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1.
Painful channels in sensory neurons   总被引:3,自引:0,他引:3  
Lee Y  Lee CH  Oh U 《Molecules and cells》2005,20(3):315-324
Pain is an unpleasant sensation experienced when tissues are damaged. Thus, pain sensation in some way protects body from imminent threat or injury. Peripheral sensory nerves innervated to peripheral tissues initially respond to multiple forms of noxious or strong stimuli, such as heat, mechanical and chemical stimuli. In response to these stimuli, electrical signals for conducting the nociceptive neural signals through axons are generated. These action potentials are then conveyed to specific areas in the spinal cord and in the brain. Sensory afferent fibers are heterogeneous in many aspects. For example, sensory nerves are classified as Aa, -b, -d and C-fibers according to their diameter and degree of myelination. It is widely accepted that small sensory fibers tend to respond to vigorous or noxious stimuli and related to nociception. Thus these fibers are specifically called nociceptors. Most of nociceptors respond to noxious mechanical stimuli and heat. In addition, these sensory fibers also respond to chemical stimuli [Davis et al. (1993)] such as capsaicin. Thus, nociceptors are considered polymodal. Recent advance in research on ion channels in sensory neurons reveals molecular mechanisms underlying how various types of stimuli can be transduced to neural signals transmitted to the brain for pain perception. In particular, electrophysiological studies on ion channels characterize biophysical properties of ion channels in sensory neurons. Furthermore, molecular biology leads to identification of genetic structures as well as molecular properties of ion channels in sensory neurons. These ion channels are expressed in axon terminals as well as in cell soma. When these channels are activated, inward currents or outward currents are generated, which will lead to depolarization or hyperpolarization of the membrane causing increased or decreased excitability of sensory neurons. In order to depolarize the membrane of nerve terminals, either inward currents should be generated or outward currents should be inhibited. So far, many cationic channels that are responsible for the excitation of sensory neurons are introduced recently. Activation of these channels in sensory neurons is evidently critical to the generation of nociceptive signals. The main channels responsible for inward membrane currents in nociceptors are voltage-activated sodium and calcium channels, while outward current is carried mainly by potassium ions. In addition, activation of non-selective cation channels is also responsible for the excitation of sensory neurons. Thus, excitability of neurons can be controlled by regulating expression or by modulating activity of these channels.  相似文献   

2.
近期的脑成像研究在盲人等感官缺陷被试者身上发现了感觉替换现象,即传统上认为仅对单一感觉通道刺激反应的皮层区域也参与其他感觉通道的信息加工.类似的效应在感觉剥夺(蒙住眼睛)的明视人被试中也被观察到,提示脑内可能预存着多感觉交互作用的神经通路.通常认为,上述神经通路在常态的人脑中是以潜伏形式存在的,只有当感觉剥夺时才显露出来或得到加强.但是,感觉剥夺是否是该类神经通路发挥作用的必要条件,已有的研究尚缺乏确切的证据.采用统计力度较强的实验设计,给未蒙眼明视人被试听觉呈现一组名词,要求其对听到的每一个词语做出是人工物体还是自然物体的语义判断.对同步采集的功能磁共振信号进行统计分析,观察到视皮层脑区有显著激活.这些结果表明,跨感觉通道的神经通路在未实施感觉剥夺的条件下依然能够显示出来,因而在常态人脑中也不是完全以潜伏形式存在的.上述研究为建立多感觉交互作用神经机制的具体理论模型提供了一个约束条件.  相似文献   

3.
Signal transduction through heterotrimeric G proteins is critical for sensory response across species. Regulator of G protein signaling (RGS) proteins are negative regulators of signal transduction. Herein we describe a role for C. elegans RGS-3 in the regulation of sensory behaviors. rgs-3 mutant animals fail to respond to intense sensory stimuli but respond normally to low concentrations of specific odorants. We find that loss of RGS-3 leads to aberrantly increased G protein-coupled calcium signaling but decreased synaptic output, ultimately leading to behavioral defects. Thus, rgs-3 responses are restored by decreasing G protein-coupled signal transduction, either genetically or by exogenous dopamine, by expressing a calcium-binding protein to buffer calcium levels in sensory neurons or by enhancing glutamatergic synaptic transmission from sensory neurons. Therefore, while RGS proteins generally act to downregulate signaling, loss of a specific RGS protein in sensory neurons can lead to defective responses to external stimuli.  相似文献   

