World Picture, Anthropological Frame: DISTINGUISHED LECTURE—1976

This is the text of the seventh Distinguished Lecture of the American Anthropological Association, presented at its 75th Anniversary Meeting in Washington, D.C., November 1976. The Lectureship was established in 1969 to honor outstanding scholars in the profession and the lecture is now published each year in the American Anthropologist. Adams is an archaeologist and comparative anthropologist whose research interests have centered on the ecologically oriented study of prehistoric patterns of land use, settlement, and urbanization. His fieldwork has been in the Middle East, particularly in Iraq. He has served on the faculty of the University of Chicago since 1955, receiving his Ph.D. there in 1956. Besides appointments in the departments of Anthropology and Near Eastern Languages and Civilization, he has been Director of the Oriental Institute and Dean of the Division of Social Sciences at Chicago. He was Chairman of the Division of Behavioral Sciences of the National Research Council and is a member of the National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Adams' major publications include City Invincible (coeditor, 1960), Land Behind Baghdad (1965), The Evolution of Urban Society (1966, the Lewis Henry Morgan Lectures), and The Uruk Countryside (1972, with Hans J. Nissen).     

Direct physical formation of anatomical structures by cell traction forces. An interview with Albert Harris by Lev Beloussov

Albert Harris was educated at The Norfolk Academy, Norfolk, Virginia, USA (1961). He then earned a Batchelor of Arts Degree in Biology from Swarthmore College, in Pennsylvania, USA (1965), followed by a Ph.D. in Biology (1971) from Yale University, where his Dissertation Advisor was the great John Phillip Trinkaus. He held a Damon-Runyon Postdoctoral Fellowship in Cancer Research in 1970-72, under Michael Abercrombie, FRS, at the Strangeways Research Laboratory of Cambridge University, England. Then he accepted a position as Assistant Professor in the Zoology Department of the University of North Carolina at Chapel Hill, N.C. USA. In 1977, he was promoted to Associate Professor of Zoology, and in 1983 was promoted to Full Professor of Biology. In Oct.-Nov. 1991 he was honored to be Distinguished Visiting Professor of Zoology at the University of California at Davis.     

Potential of adenovirus as a vector for sustained gene expression

Inder Verma received his Ph.D. in biochemistry from the Weizmann Institute of Science, Rehovot, Israel, in 1971, and was a postdoctoral fellow (with David Baltimore) in the Department of Biology, Massachussetts Institute of Technology. He is currently American Cancer Society Professor of Molecular Biology, Chair of the Laboratory of Genetics at the Salk Institute for Biological Studies, and Adjunct Professor in the Department of Biology, University of California at San Diego. Inder Verma is a member of the National Academy of Sciences (USA). He is a member of the editorial boards of The Journal of Gene Medicine, Journal of Virology and Gene, and serves on several other scientific advisory boards. His major fields of interest are molecular analysis of oncoproteins, and suppressor genes, gene therapy involving retroviral, adenoviral, AAV vectors, and generation of novel lentiviral vectors. Copyright © 1999 John Wiley & Sons, Ltd.     

A conversation with Fernando Nottebohm, PhD. Interviewed by Michael Eisenstein

During the last 30 years, a number of revolutionary discoveries in the field of neuroscience have come from what was, at first, an unexpected direction: songbird research. Investigations into seasonal and sex-specific differences in birdsong development have led to important revelations about the impact of sex hormones on brain development and the hormonally controlled plasticity of brain structure, as well as the particularly surprising discovery that neurogenesis continues to occur in the adult brain (see Harding, p. 28). The work of Fernando Nottebohm is widely recognized as having played a key role in bringing these findings to light and thus forcing a general re-examination of established principles of neuroscience.Fernando Nottebohm is Dorothea L. Leonhardt Distinguished Professor at The Rockefeller University, and Director of The Rockefeller Field Research Center for Ethology and Ecology, a 1,200-acre facility located in Millbrook, NY, that provides researchers the opportunity to study behavior and brain function under natural conditions. Nottebohm's pioneering work on the neural control of birdsong has led to major discoveries with large impacts in the fields of animal behavior and neuroscience, and has made him one of the founders of neuroethology, the study of how the nervous system controls animal behavior.Nottebohm is a Member of the National Academy of Sciences, USA, and a Fellow of the American Association for the Advancement of Science and of the American Academy of Arts and Sciences. We had a chance to sit down with him to discuss his distinguished career working with laboratory birds.     

