共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
Korn EL 《Biometrics》2012,68(1):239-41; discussion 245-7
6.
S. K. Jain 《Economic botany》2000,54(2):136-137
7.
8.
9.
10.
11.
E. B. Hazleton 《BMJ (Clinical research ed.)》1921,2(3171):578-579
12.
13.
14.
15.
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. 总被引:22,自引:0,他引:22
Sara C Kozma George Thomas 《BioEssays : news and reviews in molecular, cellular and developmental biology》2002,24(1):65-71
It has generally been observed that cells grow to a certain size before they divide. In the last few years, the PI3K signal transduction pathway has emerged as one of the main signaling routes utilized by cells to control their increase in size. Here we focus on two components of this pathway, PKB and S6K, and briefly review the experiments that initially uncovered their roles in cell size control. In addition, we discuss a number of recent observations suggesting that the generic models used to describe this pathway to date may have been oversimplified. Indeed, recent observations in Drosophila and mouse support a more complex interaction between these signaling components in development. Finally, we have utilized two contemporary studies involving PKB- and S6K-deficient mice as a paradigm to underscore the importance of cell size and to accurately delineate the connections between signaling pathways for human disease, such as diabetes mellitus. 相似文献
16.
17.
18.
19.
20.