共查询到20条相似文献,搜索用时 31 毫秒
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Violaine Moreau Cécile Fleury Dominique Piquer Christophe Nguyen Nicolas Novali Sylvie Villard Daniel Laune Claude Granier Franck Molina 《BMC bioinformatics》2008,9(1):71
Background
Most methods available to predict protein epitopes are sequence based. There is a need for methods using 3D information for prediction of discontinuous epitopes and derived immunogenic peptides. 相似文献2.
Background
Possible methods for distinguishing receptor binding models and analysing their parameters are considered. 相似文献3.
Background
Meta-analysis methods exist for combining multiple microarray datasets. However, there are a wide range of issues associated with microarray meta-analysis and a limited ability to compare the performance of different meta-analysis methods. 相似文献4.
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Background
Current protein clustering methods rely on either sequence or functional similarities between proteins, thereby limiting inferences to one of these areas. 相似文献6.
Background
Several methods are currently available for the comparison of protein structures. These methods have been analysed regarding the performance in the identification of structurally/evolutionary related proteins, but so far there has been less focus on the objective comparison between the alignments produced by different methods. 相似文献7.
Background
Molecular phylogenetic methods are based on alignments of nucleic or peptidic sequences. The tremendous increase in molecular data permits phylogenetic analyses of very long sequences and of many species, but also requires methods to help manage large datasets. 相似文献8.
Background
With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces. Therefore, methods that are able to identify whether these binding sites interact are needed. 相似文献9.
Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset
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Sung E Choe Michael Boutros Alan M Michelson George M Church Marc S Halfon 《Genome biology》2004,6(2):R16
Background
As more methods are developed to analyze RNA-profiling data, assessing their performance using control datasets becomes increasingly important. 相似文献10.
Marcin Olszewski Anna Grot Marek Wojciechowski Marta Nowak Małgorzata Mickiewicz Józef Kur 《BMC microbiology》2010,10(1):260
Background
In recent years, there has been an increasing interest in SSBs because they find numerous applications in diverse molecular biology and analytical methods. 相似文献11.
Background
Application of phenetic methods to gene expression analysis proved to be a successful approach. Visualizing the results in a 3-dimentional space may further enhance these techniques. 相似文献12.
Florent Baty Daniel Jaeger Frank Preiswerk Martin M Schumacher Martin H Brutsche 《BMC bioinformatics》2008,9(1):289
Background
Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages compared to common gene-by-gene approaches. However, due to their exploratory nature, multivariate ordination methods do not allow direct statistical testing of the stability of genes. 相似文献13.
Background
Concomitant with the rise in the popularity of DNA microarrays has been a surge of proposed methods for the analysis of microarray data. Fully controlled "spike-in" datasets are an invaluable but rare tool for assessing the performance of various methods. 相似文献14.
Background
Over the last decade several prediction methods have been developed for determining the structural and functional properties of individual protein residues using sequence and sequence-derived information. Most of these methods are based on support vector machines as they provide accurate and generalizable prediction models. 相似文献15.
Il-Han Kim Jens Nagel Simone Otten Boris Knerr Roland Eils Karl Rohr Steffen Dietzel 《BMC biotechnology》2007,7(1):92
Background
GFP-fusion proteins and immunostaining are methods broadly applied to investigate the three-dimensional organization of cells and cell nuclei, the latter often studied in addition by fluorescence in situ hybridization (FISH). Direct comparisons of these detection methods are scarce, however. 相似文献16.
Xu-Fang Yang Xu He Jian He Li-Hong Zhang Xue-Jin Su Zhi-Yong Dong Yun-Jian Xu Yan Li Yu-Lin Li 《Journal of biomedical science》2011,18(1):59
Background
Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering. 相似文献17.
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Background
Several in silico methods exist that were developed to predict protein interactions from the copious amount of genomic and proteomic data. One of these methods is Domain Fusion, which has proven to be effective in predicting functional links between proteins. 相似文献19.
Anne-Marie Boulay Christian Bouchard Cecile Bulle Louise Deschênes Manuele Margni 《The International Journal of Life Cycle Assessment》2011,16(7):639-651
Purpose
As impact assessment methods for water use in LCA evolve, so must inventory methods. Water categories that consider water quality must be defined within life cycle inventory. The method presented here aims to establish water categories by source, quality parameter and user. 相似文献20.
T.L. Buhr A.A. Young Z.A. Minter C.M. Wells D.C. McPherson C.L. Hooban C.A. Johnson E.J. Prokop J.R. Crigler 《Journal of applied microbiology》2012,113(5):1037-1051