤疗效观察

目的：探讨米非司酮联合桂枝茯苓胶囊应用于子宫肌瘤治疗的可行性及安全性。方法：76例子宫肌瘤患者随机分为两组,对照组予以米非司酮单独治疗,治疗组加入桂枝茯苓胶囊联合治疗,完成治疗后观察疗效。结果：治疗组总有效率（84．2％）显著高于对照组总有效率（71．1％）,组间差异有统计学意义（P〈0．05）;通过降低患者血生殖激素水平及改变血液流变学情况,两种治疗方法最终有效缩小子宫肌瘤体积,显著改善患者月经量增多、经期延长和贫血症状,且治疗组疗效优于对照组（P〈0．05）。结论：米非司酮联合桂枝茯苓胶囊可协同治疗子宫肌瘤,效果较好,且安全性较高。     

桂枝茯苓胶囊治疗盆腔炎性后遗症的临床疗效及对TGF-β1、IL-4水平的影响

目的探讨桂枝茯苓胶囊治疗盆腔炎性后遗症的临床疗效及对TGF-β1、IL-4水平的影响。方法选取116例盆腔炎性后遗症患者,按照随机数字表法分为对照组(58例)和观察组(58例),对照组常规使用妇科千金胶囊进行治疗,观察组在对照组治疗方案的基础上加用桂枝茯苓胶囊进行治疗,两组患者均连续治疗3个疗程。考察两组患者的临床疗效、WHOQOL-BREF评分、血清中TGF-β1和IL-4水平及不良反应等。结果经治疗后,观察组临床总有效率94.8%与对照组临床总有效率75.9%比较,差异有统计学意义(χ~2=4.1699,P0.05);两组患者的健康状况、生存质量、自我感觉及日常生活的WHOQOL-BREF评分与治疗前比较,差异均有统计学意义(Ps0.05),但观察组各指标的改善程度显著较对照组好,经统计学分析差异均有统计学意义(Ps0.05);两组患者血清中TGF-β1和IL-4水平与治疗前比较,差异均有统计学意义(Ps0.05),但观察组各指标的改善程度显著较对照组好,经统计学分析表明差异均有统计学意义(Ps0.05);对照组不良反应发生率15.5%与观察组不良反应发生率12.1%比较,差异无统计学意义(χ~2=0.1450,P0.05)。结论采用桂枝茯苓胶囊治疗盆腔炎性后遗症,可显著改善临床症状,提高患者的生活质量及临床疗效,且安全性较好,具有较大的临床借鉴意义。     

桂枝茯苓丸联合米非司酮对子宫肌瘤患者血液流变学及血红蛋白、人附睾蛋白4的影响

目的:研究桂枝茯苓丸联合米非司酮对子宫肌瘤患者血液流变学及血红蛋白(Hb)、人附睾蛋白4(HE4)的影响。方法:选取2016年3月到2017年5月西安交通大学医学院附属三二〇一医院收治的172例子宫肌瘤患者,随机分为观察组(n=86)和对照组(n=86)。对照组给予米非司酮治疗,观察组在对照组的基础上联合桂枝茯苓丸治疗,对比两组疗效,比较两组治疗前及治疗后的Hb、HE4、肌瘤体积、血液流变学指标以及不良反应。结果:观察组的总有效率为97.67%,高于对照组的89.53%(P0.05);治疗后,两组的Hb水平均明显高于治疗前,且观察组高于对照组(P0.05),两组的HE4水平均低于治疗前,观察组低于对照组(P0.05),肌瘤体积均小于治疗前,且观察组小于对照组(P0.05);治疗后两组的全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)及血小板聚集率(PAR)均低于治疗前,且观察组低于对照组(P0.05);观察组、对照组不良反应的总发生率分别为13.95%、10.47%,差异无统计学意义(P0.05)。结论:桂枝茯苓丸联合米非司酮治疗子宫肌瘤患者的疗效较好,可改善其血液流变学及Hb、HE4等指标水平,安全性较好,值得推广。     

康妇消炎栓联合保妇康栓治疗宫颈炎疗效分析

目的探讨宫颈糜烂的有效治疗方法。方法选择轻中度宫颈糜烂伴有腰骶痛患者160例,随机分为治疗组和对照组各80例。对照组采用单纯保妇康栓治疗,治疗组采用康妇消炎栓联合保妇康栓治疗,并对两组疗效进行比较。结果对照组总有效率80%,治疗组总有效率95%,治疗组治愈率明显高于对照组。结论康妇消炎栓联合保妇康栓治疗宫颈糜烂疗效显著。     

