Morphofunctional changes in the insular apparatus of the pancreas following hypophysectomy and administration of somatotropic hormone]

Mature white male rats were used to study effects of hypophysectomy and STH on sugar content after fasting and after reiterated glucose loading. Morphological and morphometrical investigation of the pancreatic endocrine tissue were made. Zinc content and distribution in the pancreas, as well as aldehydefuchsinophil granulation in B-cells of the islets of Langergans were studied. Hypophysectomy was stated to increase functional activity of the pancreatic insular apparatus. Injection of STH for 9 days resulted in the stimulation of the cells in the insular apparatus. Prolonged injection of STH (for 20 days) produced exhaustion of the pancreatic insular apparatus.