4.
A hallmark of higher brain functions is the ability to contemplate the world rather than to respond reflexively to it. To do so, the nervous system makes use of a modular architecture in which sensory representations are dissociated from areas that control actions. This flexibility however necessitates a recoding scheme that would put sensory information to use in the control of behavior. Sensory recoding faces two important challenges. First, recoding must take into account the inherent variability of sensory responses. Second, it must be flexible enough to satisfy the requirements of different perceptual goals. Recent progress in theory, psychophysics, and neurophysiology indicate that cortical circuitry might meet these challenges by evaluating sensory signals probabilistically.  相似文献   

5.
The pineal organ in the roach, Rutilus rutilus (L.), is covered by a semi-transparent area, the pineal window. Beneath this the pineal is attached to a long robust stalk, lying just under the parietal bone. The pineal is attached to the brain through the dorsal sac. Three cell types have been identified histologically. These are the sensory cells, supporting cells and the ganglia cells. The inner segment of the sensory cells respond to PAS and AF staining, while the remaining cells respond to Orange G, LG, or Acid Fuchsin. The evidence suggests that the roach pineal may have a dual photosensory and glandular function.  相似文献   

6.
Successful healing of skin wounds requires sensory innervation and the release of vasoactive neuropeptides that dilate blood vessels and deliver serum proteins to the wound, and that cause pain that protects from further injury. Activin has been proposed as a target-derived regulator of sensory neuropeptides during development, but its role in the mature nervous system is unknown. While adult skin contains a low level of activin, protein levels in skin adjacent to a wound increase rapidly after an excision. Neurons containing the neuropeptide calcitonin gene-related peptide (CGRP) increased in sensory ganglia that projected to the wounded skin, but not in ganglia that projected to unwounded skin, suggesting that neurons respond to a local skin signal. Indeed, many adult sensory neurons respond with increased CGRP expression to the application of activin in vitro and utilize a smad-mediated signal transduction pathway in this response. A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy. Together, these data support the hypothesis that activin made by skin cells regulates changes in sensory neuropeptides following skin injury, thereby promoting vasodilation and wound healing.  相似文献   

7.
The sensory vesicle of ascidians is thought to be homologous to the vertebrate forebrain and midbrain (Development 125 (1998) 1113). Here we report the isolation of two sensory vesicle markers in the ascidian Ciona intestinalis, which are homologs of vertebrate otx and gsx homeobox genes. By using these markers to analyze the induction of anterior neural tissue in Ciona, we find that the restriction of anterior neural fate to the progeny of the anterior animal blastomeres is due to a combination of two factors. The vegetal blastomeres show a differential inducing activity along the anterior-posterior axis, while the competence to respond to this inducing signal is markedly higher in the anterior animal blastomeres than in the posterior animal blastomeres. This differential competence to respond is also observed in response to bFGF, a candidate neural inducer in ascidians (J. Physiol. 511.2 (1998) 347) and can be detected by the gastrula stage. Our results, however, indicate that bFGF can only induce a subset of the responses of the endogenous inducer, suggesting that additional signals in the embryo are necessary to induce a fully patterned nervous system.  相似文献   

8.
Neurons in posterior parietal cortex of the awake, trained monkey respond to passive visual and/or somatosensory stimuli. In general, the receptive fields of these cells are large and nonspecific. When these neurons are studied during visually guided hand movements and eye movements, most of their activity can be accounted for by passive sensory stimulation. However, for some visual cells, the response to a stimulus is enhanced when it is to be the target for a saccadic eye movement. This enhancement is selective for eye movements into the visual receptive field since it does not occur with eye movements to other parts of the visual field. Cells that discharge in association with a visual fixation task have foveal receptive fields and respond to the spots of light used as fixation targets. Cells discharging selectively in association with different directions of tracking eye movements have directionally selective responses to moving visual stimuli. Every cell in our sample discharging in association with movement could be driven by passive sensory stimuli. We conclude that the activity of neurons in posterior parietal cortex is dependent on and indicative of external stimuli but not predictive of movement.  相似文献   