纪念戴芳澜教授诞辰九十周年

戴芳澜教授(1893.5.4—1973.1.3)是我国真菌学的创始人,也是我国植物病理学的主要奠基人之一。他为祖国培养了大量人才。为纪念他的光辉业绩,值戴教授诞辰九十周年、逝世十周年之际,特发表他的一篇评论性论文;戴教授的主要著作目录;俞大绂、陈鸿逵、周家炽、裘维蕃、相望年等教授的怀念性文章和他一生中各时期的照片两版,以资纪念。     

U.S. laws, regulations, and policies important to managers of nonhuman primate colonies

The various animal welfare laws, regulations, policies, accreditation standards, and welfare groups have an obvious impact on the activities of managers of nonhuman primate colonies. Federal organizations such as the Department of Health and Human Services, Department of Interior, the Department of Agriculture, the Department of Transportation, and the Justice Department regulate many aspects of animal management. Pertinent guidance is available through scientific organizations such as the American Association for Accreditation of Laboratory Animal Care and the National Academy of Sciences. Finally, the recommendations of responsible animal welfare organizations should also receive careful consideration.     

Q & A. [interview

Elaine and Gary Ostrander spent their youth in New Jersey and New York before heading to Nebraska for their teen years and eventually Washington State for High School and college, as their father moved around in library administration. Elaine was an undergraduate at the University of Washington, a graduate student at the Oregon Health Sciences University and a postdoc with James Wang at Harvard, studying DNA supercoiling. She next went to Berkeley, where she began the canine genome project, initiating the meiotic linkage map and working on human chromosome 21 at the Lawrence Berkeley National Labs. In 1993 she moved to the Fred Hutchinson Cancer Research Center where she is now a Member of the Divisions of Clinical Research and Human Biology. She is also an Affiliate Professor of Genome Sciences and Biology at the University of Washington, and heads the Program in Genetics at the Hutchinson Center. Gary completed his undergraduate degree in Biology at Seattle University, a M.S. degree at Illinois State University and a Ph.D at the University of Washington in Ocean and Fisheries Science. He went on to be a postdoc in the Department of Pathology at the University of Washington Medical School while being mentored by Senitroh Hakomori of the Fred Hutchinson Cancer Research Center and Eric Holmes of the Pacific Northwest Research Foundation. His work focused on using novel aspects of the biology of fishes to address fundamental questions about cancer. He subsequently held both faculty and administrative positions at Oklahoma State University. Since 1996, he has been at the Johns Hopkins University, where he currently holds academic appointments in the Departments of Biology and Comparative Medicine and is the Associate Provost for Research.     

Jorge Mardones: oration at his funeral service

Oratios at the funeral service of Prof Jorge Mardones, MD. A very successful and influential pharmacologist, he was Chairman of the Department of Pharmacology, Faculty of Medicine, University of Chile; President of the Academy of Sciences, Institute of Chile; National Prize of Sciences, 1977; and Minister of Public Health. He also served as Chief Editor of "Archivos de Biología y Medicina Experimentales" (former name of this journal) between 1964 and 1978.     

Recent Trends in the Management of Life-Threatening Ventricular Arrhythmias

An edited summary of an Interdepartmental Conference arranged by the Department of Medicine, UCLA School of Medicine, Los Angeles. William M. Pardridge, MD, Associate Professor of Medicine, is Director of Conferences.This study was supported in part by grants from the Public Health Service; the National Institutes of Health (HL-23970, 1978-1981); the Medical Research Service of the Veterans Administration, and the American Heart Association, the Greater Los Angeles Affiliate.     

