Aquilegifolin: a triterpenoid glycoside from Thalictrum aquilegifolium

A new triterpenoid glycoside, aquilegifolin, has been isolated from Thalictrum aquilegifolium and the structure established by chemical transformations, spectral analysis and comparison with closely related compounds.     

A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity

A new secoiridoid glycoside, isopatrinioside (1) and a new sesquiterpenoid glycoside, valeriananoid F (2), together with nine known compounds, were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was an unusual monocyclic iridoid glycoside ring-opened between C-1 and C-2 produced by the cleavage of the pyran ring. Of the eleven isolates, compounds 1 and 4 exhibited moderate neuroprotective effects against CoCl₂-induced neuronal cell death in PC12 cells.     

A new triterpenoid alcohol from Trema orientalis

Substances isolated from the stem-bark of Trema orientalis include a new pentacyclic triterpenoid alcohol, for which the name trematol is proposed. From its physical and chemical properties a partial structure is assigned, consisting of an arborane or a migrated hopane skeleton, with a 3β-hydroxyl group and minor modifications in rings D and E.     

Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.

A new lignan glycoside, 1-[3,6-(4,4⿲-dihydroxy-3,3⿲-dimethoxy-δ-truxinyl)-β-fructofuranosyl]-α-glucopyranoside (1), named coixlachryside A, together with nine known simple phenolic compounds (3⿿11) were isolated from the roots of Coix lachryma-jobi var. ma-yuen using various chromatographic methods. Their chemical structures were determined based on the spectroscopic data interpretation, particularly circular dichroism (CD), 1D and 2D NMR data including HSQC and HMBC.     

A new semiterpenoid glycoside and a new benzofuran derivative glycoside from the roots of Heracleum dissectum

A new semiterpenoid glycoside, 3-methylbutan-1, 3-diol-1-O-β-d-glucopyranoside (1) and a new benzofuran derivative glycoside, 6-carboxylethyl-benzofuran-5-O-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranoside (2), together with seven known compounds (3-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti-inflammatory activity in vitro. And the result showed that compound 2 exhibited significantly inhibitory activity on nitric oxide production in RAW264.7 cells, which IC₅₀ value was equivalent to that of the positive control indomethacin.     

Xanthoxylone: A new triterpenoid ketone from Xanthoxylum rhetsa

Xanthoxylone, a new pentacyclic triterpenoid ketone has been isolated from a rutaccous plant, Xanthoxylum rhetsa. From spectral properties and conversion experiments the structure and stereochemistry of the terpenoid have been deduced as 1.     

A novel neolignan glycoside from Aquilaria sinensis

Phytochemical investigation of Aquilaria sinensis afforded one novel neolignan glycoside (1) and fourteen known compounds (2–15). Their structures were elucidated by spectroscopic methods. Among them, compounds 1–3, 5 and 7–9 were obtained from the genus Aquilaria for the first time. The profile of chromone glycosides and iriflophenone glycosides may have chemotaxonomic significance within this genus.     

Pridentigenin E,a triterpenoid sapogenin from Primula denticulata

The triterpenoid sapogenin pridentigenin E, isolated from Primula denticulata, has been identified as dihydrocyclamiretin D.     

A new secoiridoid and a new xanthone glycoside from the whole plants of Lomatogonium rotatum

A new secoiridoid (1) and a new xanthone glycoside (2), together with fourteen known compounds (3−16) were isolated from the dried whole plants of Lomatogonium rotatum (L.) Fries ex Nym. The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. All the compounds were evaluated for anti-complementary activity against the alternative pathways. Compounds 12 and 16 exhibited anti-complementary activity.     

Two new penterpenoid saponins and a new diterpenoid glycoside from Hemsleya chinensis

Two new penterpenoid saponins, hemsloside-Ma4 (1) hemsloside-Ma5 (2), and a new diterpenoid glycoside, hemsloside-Ma6 (3), were isolated from the rhizomes of Hemsleya chinensis. By detailed analysis of the NMR spectra and chemical methods, the structures of new compounds were determined to be 3-O-β-l-arabinopyranosyl-(1 → 3)-O-(6′-methyl ester)-β-d-glucuropyranosyl-oleanolic acid-28-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranoside (1), 3-O-β-l-arabinopyranosyl-(1 → 3)-O-(6′-methyl ester)-β-d-glucuropyranosyl-oleanolic acid-28-O-β-d-xylopyranosyl-(1 → 6)-O-β-d-glucopy-ranoside (2), and 13ϵ-hydroxylabda-8(17), 14-dien-18-oic acid-18-O-α-l-rhamnopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)-O-α-l-rhamnopyranoside (3). Diterpenoid-type compound (3) was isolated from Hemsleya genus for the first time.     

Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum

The structure and antioxidant properties of a new natural glycoside, trichotomoside (1), isolated from Clerodendron trichotomum, were investigated. Trichotomoside was identified as 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(2,3-di-O-acetyl-alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH-radical-scavenging effects. The radical-scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79-4 cells) exposed to H2O2 and gamma-irradiation.     

Esters of new oleanane-type triterpenoid saponins from Schefflera kwangsiensis

Eleven new oleanane-type triterpenoid saponins were isolated from the aerial parts of Schefflera kwangsiensis (1–11), together with nine esters (12–20) of known saponins. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 2, 3, 5, 7, 8, 11–13, 15, 17 and 18 (10 μM) exhibited moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.     

A new flavonoid glycoside from the leaves of Homonoia riparia

One new flavonol glycoside, myricetin 3-O-(6″-3,4-dihydroxybenzoyl)-β-glucopyranoside (1) and 13 known compounds (2 − 14) were isolated from the leaves of Homonoia riparia. Their structures were elucidated by spectroscopic methods. Among them, compounds 1–12 were obtained from the genus Homonoia for the first time. Compounds 4, 5, 8 and 11 were isolated for the first time in Euphorbiaceae family from present investigation.     

Anti-inflammatory activity of a new triterpenoid saponin from carthamus tinctorius linn

A new bioactive triterpenoid saponin 3β-O-[β-D-xylopyranosyl(1 → 3)-O-β-D-galactopyranosyl]-lup-12-ene-28 oic acid-28-O-α-L-rhamnopyranosyl ester compound (A), was isolated from the methanolic fraction of the roots of this plant by various colour reactions, chemical degradations and spectral analysis. Compound (A) showed anti-inflammatory activity.     

A flavanone glycoside from seeds of Sapium sebiferum

The isolation and identification of a new glycoside, eriodictyol 5-O-methyl ether 7-O-β-D-xylopyranosyl-β-D-arabinopyranoside, from seeds of Sapium sebiferum is reported.     

A new flavone glycoside from the leaves of Agastache rugosa (Fisch. & C.A.Mey.) Kuntze

Agastache rugosa (Fisch. & C.A.Mey.) Kuntze has been widely used as a food spice and a remedy for colds in Korea, China and Japan. In this study, one new flavone glycoside (1) along with six flavonoids (2–7), nine phenyl glycosides (8–16) and three megastigmane glycosides (17–19) were isolated from the leaves of A. rugosa. By extensive spectroscopic methods including 1D and 2D NMR, and MS data, the structure of the new compound (1) was elucidated as acacetin 7-O-β-(6″-(E)-crotonylglucopyranoside). From present investigation, compound 1 and 7–19 were isolated for the first time from the genus Agastache and 1, 16, 18 and 19 in the Lamiaceae family.