共查询到20条相似文献,搜索用时 31 毫秒
1.
Weizhi Liu Kyle M. Draheim Rong Zhang David A. Calderwood Titus J. Boggon 《Molecular cell》2013,49(4):719-729
Highlights? Cocrystal structure of KRIT1 with ICAP1 shows a bidentate interaction interface ? Cocrystal structure of ICAP1 with integrin β1 shows a PTB-peptide interaction ? KRIT1 antagonizes ICAP1-modulated integrin activation by the bidentate interaction ? KRIT1 contains a previously undescribed N-terminal Nudix domain 相似文献
2.
Stelter M Gutsche I Kapp U Bazin A Bajic G Goret G Jamin M Timmins J Terradot L 《Structure (London, England : 1993)》2012,20(3):554-564
Highlights? Crystal structure of the ATPase domain of DnaB from Helicobacter pylori ? MALLS analysis shows that HpDnaB forms dodecamers ? EM reconstruction shows that HpDnaB forms head-to-head double hexamers 相似文献
3.
Sabri B. Erdemli Radhika Gupta William R. Bishai Gyanu Lamichhane L. Mario Amzel Mario A. Bianchet 《Structure (London, England : 1993)》2012,20(12):2103-2115
Highlights? The structure of Mtb LdtMt2 shows the binding of a peptidoglycan fragment ? The structure of the complex maps the interaction between acyl donor and enzyme ? Ldts show a conserved C-terminal ykuD domain with a divergent N-terminal domain ? Based on the structure of this complex, a reaction mechanism is proposed 相似文献
4.
Fairman JW Dautin N Wojtowicz D Liu W Noinaj N Barnard TJ Udho E Przytycka TM Cherezov V Buchanan SK 《Structure (London, England : 1993)》2012,20(7):1233-1243
Highlights? First intimin or invasin β domain structure—both crystallize as monomers ? First structure solved using 3-λ SeMet MAD data from crystals grown in LCP ? Identification of a non-BIG domain directly downstream of the β domain ? Highly conserved and coevolving residues are identified in the Int/Inv family 相似文献
5.
Highlights? Bacteriophytochrome structure containing photosensory and output transducing domain ? RpBphP1 binds to the cognate repressor RpPpsR2 on illumination with far-red light ? HOS domain is distantly related to Dhp and is essential for binding to the repressor ? Light-induced protomer swapping mechanism between dimers 相似文献
6.
Xu Liu Tyson R. Shepherd Ann M. Murray Zhen Xu Ernesto J. Fuentes 《Structure (London, England : 1993)》2013,21(3):342-354
Highlights? The Tiam1 PDZ domain preferentially binds a subset of syndecan (SDC) proteins ? The PDZ domain/phospho-SDC1 structure reveals a phosphoryl binding pocket ? Ligand specificity and phosphorylation regulate PDZ/SDC interactions and signaling ? Tiam1 PDZ domain dynamics are ligand-dependent and regulated by phosphorylation 相似文献
7.
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division 总被引:1,自引:0,他引:1
Highlights? A conserved protein, CdvA, recruits ESCRT-III to membranes during cell division ? Recruitment is mediated by a peptide-winged helix domain interaction ? We have determined the structure of this complex ? CdvA and a single ESCRT-III protein can drive membrane deformation in vitro 相似文献
8.
Quin MB Berrisford JM Newman JA Baslé A Lewis RJ Marles-Wright J 《Structure (London, England : 1993)》2012,20(2):350-363
Highlights? Regulation of cyclic di-GMP biosynthesis in Moorella thermoacetica ? Stressosome signal transduction and resetting ? X-ray crystal structure of type 2C phosphatase MtX ? X-ray crystal structures of phosphorylated MtS and the N-terminal domain of MtR 相似文献
9.
Marco Nardini Nerina Gnesutta Giacomo Donati Raffaella Gatta Claudia Forni Andrea Fossati Clemens Vonrhein Dino Moras Christophe Romier Martino Bolognesi Roberto Mantovani 《Cell》2013,152(1-2):132-143
Highlights? 3D structure of NF-Y/CCAAT shows close relationships to core histones H2A/H2B ? NF-YA displays a sequence-specific DNA minor groove-binding module ? Histone H2B and NF-YB share a functional posttranslational modification ? NF-Y binding and monoubiquitination are early events in gene activation 相似文献
10.
Highlights? Structures of the SAGA deubiquitinating module lacking the Sgf11 zinc finger domain ? The DUB module lacking the Sgf11 zinc finger forms a domain swapped complex dimer ? The conformational changes accompanying domain-swapping disrupt the active site ? Activating mutations in Ubp8 promote the compact form of the DUB module 相似文献
11.