Four Children and Yale: The Making of a Human Geneticist: The Grover Powers Lecture 2014

Dr. Leon E. Rosenberg delivered the following presentation as the Grover Powers Lecturer on May 14, 2014, which served as the focal point of his return to his “adult home” as a Visiting Professor in the Department of Pediatrics. Grover F. Powers, MD, was one of the most influential figures in American Pediatrics and certainly the leader who created the modern Department of Pediatrics at Yale when he was recruited in 1921 from Johns Hopkins and then served as its second chairman from 1927 to 1951. Dr. Powers was an astute clinician and compassionate physician and fostered and shaped the careers of countless professors, chairs, and outstanding pediatricians throughout the country. This lectureship has continued yearly since it first honored Dr. Powers in 1956. The selection of Dr. Rosenberg for this honor recognizes his seminal role at Yale and throughout the world in the fostering and cultivating of the field of human genetics. Dr. Rosenberg served as the inaugural Chief of a joint Division of Medical Genetics in the Departments of Pediatrics and Internal Medicine; he became Chair when this attained Departmental status. Then he served as Dean of the Medical School from 1984 to 1991, before he became President of the Pharmaceutical Research Institute at Bristol-Myers Squibb and later Senior Molecular Biologist and Professor at Princeton University, until his recent retirement. Dr. Rosenberg has received numerous honors that include the Borden Award from the American Academy of Pediatrics, the McKusick Leadership Award from the American Society for Human Genetics, and election to the Institute of Medicine and the National Academy of Sciences.     

Meeting report: Human fetal tissue transplantation research panel

Summary On September 14 through 16, 1988, a meeting on the use of human fetal tissue in transplantation was held at the National Institutes of Health, Bethesda Maryland, USA. The meeting sponsored by NIH for the Human Fetal Tissue Transplantation Research Panel, a consultant group to the Advisory Committee to the Director. The consultant group was convened to deal with the scientific, judicial and moral questions associated with research involving transplantation of human fetal tissue obtained after induced abortions. The first day of the meeting was devoted to presentations addressing scientific issues. Included among the speakers was Dr. Lars Olson, Professor of Neurobiology, Karolinska Institute, Stockholm, who described the use of transplanted human fetal tissue in the treatment of patients with Parkinkson's disease and Dr. Eugene Redmond, Professor of Psychiatry, Yale University School of Medicine, who showed results of work with transplantation of tissue to correct induced Parkinson-like disease in monkeys. Other speakers addressed the present, past or potential use of fetal tissue in the treatment of diabetes, immune disorders, and other diseases, as well as the use of fetal cells in the production of biologicals. At the conclusion of the meeting the panel did not recommend that research be halted on fetal tissue within the context discussed, although the recommendation of the committee is not binding, and an additional assembly of the panel will probably occur before the final recommendation to an NIH advisory committee is made in November. Other meetings on this subject include a meeting on the use of fetal tissue sponsored by the American Association of Tissue Banks, March 6–7, 1989, in Washington D. C. (Crystal City) and a meeting June 10, 1989, the day before the annual meeting of the Tissue Culture Association, USA, in Orlando, Florida, on fetal cells and ownership of cultured cells and products derived from clinical specimens. Following are statements to the Human Fetal Tissue Transplantation Research Panel presented September 14, 1988, by Dr. David Barnes, Associate Professor of Biochemistry and Biophysics in the Environmental Health Sciences Center at Oregon State University, USA, who was asked to address for the panel recent advances in cell culture related to fetal tissue, and Dr. Robert E. Stevenson, Director of the American Type Culture Collection, President of the Tissue Culture Association, USA, and Chairman of the Committee on Cells and Tumors of the American Association of Tissue Banks.     

Average Waiting Time of Clusterhead Controlled Token for Virtual Base Station On-Demand in MANETs

