共查询到20条相似文献,搜索用时 31 毫秒
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Francesco Ria Romina Penitente Maria De Santis Chiara Nicolò Gabriele Di Sante Massimiliano Orsini Dario Arzani Andrea Fattorossi Alessandra Battaglia Gian Franco Ferraccioli 《Arthritis research & therapy》2008,10(6):R135
Introduction
Type II collagen is a DR4/DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at different phases in rheumatoid arthritis. 相似文献4.
Background
In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in gastrulating embryos, is unknown, but a recent study has claimed that it plays a central role in germ cell specification. 相似文献5.
Background
Constraint-based models enable structured cellular representations in which intracellular kinetics are circumvented. These models, combined with experimental data, are useful analytical tools to estimate the state exhibited (the phenotype) by the cells at given pseudo-steady conditions. 相似文献6.
Johanna Roostalu Arvi Jõers Hannes Luidalepp Niilo Kaldalu Tanel Tenson 《BMC microbiology》2008,8(1):68
Background
A fundamental characteristic of cells is the ability to divide. To date, most parameters of bacterial cultures, including cell division, have been measured as cell population averages, assuming that all bacteria divide at a uniform rate. 相似文献7.
Daniel Sperandio Gaelle Rossignol Josette Guerillon Nathalie Connil Nicole Orange Marc GJ Feuilloley Annabelle Merieau 《BMC microbiology》2010,10(1):124
Background
MFN1032 is a clinical Pseudomonas fluorescens strain able to grow at 37°C. MFN1032 cells induce necrosis and apoptosis in rat glial cells at this temperature. This strain displays secretion-mediated hemolytic activity involving phospholipase C and cyclolipopeptides. Under laboratory conditions, this activity is not expressed at 37°C. This activity is tightly regulated and is subject to phase variation. 相似文献8.
Bioaccumulation and toxicity of selenium compounds in the green alga Scenedesmus quadricauda 总被引:1,自引:0,他引:1
Dáša Umysová Milada Vítová Irena Doušková Kateřina Bišová Monika Hlavová Mária Čížková Jiří Machát Jiří Doucha Vilém Zachleder 《BMC plant biology》2009,9(1):58-16
Background
Selenium is a trace element performing important biological functions in many organisms including humans. It usually affects organisms in a strictly dosage-dependent manner being essential at low and toxic at higher concentrations. The impact of selenium on mammalian and land plant cells has been quite extensively studied. Information about algal cells is rare despite of the fact that they could produce selenium enriched biomass for biotechnology purposes. 相似文献9.
Fujii Y Tomita K Sano H Yamasaki A Hitsuda Y Adcock IM Shimizu E 《Cancer cell international》2002,2(1):16-11
Background
Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs), the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidative stress. We compared the extent of oxidative DNA damage with that of mitochondrial injury in lung epithelial cells at the single cell level. 相似文献10.
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Elisa Tinazzi Marzia Dolcino Antonio Puccetti Antonella Rigo Ruggero Beri Maria Teresa Valenti Roberto Corrocher Claudio Lunardi 《Arthritis research & therapy》2010,12(4):R131-15
Introduction
Circulating endothelial cells are increased in patients affected by systemic sclerosis (SSc) and their number strongly correlates with vascular damage. The effects of iloprost in systemic sclerosis are only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression in patients with systemic sclerosis. 相似文献12.
M Evangelina Pablo-Hernando Yolanda Arnaiz-Pita Hiroyuki Tachikawa Francisco del Rey Aaron M Neiman Carlos R Vázquez de Aldana 《BMC cell biology》2008,9(1):55
Background
In Saccharomyces cerevisiae, nutrient limitation stimulates diploid cells to undergo DNA replication and meiosis, followed by the formation of four haploid spores. Septins are a family of proteins that assemble a ring structure at the mother-daughter neck during vegetative growth, where they control cytokinesis. In sporulating cells, the septin ring disassembles and septins relocalize to the prospore membrane. 相似文献13.
Kelly J Langford Jon M Askham Tracy Lee Matthew Adams Ewan E Morrison 《BMC cell biology》2006,7(1):3-18
Background
The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular junctions has been previously presented, though live imaging of mammalian junctional APC has not been documented. 相似文献14.
Telomere length determined by the fluorescence in situ hybridisation distinguishes malignant and benign cells in cytological specimens
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Y. Matsuda A. Suzuki S. Esaka Y. Hamashima M. Imaizumi M. Kinoshita H. Shirahata Y. Kiso H. Kojima M. Matsukawa Y. Fujii N. Ishikawa J. Aida K. Takubo T. Ishiwata M. Nishimura T. Arai 《Cytopathology》2018,29(3):262-266
Background
Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes that play a key role in preventing chromosomal instability. The aim of the present study is to determine telomere length using fluorescence in situ hybridisation (FISH) on cytological specimens.Methods
Aspiration samples (n = 41) were smeared on glass slides and used for FISH.Results
Telomere signal intensity was significantly lower in positive cases (cases with malignancy, n = 25) as compared to negative cases (cases without malignancy, n = 16), and the same was observed for centromere intensity. The difference in DAPI intensity was not statistically significant. The ratio of telomere to centromere intensity did not show a significant difference between positive and negative cases. There was no statistical difference in the signal intensities of aspiration samples from ascites or pleural effusion (n = 23) and endoscopic ultrasound‐guided FNA samples from the pancreas (n = 18).Conclusions
The present study revealed that telomere length can be used as an indicator to distinguish malignant and benign cells in cytological specimens. This novel approach may help improve diagnosis for cancer patients. 相似文献15.
Ralph Brandenberger Irina Khrebtukova R Scott Thies Takumi Miura Cai Jingli Raj Puri Tom Vasicek Jane Lebkowski Mahendra Rao 《BMC developmental biology》2004,4(1):10
Background
Pooled human embryonic stem cells (hESC) cell lines were profiled to obtain a comprehensive list of genes common to undifferentiated human embryonic stem cells. 相似文献16.
Background
A method for inhibiting the expression of particular genes using external guide sequences (EGSs) has been developed in bacteria, mammalian cells and maize cells. 相似文献17.
Célia Regina Moreira Lanza Carlos Alberto de Souza Costa Maysa Furlan Alberto Alécio Josimeri Hebling 《Cell biology and toxicology》2009,25(6):533-543
Objective
To evaluated the transdentinal diffusion and subsequent cytotoxicity of self-etching adhesives on odontoblast-like cells. 相似文献18.
Chiara Chiellini Olivia Cochet Luc Negroni Michel Samson Marjorie Poggi Gérard Ailhaud Marie-Christine Alessi Christian Dani Ez-Zoubir Amri 《BMC molecular biology》2008,9(1):26
Background
It is well established that adipose tissue plays a key role in energy storage and release but is also a secretory organ and a source of stem cells. Among different lineages, stem cells are able to differentiate into adipocytes and osteoblasts. As secreted proteins could regulate the balance between both lineages, we aimed at characterizing the secretome of human multipotent adipose-derived stem cell (hMADS) at an early step of commitment to adipocytes and osteoblasts. 相似文献19.
Tiziana Angrisano Raffaela Pero Silvia Peluso Simona Keller Silvana Sacchetti Carmelo B Bruni Lorenzo Chiariotti Francesca Lembo 《BMC microbiology》2010,10(1):172