9.
The behaviour of the sensory- and the ganglia cells in response to inadequate stimuli was studied at 12 adult guinea pigs. The sensory cells of the three Cristae ampullares dont respond remarkably to acoustic stimulation. At the range of 1000 Hz a recognizable increase in the size of the sensory cells at the upper ampulle was noticed. Of no account was the rest of the volume variations. At the range of 5000 Hz the sensory cells of the Maculae staticae responded with a considerable increase in the size of their sensory nuclei up to 38%. The cells of the Ganglion vestibulare react upon acoustic stimulation throughout with an increase in their nuclei up to between 16% and 54%. It was noticed that the volume enlargement increases from the lower to the higher frequencys. The cells of the Ganglion geniculi nervi facialis react upon acoustic impulses too with an increase in their nuclear volume. In low tone acoustic range and in high tone acoustic range the growth rates are more than 50% beyond the standard. Thos cells respond to frequency of 1000 Hz remarkably intensive. It was noticed that the maximum volume increase of their nuclei was in the average up to 103%. All the sensory and ganglia cells react upon rinsing the external auditory canal with 12 degrees C water, with a shrinkage of their nuclei. Besides that the sensory cells of the Cristae and the Maculae show a volume decrease between 8% and 19%. The cells of the Ganglion vestibulare et geniculi respond with a considerable volume decrease of their nuclei from 32 to 41% under the average.  相似文献   

10.
During normal development and following a variety of experimental manipulations (e.g., neural tube rotations, limb shifts), sensory neurons in the chick grow to their correct targets. L. Landmesser and M. G. Honig (1986, Dev. Biol. 118, 511-531) have suggested that sensory innervation may be precise, not because sensory neurons respond to limb-derived guidance cues, but because sensory neurons interact with motoneurons, which do respond to such cues. To test this hypothesis for skin sensory neurons, the ventral neural tube, including the motoneuron precursors, was removed from chick embryos prior to sensory axon outgrowth and the resulting patterns of dermatomes and axonal projections were mapped physiologically and anatomically. As reported previously, dorsal root ganglia (DRGs) and cutaneous nerves formed in their usual locations following the early removal of motoneurons, while most muscle nerves and the plexus region were reduced substantially (A. C. Taylor, 1944, J. Exp. Zool. 96, 159-185; L. Landmesser and M. G. Honig, 1986, Dev. Biol. 118, 511-531; G. J. Swanson and J. Lewis, 1986, J. Embryol. Exp. Morphol. 95, 37-52). The patterns of axonal projections and dermatomes were surprisingly, although not entirely, normal. In particular, cutaneous nerves in motoneuron-depleted embryos were derived from the same DRGs in approximately the same proportions as normal. Thus, while motoneurons may play a facilitative role in the development of the segmental pattern of skin sensory innervation, they do not appear to be essential.  相似文献   

11.
Sensory and non-sensory visual disorders in man and monkey   总被引:1,自引:0,他引:1  
The posterior third of the cerebral cortex in monkeys consists of a patchwork of visual areas in each of which there is a 'map' of the retina. The details of the 'map' vary considerably from one area to another and one notable variation concerns the optimal visual feature to which the cells respond. Orientation, disparity, colour and movement are emphasized in separate areas that appear to be concerned with sensory analysis. Their existence and the possibility that brain damage is occasionally restricted chiefly to one such area may explain the rare highly selective visual sensory impairments that can follow posterior cerebral damage in man. Other areas are notable for having little or no retinotopic representation. Here the cells may have huge receptive fields and complex trigger features. When such regions are removed, the animal's visual sensory abilities are intact but its recognition of patterns and objects is not. This condition resembles human visual agnosia.  相似文献   