妇科千金胶囊联合桂枝茯苓丸对卵巢囊肿患者血清性激素水平的影响及临床疗效

目的:探讨妇科千金胶囊联合桂枝茯苓丸对卵巢囊肿患者血清性激素水平的影响及临床疗效。方法:选择我院收治的卵巢囊肿患者260例,随机分为实验组与对照组,对照组患者给予妇科千金胶囊治疗,实验组患者在对照组基础上联合使用桂枝茯苓丸治疗。观察并比较治疗前后两组患者血清雌二醇(E2)、孕酮(P)、促黄体生成素(LH)、促卵泡刺激素(FSH)、一氧化氮(NO)及肿瘤坏死因子-α(TNF-α)水平的变化情况及其临床总有效率。结果:与治疗前相比,两组患者治疗后血清E2、P及NO水平均降低,而血清LH、FSH及TNF-α水平均升高,差异具有统计学意义(P0.05);与对照组相比,实验组患者治疗后血清E2、P、NO水平较低,而血清LH、FSH及TNF-α水平较高,差异具有统计学意义(P0.05);实验组临床总有效率(90.77%)高于对照组(80.77%),差异具有统计学意义(P0.05)。结论:妇科千金胶囊联合桂枝茯苓丸治疗卵巢囊肿的效果较好,推测其机制可能与降低E2、P、NO水平,升高LH、FSH及TNF-α水平有关。     

微波联合抗生素治疗盆腔炎疗效观察

目的观察微波联合抗生素治疗盆腔炎的临床疗效。方法采用抗生素加微波治疗,对照组采用抗生素进行治疗,比较两组临床疗效。结果观察组30例治愈27例,好转2例。治愈率90．0％．总有效率96．67％。对照组30患者治愈24例,好转3倒,治愈率80．0％。总有效率90．0％。两组差异有统计学意义。结论微波联合抗生素治疗盆腔炎性的治疗效果肯定,值得基层医疗机构推广应用。     

桂枝茯苓丸联合妇乐片对子宫内膜异位症的临床疗效

目的:探讨桂枝茯苓丸联合妇乐片对子宫内膜异位症患者血清甲胎蛋白(AFP)、血清脂质结合唾液酸(LSA)及临床疗效的影响。方法:选取我院确诊并治疗的子宫内膜异位症患者68例,按随机数字表法进行分组,每组34例。对照组患者予以妇乐片口服治疗;研究组患者在对照组用药基础上予以桂枝茯苓丸联合治疗,所有患者连续服药6个月。观察两组患者治疗前后血清甲胎蛋白(AFP)、血清LSA、肿瘤坏死因子-α(TNF-α)及血管内皮生长因子(VEGF)水平的变化情况、临床疗效及不良反应发生率。结果:研究组治疗后临床有效率91.18%,高于对照组治疗后临床有效率70.59%,差异具有统计学意义(P0.05);与对照组比较,研究组治疗后血清AFP、LSA、TNF-α、VEGF水平降低,差异具有统计学意义(P0.05);对照组不良反应发生率为8.24%,研究组不良反应发生率为5.88%,两组间不良反应发生率无统计学意义(P0.05)。结论:采用桂枝茯苓丸联合妇乐片治疗子宫内膜异位症,能有效提高患者的临床疗效,推测其机制与降低血清AFP、LSA、TNF-α、VEGF水平有关。     

金双歧联合思密达治疗肝源性腹泻33例

目的:研究金双歧联合思密达治疗肝源性腹泻的疗效。方法:将66例肝源性腹泻的病人分为两组,治疗组及对照组各33例。两组均给予适当休息、合理饮食,积极护肝及对症支持等综合治疗;在此基础上,治疗组使用金双歧(2．0g,每日三次)联合思密达(3．0g,每日三次)治疗;对照组口服左氧氟沙星(0．2g,每日两次)治疗。疗程均为7天～14天。疗效判断标准:①显效:腹泻消失,大便成形,每日一次;②有效:腹泻次数明显减少或大便基本成形;③无效:症状无改善或大便次数增多。以显效和有效计算总有效率。结果:治疗组显效13例,有效17例,总有效率90．9%;对照组显效10例,有效6例,总有效率48．5%。两组疗效对比差异有统计学意义(x2=15．45,P＜0．001)。结论:金双歧联合思密达治疗肝源性腹泻疗效显著,值得临床推广应用。     

Investigation of the mechanism of temperature sensitivity of the electroreceptors of ampullae of lorenzini

In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980.     

Principles of organization and evolution of systems of regulation of functions

Evolution of living organisms is closely connected with evolution of structure of the system of regulations and its mechanisms. The functional ground of regulations is chemical signalization. As early as in unicellular organisms there is a set of signal mechanisms providing their life activity and orientation in space and time. Subsequent evolution of ways of chemical signalization followed the way of development of delivery pathways of chemical signal and development of mechanisms of its regulation. The mechanism of chemical regulation of the signal interaction is discussed by the example of the specialized system of transduction of signal from neuron to neuron, of effect of hormone on the epithelial cell and modulation of this effect. These mechanisms are considered as the most important ways of the fine and precise adaptation of chemical signalization underlying functioning of physiological systems and organs of the living organism