共查询到20条相似文献,搜索用时 31 毫秒
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Aberrant expression of aromatase in breast cancer tissues 总被引:4,自引:0,他引:4
Nobuhiro Harada 《The Journal of steroid biochemistry and molecular biology》1997,61(3-6):175-184
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Tanaka M Yamamoto I Hayashida Y Nakao N Ohkubo T Wakita M Nakashima K 《Biochimica et biophysica acta》2000,1491(1-3):279-284
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Mancl ME Hu G Sangster-Guity N Olshalsky SL Hoops K Fitzgerald-Bocarsly P Pitha PM Pinder K Barnes BJ 《The Journal of biological chemistry》2005,280(22):21078-21090
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HIV-1 infections lead to a progressive depletion of CD4 cells culminating in AIDS. The coreceptor usage by HIV varies from CCR5 (R5) tropic early in infection to CXCR4 (X4) tropic in later infections. Although the coreceptor switch from R5 to X4 tropic HIV is well associated with progression to AIDS, the role of CCR5 in disease progression especially in patients infected exclusively with R5 isolates throughout the disease remains enigmatic. To better understand the role of CCR5 and R5 tropic HIV envelope in AIDS pathogenesis, we asked whether the levels of CCR5 and/or HIV Env-mediated fusion determine apoptosis of bystander cells. We generated CD4(+) T cell lines expressing varying levels of CCR5 on the cell surface to show that CCR5 expression levels correlate with bystander apoptosis induction. The mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization and was dependent on gp41 fusion activity as confirmed by fusion-restricted gp41 point mutants and use of the fusion inhibitor T20. Interestingly, lower levels of CCR5 were able to support virus replication in the absence of bystander apoptosis. Our findings suggest that R5 HIV-1-mediated bystander apoptosis is dependent on both CCR5 expression levels as well as fusogenic activity of the Env glycoprotein. 相似文献
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Characterization of the upstream mouse Cbfa1/Runx2 promoter 总被引:9,自引:0,他引:9
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