12.
Among sensory systems, the somatic sense is exceptional in its ability to detect a wide range of chemical, mechanical and thermal stimuli. How this sensory diversity is established during development remains largely elusive. We devised a method (BAPTISM) that uses the photoconvertible fluorescent protein Kaede to simultaneously analyze birthdate and cell fate in live zebrafish embryos. We found that trigeminal sensory ganglia are formed from early-born and late-born neurons. Early-born neurons give rise to multiple classes of sensory neurons that express different ion channels. By contrast, late-born neurons are restricted in their fate and do not form chemosensory neurons expressing the ion channel TrpA1b. Accordingly, larvae lacking early-born neurons do not respond to the TrpA1b agonist allyl isothiocyanate. These results indicate that the multimodal specification and function of trigeminal sensory ganglia depends on the timing of neurogenesis.  相似文献   

13.
Animals use sensory stimuli to assess and select habitats, mates and food as well as to communicate with other individuals. One way they do this is to use olfaction, whereby they identify and respond to chemical cues. All organisms release odours, which mix with other chemical substances and ambient environmental conditions. The result is that animals are frequently immersed in a complex, highly dynamic sensory environment where they must identify and respond to only some of the potential stimuli they encounter in the face of significant levels of background noise. Understanding how organisms respond to different chemical cues is therefore dependent on knowing how these responses might be influenced by potential interactions with other stimuli. To test this, we examined whether the diadromous fish Galaxias maculatus was attracted to conspecific odours and whether this response differed when cues were offered in an artificial environment lacking other potential chemical stimuli (tap water) or a more natural background environment (stream water). We found that (1) fish responded to both natural stream water odours and those from conspecifics but the response to the latter was stronger; (2) the attraction to conspecific odours was stronger in tap water than in stream water, which indicates the importance of these odours may be overestimated when they are offered in artificial media. We also conducted a brief literature review, which confirmed that artificial media are commonly used in experiments and that the background environment is often not considered. Our results show that future research testing the responses of organisms to auditory, olfactory and visual cues should carefully consider the context in which cues are presented. Without doing so, such studies may inaccurately assess the importance of sensory cues in natural situations in the wild. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.  相似文献   

14.
Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease. Thus, understanding the genomic and cellular mechanisms driving the expression of the TAC1 gene, which encodes SP, in sensory neurones is essential to understanding its role in inflammatory disease. We used a novel combination of computational genomics, primary-cell culture and mouse transgenics to determine the genomic and cellular mechanisms that control the expression of TAC1 in sensory neurones. Intriguingly, we demonstrated that the promoter of the TAC1 gene must act in synergy with a remote enhancer, identified using comparative genomics, to respond to MAPK signalling that modulates the expression of TAC1 in sensory neurones. We also reveal that noxious stimulation of sensory neurones triggers this synergy in larger diameter sensory neurones--an expression of SP associated with hyperalgesia. This noxious stimulation of TAC1 enhancer-promotor synergy could be strongly blocked by antagonism of the MEK pathway. This study provides a unique insight into the role of long-range enhancer-promoter synergy and selectivity in the tissue-specific response of promoters to specific signal transduction pathways and suggests a possible new avenue for the development of novel anti-inflammatory therapies.  相似文献   

15.
16.
The sensory vesicle of ascidians is thought to be homologous to the vertebrate forebrain and midbrain (Development 125 (1998) 1113). Here we report the isolation of two sensory vesicle markers in the ascidian Ciona intestinalis, which are homologs of vertebrate otx and gsx homeobox genes. By using these markers to analyze the induction of anterior neural tissue in Ciona, we find that the restriction of anterior neural fate to the progeny of the anterior animal blastomeres is due to a combination of two factors. The vegetal blastomeres show a differential inducing activity along the anterior-posterior axis, while the competence to respond to this inducing signal is markedly higher in the anterior animal blastomeres than in the posterior animal blastomeres. This differential competence to respond is also observed in response to bFGF, a candidate neural inducer in ascidians (J. Physiol. 511.2 (1998) 347) and can be detected by the gastrula stage. Our results, however, indicate that bFGF can only induce a subset of the responses of the endogenous inducer, suggesting that additional signals in the embryo are necessary to induce a fully patterned nervous system.  相似文献   