A wireless mobile Ad hoc network (MANET) is a collection of wireless mobile hosts forming nodes that are arbitrarily and randomly changing their locations and communicating without the aid of any centralized administration or standard support services. Ad hoc cluster-based routing protocols establish a dynamic wireless mobile infrastructure to mimic the operation of the fixed infrastructure in cellular networks. A clusterhead is elected from a set of nominees, based on an agreed upon rule, to act as a temporary base station within its zone or autonomous system. Mobile stations elected as clusterheads are used to track other mobile stations in the ad hoc network. In each cluster, we use the clusterhead controlled token to assign the channel among contending Mobile Terminals (MTs). A clusterhead controlled token supports multiple class of services and minimizes collisions. In this paper, we derive formulas to calculate the average waiting time for a packet, in order to get transmitted. In our study, we use two polling schemes, namely: Exhaustive polling and Partially Gated polling controlled token.Tarek Sheltami is currently an assistant professor at the Computer Engineering Department at King Fahd University of Petroleum and Minerals (KFUPM) Dhahran, Kingdom of Saudi Arabia. He joined the department on September, 2004. Before joining the KFUPM, Dr. Sheltami was a research associate professor at the School of Information Technology and Engineering (SITE), University of Ottawa, Ontario, Canada. He has two years of industrial experience at GamaEng Inc (2002–2004). He is the co-author of the Warning Energy Aware Clusterhead (WEAC) infrastructure protocol and the Virtual Base Station On-demand (VBS-O) routing protocol. Dr. Sheltami has been a member of a technical program and organizing committees of several international IEEE conferences. Dr. Sheltamis research interests are in the area of wireless communications, wireless ad hoc and sensors networks, mobile infrastructure protocols, network control/mobility management, UMTS, and performance evaluation of wireless communication networks.Hussein Mouftah joined the School of Information Technology and Engineering (SITE) of the University of Ottawa in September 2002 as a Canada Research Chair (Tier 1) Professor in Optical Networks. He has been with the Department of Electrical and Computer Engineering at Queens University (1979–2002), where he was prior to his departure a Full Professor and the Department Associate Head. He has three years of industrial experience mainly at Bell Northern Research of Ottawa, now Nortel Networks (1977–79). He has spent three sabbatical years also at Nortel Networks (1986–87, 1993–94, and 2000–01), always conducting research in the area of broadband packet switching networks, mobile wireless networks and quality of service over the optical Internet. He served as Editor-in-Chief of the IEEE Communications Magazine (1995–97) and IEEE Communications Society Director of Magazines (1998–99) and Chair of the Awards Committee (2002–2003). He is a Distinguished Speaker of the IEEE Communications Society since 2000. Dr. Mouftah is the author or coauthor of five books, 22 book chapters and more than 700 technical papers and 8 patents in this area. He is the recipient of the 1989 Engineering Medal for Research and Development of the Association of Professional Engineers of Ontario (PEO), and the Ontario Distinguished Researcher Award of the Ontario Innovation Trust. He is the joint holder of the Best Paper Award for a paper presented at SPECTS 2002, and the Outstanding Paper Award for papers presented at the IEEE HPSR 2002 and the IEEE ISMVLõ1985. Also he is the joint holder of a Honorable Mention for the Frederick W. Ellersick Price Paper Award for Best Paper in the IEEE Communications Magazine in 1993. He is the recipient of the IEEE Canada (Region 7) Outstanding Service Award (1995). Also he is the recipient of the 2004 IEEE Communications Society Edwin Howard Armstrong Achievement Award, and the 2004 George S. Glinski Award for Excellence in Research of the Faculty of Engineering, University of Ottawa. Dr. Mouftah is a Fellow of the IEEE (1990), the Canadian Academy of Engineering (2003) and the Engineering Institute of Canada (2005).     

The Formation and Function of the Children's Psychiatric Research Institute,London, Ont

The Children''s Psychiatric Research Institute was established in February 1960 by the Mental Health Branch of the Ontario Department of Health. Its formation was the result of co-operative efforts by the Ontario Association for Retarded Children, the University of Western Ontario and the senior members of the Mental Health Division of the Ontario Department of Health. It was established in London, Ontario, because of the interest in research in this area of medicine on the part of the University of Western Ontario Faculty of Medicine.Children suspected of being mentally retarded are accepted on referral by physicians or social agencies in southwestern Ontario. A multi-discipline team examines these patients for causal pathology, levels of function at intellectual, social and emotional parameters, and family relationships and reactions. In-patient facilities are available if required for additional investigation. The opportunity provided by the Institute and its patients for research and teaching is utilized through its close relationship with the University of Western Ontario. A postgraduate course in problems of mental retardation is offered to interested physicians.     