Highlights? Myosin-IXA, an actin-motor- and RhoGAP-protein, is required for collective migration ? Myosin-IXA is required for radial actin bundle assembly at nascent cell-cell contacts ? The localization of myosin-IXA to actin bundles is dependent on its motor domain ? Myosin-IXA RhoGAP domain locally inhibits Rho stabilizing nascent cell-cell contacts 相似文献
12.
Highlights? The crystal structure of the DNA ligase IV/Artemis complex was solved at 2.4 Å ? The structure of DNA ligase IV (residues 1–609) shows inserts ? An Artemis helix forms a three-helix bundle with two helices from DNA ligase IV ? The structure provides insights into the mutations causing LIG4 syndrome 相似文献
13.
Cyril Hamiaux Revel S.M. Drummond Bart J. Janssen Susan E. Ledger Janine M. Cooney Richard D. Newcomb Kimberley C. Snowden 《Current biology : CB》2012,22(21):2032-2036
Highlights? DAD2 gene, identified by transposon tagging, encodes an α/β hydrolase fold protein ? DAD2 acts in the shoot; mutants are insensitive to strigolactones ? DAD2 crystal structure shows an internal cavity capable of binding strigolactones ? DAD2 can hydrolyze the strigolactone GR24 相似文献
14.
Highlights? Crystal structures of a central RyR domain contain phosphorylation sites ? Eleven RyR1 disease mutations cluster on two opposite faces of the domain ? The RyR1 L2867G mutation causes a drastic destabilization ? In vitro phosphorylation identifies 5 PKA and 4 CaMKII targets 相似文献
15.
Agromayor M Soler N Caballe A Kueck T Freund SM Allen MD Bycroft M Perisic O Ye Y McDonald B Scheel H Hofmann K Neil SJ Martin-Serrano J Williams RL 《Structure (London, England : 1993)》2012,20(3):414-428
Highlights? ESCRT-I subunit UBAP1 is essential for degradation of antiviral protein tetherin ? UBAP1 has a domain consisting of a solenoid of overlapping UBAs (SOUBA) ? Each of the three UBAs in the SOUBA binds monoubiquitin 相似文献
16.
Shan Liu Yinghua Chen Jess Li Tao Huang Sergey Tarasov Aaren King Allan M. Weissman R. Andrew Byrd Ranabir Das 《Structure (London, England : 1993)》2012,20(12):2138-2150
Highlights? The ubiquitin ligase gp78 recruits ubiquitinated substrates via its CUE domain ? gp78CUE:Ub complex reveals a large set of specific interactions ? gp78CUE binds to both distal and proximal moities of diubiquitin in a similar fashion ? The gp78CUE domain binds to K48- and K63-linked diubiquitin equally well 相似文献
17.
Arttu Jolma Jian Yan Thomas Whitington Jarkko Toivonen Kazuhiro R. Nitta Pasi Rastas Ekaterina Morgunova Martin Enge Mikko Taipale Gonghong Wei Kimmo Palin Juan M. Vaquerizas Renaud Vincentelli Nicholas M. Luscombe Timothy R. Hughes Patrick Lemaire Esko Ukkonen Teemu Kivioja Jussi Taipale 《Cell》2013,152(1-2):327-339
18.
Colin A. Smith Catherine A. Shi Matthew K. Chroust Thomas E. Bliska Mark J.S. Kelly Matthew P. Jacobson Tanja Kortemme 《Structure (London, England : 1993)》2013,21(1):54-64
Highlights? Successful design of phosphorylation sites into a globular protein ? Redesigned PDZ domain phosphorylation is associated with local destabilization ? Phosphorylation switches peptide binding function ? Phosphorylation switches peptide recognition specificity 相似文献
19.
Bénédicte F. Py Mi-Sung Kim Helin Vakifahmetoglu-Norberg Junying Yuan 《Molecular cell》2013,49(2):331-338
Highlights? Inhibition of deubiquitination blocks inflammasome activation ? Inhibition of deubiquitination induces NLRP3 polyubiquitination ? Deubiquitination of NLRP3 regulates the activation of inflammasome ? The deubiquitinating enzyme BRCC3 deubiquitinates the LRR domain of NLRP3 相似文献
20.
Roland Baumgartner Ingrid Poernbacher Nathalie Buser Ernst Hafen Hugo Stocker 《Developmental cell》2010,18(2):309-316
Highlights? The WW domain protein Kibra is a Hippo signalling component ? Kibra restricts organ size via Yorkie and acts upstream of Hippo and Merlin ? Kibra synergizes with Expanded and binds to Merlin 相似文献