Whole-Genome Sequencing of the World’s Oldest People

Supercentenarians (110 years or older) are the world’s oldest people. Seventy four are alive worldwide, with twenty two in the United States. We performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity. We found no significant evidence of enrichment for a single rare protein-altering variant or for a gene harboring different rare protein altering variants in supercentenarian compared to control genomes. We followed up on the gene most enriched for rare protein-altering variants in our cohort of supercentenarians, TSHZ3, by sequencing it in a second cohort of 99 long-lived individuals but did not find a significant enrichment. The genome of one supercentenarian had a pathogenic mutation in DSC2, known to predispose to arrhythmogenic right ventricular cardiomyopathy, which is recommended to be reported to this individual as an incidental finding according to a recent position statement by the American College of Medical Genetics and Genomics. Even with this pathogenic mutation, the proband lived to over 110 years. The entire list of rare protein-altering variants and DNA sequence of all 17 supercentenarian genomes is available as a resource to assist the discovery of the genetic basis of extreme longevity in future studies.     

How was Membrane Permeability Produced in an RNA World?

Darwinian evolution in an RNA World required that catalysts be encapsulated in membranes since this would allow superior catalysts to benefit from the products of their own reactions. However, typical membranes are relatively impermeable to polar and complex molecules and, thus, even primitive cells had to have RNA-based mechanisms for the uptake of external nutrients and the excretion of waste products. Nucleic acids form weak non-specific contacts with the surface of the lipid membrane in the presence of divalent cations, and strongly binding species can be obtained in the course of SELEX experiments. The only currently suggested mechanism for the production of permeability is through formation of supramolecular RNA complexes capable of destabilizing and transiently opening lipid membranes by action from one side, but neither natural nor selected examples of RNA channels or transmembrane shuttles are known so far. The necessity to evolve proteins could be strongly driven by the need to build defined hydrophobic structures that when integrated into membranes could provide selective permeability.     

Young ISHAM – Uniting Young Scientists from all over the World

The Young section of the International Society of Human and Animal Mycology (= Young ISHAM), was established for connecting young scientists and representing their needs within the society. Discussing practical issues and providing support helps especially PhD student dealing with ups and downs in science. We are developing resources related to scientific publishing and reviewing, publishing ethics, funding and grant application skills, career building, and presentation techniques. Young ISHAM will help younger scientists in all aspects of their scientific career, to ensure that a new generation of medical mycologists is prepared to engage with the challenges within our field.     

Human Proteome Organisation’s 7th World Congress, 2008

The annual world congress of Human Proteome Organisation (HUPO) is one of the premier meetings in proteomics. Rotating between Europe, North America and Asia/Oceana, this year’s host city was Amsterdam, The Netherlands. Proteomics still being a rapidly evolving field, HUPO meetings provide a platform for technical advancements in protein purification and separation techniques, innovations in mass spectrometry and applications in bioinformatics and computational biology. A special focus of this year’s meeting was on proteome biology, indicating that the state of technology has progressed to a level permitting interrogation of biological systems in a meaningful way.     

Can Natural World Heritage Sites promote development and social harmony?

UNESCO designates the areas of biological, geological, and evolutionary importance all over the world as the Natural World Heritage Sites (sites). These sites are all unique, but not equally popular with the tourists. This study quantifies the effect of population, percapita income, and number, area and access on the number of visitors to the sites. The results suggest that good infrastructure for tourism and civil order may be more important than population or income for the number of visitors. The study identifies the policies and institutions that can increase the popularity of the sites. It argues that the sites can promote development, build consensus on conservation, and advance social harmony.     

The World Medical Association: can hope triumph over experience?

The World Medical Association was set up in 1947 in the wake of outrage about war crimes committed by doctors in Hitler''s Germany. For nearly 50 years it has lurched from one controversy to another, arguing within itself about its funding, its voting system, and the representativeness and political affiliation of some of its member medical associations. The BMA withdrew from the association in 1984, supporting a breakaway "Toronto" group including Canada, the Scandinavian countries, the Netherlands, Ireland, and Jamaica. All but Britain and Jamaica have now rejoined and membership is growing, but the association is still struggling to gain credibility and clout. After 20 years of part time stewardship the recent appointment of a new full time secretary general has fuelled expectations that internal reforms will be implemented, and the WMA''s standing and profile improved.     

Jiuzhaigou, The World Natural Heritage and the member of CBRN

For thousands of years, Jiuzhaigou was hidden in the mountain ranges of the plateau northwest of Sichuan. It was left to the hand of nature and human activities seemed insignificant. For a long time, there were only narrow paths for horse travels and the local Tibetans lived a self-sufficient     

‘Threatened Fishes of The World’ Series, an Update

The series of one-page articles on the Threatened fishes of the world was launched in 1995 (Bruton 1995, Moyle & Moyle 1995). Since then ichthyologists and fish biologists throughout the world have contributed 97 articles (Environmental Biology of Fishes vol. 43–57, Table 1). In 15 volumes of the journal 37 families have been so far included. The largest number of contributions was on species in the family Cyprinidae (23) followed by Galaxiidae (8). Eighty-four contributions have been on freshwater, seven on estuarine and six on marine fish species (Table 2).     

Morningness‐Eveningness Comparison in Adolescents from Different Countries around the World

Very few studies have focused on differences in chronotype around the globe. In this study, morningness‐eveningness was measured using the Composite Scale of Morningness and the midpoint of sleep on free days (corrected for sleep debt, MSF_sc) in adolescents of sixteen German schools abroad, dispersed all over the world, and for comparison pupils attending German schools. There was no influence of duration of residence in the respective locality, and sex differences were weak. Age correlated negatively with morningness. A significant influence of climate zone (temperate, subtropics, tropics) was found, with adolescents in the subtropics being the latest chronotypes, and an interaction of age×climate zone was identified. Significant associations between chronotype and longitude and latitude were identified within the time zone of central Europe. Adolescents were found to be more morning oriented both toward the East and North. The results indicate that climate, longitude, and latitude contribute to chronotype.     

What is the purpose of launching World Journal of Biological Chemistry?

The first issue of World Journal of Biological Chemistry (WJBC), whose preparatory work was initiated on July 01, 2009, will be published on January 26, 2010. The WJBC Editorial Board has now been established and consists of 341 distinguished experts from 37 countries. Our purpose of launching WJBC is to publish peer-reviewed, high-quality articles via an open-access online publishing model, thereby acting as a platform for communication between peers and the wider public, and maximizing the benefits to editorial board members, authors and readers.