沙尘暴对北京市空气细菌多样性特征的影响

亚洲沙尘暴携带着各类污染物质,严重影响下风向地区大气过程及生态系统和相关人群的健康。然而,沙尘天气对中国华北地区空气细菌群落及多样性特征影响的研究较少。以北京市为例,系统研究了沙尘暴对城市空气细菌多样性特征的影响。2015年4月,通过定点采样连续收集了一次沙尘暴及其前后4天的空气颗粒物样本,DNA提取、PCR扩增后进行16S rRNA基因高通量测序。共获得169122条高质量序列,生物信息学分析表明,北京市空气细菌物种多样性较高,沙尘暴不能引起细菌OTU数目的增加,但沙尘暴天气下细菌群落Pielou、Shannon和Simpson指数显著增加。菌群分类分析发现,北京市空气细菌由35个细菌门构成,其中变形菌门(Proteobacteria)、放线菌门(Actinobacteria)、厚壁菌门(Firmicutes)和拟杆菌门(Bacteroidetes)相对丰度最高,分别占总序列的32.76%、28.09%、25.46%和6.32%;芽单胞菌门(Gemmatimonadetes)和酸杆菌门(Acidobacteria)次之,分别占序列总数的2.11%和1.81%,其他细菌门的相对丰度均低于1%。沙尘暴天气下,变形菌门(Proteobacteria)、拟杆菌门(Bacteroidetes)、芽单胞菌门(Gemmatimonadetes)和酸杆菌门(Acidobacteria)显著升高(P<0.05),分别由31.67%、5.74%、1.82%、1.51%升高至41.46%、10.98%、4.48%和4.26%;而放线菌门(Actinobacteria)、厚壁菌门(Firmicutes)显著降低(P <0.05),分别由28.84%、27.10%降低至22.13%和12.35%。冷杆菌属(Psychrobacter),纤维单胞菌属(Cellulomonas),不动杆菌属(Acinetobacter),假单胞菌属(Pseudomonas)和梭菌属(Clostridium)可能含有人类条件病原菌,其在沙尘暴天气中相对丰度下降,但绝对丰度会大幅增加。沙尘暴能降低人体免疫力,因此致病菌潜在健康风险可能显著增强。通过聚类分析和主成分分析发现,沙尘暴日与非沙尘暴日空气细菌群落差异较大,而沙尘暴前后群落结构差异较小。沙尘暴前后空气细菌群落α-多样性和β多样性均无显著差异,推测沙尘暴只能暂时影响空气细菌群落特征,不能显著改变其群落结构。本研究通过分析了沙尘暴侵袭下北京市空气细菌群落多样性特征及动态,为制定中国北方城市沙尘暴灾害预警措施和建立气传疾病的防控机制提供数据支持。     