17.
Many animals have an abundance and diverse assortment of peripheral sensors, both across and within sensory modalities. Multiple sensors offer many functional advantages to an animal's ability to perceive and respond to environmental signals. Advantages include extending the ability to detect and determine the spatial distribution of stimuli, improving the range and accuracy of discrimination among stimuli of different types and intensities, increasing behavioral sensitivity to stimuli, ensuring continued sensory capabilities when the probability of damage or other loss of function to some sensors is high, maintaining sensory function over the entire sensory surface during development and growth, and increasing the richness of behavioral output to sensory stimulation. In this paper, we use the crustacean chemosensory system as the primary example to discuss these functions of multiple sensors. These principles may be applicable to the function of autonomous robots and should be considered in their design.  相似文献   

18.
Jia L  Emmons SW 《Genetics》2006,173(3):1241-1258
We have studied how a set of male-specific sensory neurons in Caenorhabditis elegans establish axonal connections during postembryonic development. In the adult male, 9 bilateral pairs of ray sensory neurons innervate an acellular fan that serves as a presumptive tactile and olfactory organ during copulation. We visualized ray axon commissures with a ray neuron-specific reporter gene and studied both known and new mutations that affect the establishment of connections to the pre-anal ganglion. We found that the UNC-6/netrin-UNC-40/DCC pathway provides the primary dorsoventral guidance cue to ray axon growth cones. Some axon growth cones also respond to an anteroposterior cue, following a segmented pathway, and most or all also have a tendency to fasciculate. Two newly identified genes, rax-1 and rax-4, are highly specific to the ray neurons and appear to be required for ray axon growth cones to respond to the dorsoventral cue. Among other genes we identified, rax-2 and rax-3 affect anteroposterior signaling or fate specification and rax-5 and rax-6 affect ray identities. We identified a mutation in sax-2 and show that the sax-2/Furry and sax-1/Tricornered pathway affects ectopic neurite outgrowth and establishment of normal axon synapses. Finally, we identified mutations in genes for muscle proteins that affect axon pathways by distorting the conformation of the body wall. Thus ray axon pathfinding relies on a variety of general and more ray neuron-specific genes and provides a potentially fruitful system for further studies of how migrating axon growth cones locate their targets. This system is applicable to the study of mechanisms underlying topographic mapping of sensory neurons into target circuitry where the next stage of information processing is carried out.  相似文献   

19.
Most C. elegans sensory neuron types consist of a single bilateral pair of neurons, and respond to a unique set of sensory stimuli. Although genes required for the development and function of individual sensory neuron types have been identified in forward genetic screens, these approaches are unlikely to identify genes that when mutated result in subtle or pleiotropic phenotypes. Here, we describe a complementary approach to identify sensory neuron type-specific genes via microarray analysis using RNA from sorted AWB olfactory and AFD thermosensory neurons. The expression patterns of subsets of these genes were further verified in vivo. Genes identified by this analysis encode 7-transmembrane receptors, kinases, and nuclear factors including dac-1, which encodes a homolog of the highly conserved Dachshund protein. dac-1 is expressed in a subset of sensory neurons including the AFD neurons and is regulated by the TTX-1 OTX homeodomain protein. On thermal gradients, dac-1 mutants fail to suppress a cryophilic drive but continue to track isotherms at the cultivation temperature, representing the first genetic separation of these AFD-mediated behaviors. Expression profiling of single neuron types provides a rapid, powerful, and unbiased method for identifying neuron-specific genes whose functions can then be investigated in vivo.  相似文献   

20.
Phytochrome photosensory signalling networks   总被引:3,自引:0,他引:3  
Light is life for plants. To continuously assess and adapt to fluctuations in the quality and quantity of this essential commodity, plants deploy sensory photoreceptors, including the phytochromes. Having captured an incoming photon, the activated phytochrome molecule must relay this information to nuclear genes that are poised to respond by directing appropriate adjustments in growth and development. Defining the intricate intracellular signalling networks through which this sensory information is transduced is an area of intense research activity.  相似文献   

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