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A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo 总被引:11,自引:0,他引:11
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Tsai EY Falvo JV Tsytsykova AV Barczak AK Reimold AM Glimcher LH Fenton MJ Gordon DC Dunn IF Goldfeld AE 《Molecular and cellular biology》2000,20(16):6084-6094
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Kominato Y Ueki M Iida R Kawai Y Nakajima T Makita C Itoi M Tajima Y Kishi K Yasuda T 《The FEBS journal》2006,273(13):3094-3105
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The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo 总被引:2,自引:0,他引:2
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Many pre-mRNAs are alternatively spliced in a tissue-specific manner in multicellular organisms. The Fox-1 family of RNA-binding proteins regulate alternative splicing by either activating or repressing exon inclusion through specific binding to UGCAUG stretches. However, the precise cellular contexts that determine the action of the Fox-1 family in vivo remain to be elucidated. We have recently demonstrated that ASD-1 and FOX-1, members of the Fox-1 family in Caenorhabditis elegans, regulate tissue-specific alternative splicing of the fibroblast growth factor receptor gene, egl-15, which eventually determines the ligand specificity of the receptor in vivo. Here we report that another RNA-binding protein, SUP-12, coregulates the egl-15 alternative splicing. By screening for mutants defective in the muscle-specific expression of our alternative splicing reporter, we identified the muscle-specific RNA-binding protein SUP-12. We identified juxtaposed conserved stretches as the cis elements responsible for the regulation. The Fox-1 family and the SUP-12 proteins form a stable complex with egl-15 RNA, depending on the cis elements. Furthermore, the asd-1; sup-12 double mutant is defective in sex myoblast migration, phenocopying the isoform-specific egl-15(5A) mutant. These results establish an in vivo model that coordination of the two families of RNA-binding proteins regulates tissue-specific alternative splicing of a specific target gene. 相似文献
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