The molecular genetics of bacteriophage: the work of Norton Zinder

In 1966, Norton Zinder and Joshua Lederberg discovered that Salmonella could exchange genes via bacteriophages. They named this phenomenon “genetic transduction.” This discovery set Zinder on a lifelong journey researching bacteriophage. In the two Journal of Biological Chemistry (JBC) Classic papers reprinted here, Zinder and Nina Fedoroff present their findings on the phage f2 replicase.Properties of the Phage f2 Replicase. I. Optimal Conditions for Replicase Activity and Analysis of the Polynucleotide Product Synthesized in Vitro (Fedoroff, N. V., and Zinder, N. D. (1972) J. Biol. Chem. 247, 4577–4585)Properties of the Phage f2 Replicase. II. Comparative Studies on the Ribonucleic Acid-dependent and Poly(C)-dependent Activities of the Replicase (Fedoroff, N. V., and Zinder, N. D. (1972) J. Biol. Chem. 247, 4586–4592)Norton David Zinder was born in New York City in 1928. He attended the prestigious Bronx High School of Science and went on to Columbia University where he received his B.A. in biology in 1947. Zinder then joined the graduate program at the University of Wisconsin-Madison, studying under geneticist Joshua Lederberg.Open in a separate windowNorton ZinderLederberg recently had found that Escherichia coli could mate and exchange genes (conjugation), a discovery for which he would be awarded the 1958 Nobel Prize in Physiology or Medicine. Zinder''s assignment was to continue Lederberg''s investigations using Salmonella. To do this, he needed to obtain large numbers of mutant bacteria. Rather than using the traditional method of exposing the Salmonella to mutagens and testing the survivors, Zinder decided to use a nutritionally deficient medium and penicillin (negative selection) to select for mutants (1). However, when he began investigating conjugation in Salmonella, most of his attempts at crossing the mutants failed. Fortunately, one mutant strain produced some prototrophs; but puzzlingly, Zinder''s markers did not segregate. Further experiments showed that the mutants were exchanging genes via bacteriophages (2). Lederberg and Zinder named this new phenomenon “genetic transduction.”Zinder received his M.S. in genetics in 1949 and completed his Ph.D. in medical microbiology in 1952. He then accepted a position as assistant professor at Rockefeller University (then known as Rockefeller Institute for Medical Research). By 1964 Zinder had become a full professor of genetics, and approximately 10 years later he was named John D. Rockefeller, Jr. Professor of Molecular Genetics. In 1993 Zinder was appointed dean of graduate and postgraduate studies.At Rockefeller, Zinder continued his studies of the molecular genetics of phages. He discovered the f2 phage, which was the first bacteriophage known to contain RNA as its genetic material, and demonstrated that RNA phage replication is not dependent on DNA (3).Zinder''s two Journal of Biological Chemistry (JBC) Classics reprinted here look at the phage f2 replicase. In the first paper, Zinder and his graduate student Nina V. Fedoroff show that the enzyme, purified on the basis of its poly(G) polymerase activity, could carry out the in vivo synthetic reactions involved in phage RNA replication. They also report that phage replicase activity is stimulated by salt and by a brief preliminary incubation at high ionic strength. The second paper, also by Zinder and Fedoroff and printed back-to-back with the first, compares the f2 poly(G) polymerase and replicase activities under a variety of conditions. They examined the effects of ionic strength, temperature, magnesium ion concentration, and template and substrate concentrations on the enzymes'' activities. Based on their results, Zinder and Fedoroff suggest a distinction between initiation and polymerization sites on the enzyme complex.Zinder remains at Rockefeller as John D. Rockefeller, Jr. Emeritus Professor and continues to research bacteriophage. Currently he is using genetics, biochemistry, and molecular biology to analyze the filamentous bacterial virus, f1, and its interactions with its host, Escherichia coli. His other studies relate to protein-DNA recognition, membrane anchoring, and questions of protein structure.In recognition of his many contributions to science, Zinder has received numerous honors and awards. These include the 1962 Eli Lilly Award in Microbiology and Immunology from the American Society of Microbiology, the 1966 Award in Molecular Biology from the National Academy of Sciences, the 1969 Medal of Excellence from Columbia University, and the 1982 Award for Scientific Freedom and Responsibility from the American Association for the Advancement of Science. Zinder became a member of the American Academy of Arts and Sciences in 1968 and of the National Academy of Sciences in 1969.Zinder''s coauthor on the two JBC papers also has gone on to a distinguished career in science. Fedoroff received her Ph.D. in 1972 and was a staff scientist at the Carnegie Institution of Washington. She joined the faculty of the Pennsylvania State University in 1995 and became the Evan Pugh Professor, Penn State''s highest academic honor, in 2002. She currently holds the Verne M. Willaman Chair of Life Sciences. In 2007, U. S. Secretary of State Condoleezza Rice named Fedoroff her science and technology adviser. She remains in this position today, serving U. S. Secretary of State Hillary Clinton. Fedoroff is a 2006 National Medal of Science laureate and a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the Phi Beta Kappa and Sigma Xi honor societies. Her current research focuses on the mechanisms that allow plants to withstand the environmental challenges of a changing climate.     

An Autonomic Reservoir Framework for the Stochastic Optimization of Well Placement

The adequate location of wells in oil and environmental applications has a significant economic impact on reservoir management. However, the determination of optimal well locations is both challenging and computationally expensive. The overall goal of this research is to use the emerging Grid infrastructure to realize an autonomic self-optimizing reservoir framework. In this paper, we present a policy-driven peer-to-peer Grid middleware substrate to enable the use of the Simultaneous Perturbation Stochastic Approximation (SPSA) optimization algorithm, coupled with the Integrated Parallel Accurate Reservoir Simulator (IPARS) and an economic model to find the optimal solution for the well placement problem. Wolfgang Bangerth is a postdoctoral research fellow at both the Institute for Computational Engineering and Sciences, and the Institute for Geophyics, at the University of Texas at Austin. He obtained his Ph.D. in applied mathematics from the University of Heidelberg, Germany in 2002. He is the project leader for the deal.II finite element library (http://www.dealii.org). Wolfgang is a member of SIAM, AAAS, and ACM. Hector Klie obtained his Ph.D. degree in Computational Science and Engineering at Rice University, 1996, he completed his Master and undergraduate degrees in Computer Science at the Simon Bolivar University, Venezuela in 1991 and 1989, respectively. Hector Klie's main research interests are in the development of efficient parallel linear and nonlinear solvers and optimization algorithms for large-scale transport and flow of porous media problems. He currently holds the position of Associate Director and Senior Research Associate in the Center for Subsurface Modeling at the Institute of Computational Science and Engineering at The University of Texas at Austin. Dr. Klie is current member of SIAM, SPE and SEG. Vincent Matossian obtained a Masters in applied physics from the French Université Pierre et Marie Curie. Vincent is currently pursuing a Ph.D. degree in distributed systems at the Department of Electrical and Computer Engineering at Rutgers University under the guidance of Manish Parashar. His research interests include information discovery and ad-hoc communication paradigms in decentralized systems. Manish Parashar is Professor of Electrical and Computer Engineering at Rutgers University, where he also is director of the Applied Software Systems Laboratory. He received a BE degree in Electronics and Telecommunications from Bombay University, India and MS and Ph.D. degrees in Computer Engineering from Syracuse University. He has received the Rutgers Board of Trustees Award for Excellence in Research (2004–2005), NSF CAREER Award (1999) and the Enrico Fermi Scholarship from Argonne National Laboratory (1996). His research interests include autonomic computing, parallel & distributed computing (including peer-to-peer and Grid computing), scientific computing, software engineering. He is a senior member of IEEE, a member of the IEEE Computer Society Distinguished Visitor Program (2004–2007), and a member of ACM. Mary Fanett Wheeler obtained her Ph.D. at Rice University in 1971. Her primary research interest is in the numerical solutions of partial differential systems with applications to flow in porous media, geomechanics, surface flow, and parallel computation. Her numerical work includes formulation, analysis and implementation of finite-difference/finite-element discretization schemes for nonlinear, coupled PDE's as well as domain decomposition iterative solution methods. She has directed the Center for Subsurface Modeling, The University of Texas at Austin, since its creation in 1990. Dr. Wheeler is recepient of the Ernest and Virginia Cockrell Chair in Engineering and is Professor in the Department of Aerospace Engineering & Engineering Mechanics and in the Department of Petroleum & Geosystems Engineering of The University of Texas     

Bacterial rhodopsins: evolution of a mechanistic model for the ion pumps

Walther Stoeckenius received a MD degree at the University of Hamburg, Germany in 1950. After 18 months of clinical work as an intern, he began postdoctoral work on the development of pox viruses at the Institute for Tropical Medicine in Hamburg using mainly electron microscopy techniques. After two years he moved as Assistant Professor to the Department of Pathology at the University of Hamburg and became Docent for Pathology in 1958. In addition to teaching and routine pathology work, he continued to use electron microscopy to explore the fine structure of cells and developed an interpretation of the triple-layered appearance of membranes in electron micrographs in terms of molecular structure and the chemistry of osmium tetroxide fixation. In 1959 he obtained a position as Research Associate in Keith Porter's laboratory at Rockefeller University. This was changed after a few months to Assistant Professor and he stayed there, later as Associate Professor, for eight years. The work on membrane structure continued, and a model was developed that described the membrane as a lipid bilayer with embedded protein domains. In efforts to isolate such domains, the purple membrane and bacteriorhodopsin were discovered. In 1966, the lure of California became irresistible and Dr. Stoeckenius accepted a professorship at the University of California at San Francisco. The work on bacteriorhodopsin continued there with the emphasis changing from electron microscopy to spectroscopy and biochemical techniques. He is now Professor Emeritus there in the Department of Biochemistry and Biophysics and the Cardiovascular Research Institute.