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《基因组学与应用生物学》2017,(1)
红头美洲鹫(Cathartes aura)是美洲鹫科的一种食腐鸟类,已知腐肉中有许多致病细菌可致肉食动物或者杂食动物中毒甚至死亡,然而红头美洲鹫并不受此影响。为探究红头美洲鹫可能发生了哪些与食腐特性相关的适应性改变,我们结合红头美洲鹫和白头海雕(Haliaeetus leucocephalus)的基因组数据进行比较研究,对筛选的快速进化基因分别进行注释和富集分析。结果显示,多数快速进化基因被富集到与免疫、能量代谢和消化相关的通路上;此外,有5个基因被富集到与嗅觉相关的"嗅觉转导"通路上。本研究表明,红头美洲鹫体内与免疫、能量代谢和消化相关的基因可能发生了与食腐特性相适应的快速进化,说明其可能从多个层面已形成一套很强的防御系统以抵御病菌的危害;与嗅觉相关的5个基因的快速进化可能与其在觅食过程中快速探测到腐肉气味密切相关。 相似文献
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《小哥白尼(野生动物画报)》2018,(9)
正说起从古到今活跃在各路小说中的奇幻生物,免不了要提到龙啊、凤凰啊这些。不过,光是它们显然满足不了好奇的哥迷们。最近,就有哥迷给火狐狸姐姐砸来了一连串问题,大部分都和奇幻生物有关。名气仅次于龙和凤凰的奇幻生物是谁?这个问题问得有水平。古往今来,故事圈里的作者们都为此争论过,有人说是雪人,有人说是独角兽,也有人说是狮鹫。现在,公认的第三名奇幻动物是狮鹫。它长有狮子的躯体与利爪、鹰的头和翅膀,因为狮子和鹰分别称雄于陆地和天空,所以狮鹫很自然地被认为是霸主型生物。许多畅销游戏中部有它的身影。 相似文献
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《小哥白尼(野生动物画报)》2011,(6)
卡索是一只居住在南美森林的国王秃鹫(又名王鹫),瞧,就是旁边这个涂着橘色腮红,长相怪异的家伙。由于名字中带个王字,再加上个头在秃鹫家族中位列前三,卡索常常会萌生出一种高鹫一等的优越感,甚至把自己幻想成统治南美森林的国王。这不,最近一段时间,卡索的国王幻想症又发作了,它萌生出遨游南美森林、巡视统治国土的想法。瞧,高傲的国王,它出发了! 相似文献
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Ari Helenius 《Molecular biology of the cell》2012,23(21):4157-4159
The fluid mosaic model for biological membranes was formulated 40 years ago. Ten years later endosomes were discovered as important prelysosomal organelles. At the outset of my research career, I was fortunate to witness both these turning points in biochemistry and cell biology from close up, and to participate in some of the studies. In this short essay, I will describe how this came about, and also try to provide some background as to the general starting situation in those not so distant pioneering years of membrane biology. 相似文献
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Rosenfeld S 《Progress in biophysics and molecular biology》2011,106(2):400-409
In this paper, we review some fundamental aspects, as well as some new developments, in the emerging field of network biology. The focus of attention is placed on mathematical approaches to conceptual modeling of biomolecular networks with special emphasis on dynamic stability, stochasticity and evolution. 相似文献
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As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries for completion of their replication cycle. The recent discovery of the heterogeneous distribution of the various lipids within cell membranes has led to the proposal that sphingolipids and cholesterol tend to segregate in microdomains called membrane rafts. The involvement of membrane rafts in biosynthetic traffic, signal transduction, and endocytosis has suggested that viruses may also take advantage of rafts for completion of some steps of their replication cycle, such as entry into their cell host, assembly, and budding. In this review, we have attempted to delineate all the reliable data sustaining this hypothesis and to build some models of how rafts are used as platforms for assembly of some viruses. Indeed, if in many cases a formal proof of raft involvement in a virus replication cycle is still lacking, one can reasonably suggest that, owing to their ability to specifically attract some proteins, lipid microdomains provide a particular milieu suitable for increasing the efficiency of many protein-protein interactions which are crucial for virus infection and growth. 相似文献
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Virus entry, assembly, budding, and membrane rafts. 总被引:3,自引:0,他引:3
Nathalie Chazal Denis Gerlier 《Microbiology and molecular biology reviews》2003,67(2):226-37, table of contents
As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries for completion of their replication cycle. The recent discovery of the heterogeneous distribution of the various lipids within cell membranes has led to the proposal that sphingolipids and cholesterol tend to segregate in microdomains called membrane rafts. The involvement of membrane rafts in biosynthetic traffic, signal transduction, and endocytosis has suggested that viruses may also take advantage of rafts for completion of some steps of their replication cycle, such as entry into their cell host, assembly, and budding. In this review, we have attempted to delineate all the reliable data sustaining this hypothesis and to build some models of how rafts are used as platforms for assembly of some viruses. Indeed, if in many cases a formal proof of raft involvement in a virus replication cycle is still lacking, one can reasonably suggest that, owing to their ability to specifically attract some proteins, lipid microdomains provide a particular milieu suitable for increasing the efficiency of many protein-protein interactions which are crucial for virus infection and growth. 相似文献
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Jack R. Lancaster Jr. 《Journal of bioenergetics and biomembranes》1989,21(6):717-740
In this review, I focus on the bioenergetics of the methanogenic bacteria, with particular attention directed to the roles of transmembrane electrochemical gradients of sodium and proton. In addition, the mechanism of coupling ATP synthesis to methanogenic electron transfer is addressed. Evidence is reviewed which suggests that the methanogens possess great diversity in their bioenergetic machinery. In particular, in some methanogens the primary ion which is translocated coupled to metabolic energy is the proton, while others appear to utilize sodium. In addition, ATP synthesis driven by methanogenic electron transfer is accomplished in some organisms by a chemiosmotic mechanism and is coupled by a more direct mechanism in others. A possible explanation for this diversity (which is consistent with the relatedness of these organisms to each other and to other members of the Archaebacteria as determined by molecular biological techniques) is discussed. 相似文献
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Krylov VN 《Genetika》2001,37(7):869-887
The appearance and spreading of multidrug-resistant bacterial pathogens is a consequence of the large-scale use of antibiotics in medicine. In view of this, claims for the phage therapy were renewed: in recent studies, the natural phages and their products neutralizing various proteins, as well as the bacterial products often controlled by defective prophages (bacteriocins) were applied for treatment of bacterial infections. Constructs obtained by gene engineering are increasingly used to change some bacteriophage: properties to expand the spectrum of their lytic activity and to eliminate therapeutic drawbacks of some natural phages. In this review, the problem of phage therapy is discussed in general with respect to bacteriophage properties, their genetics, structure, evolution, taking into account long-term experience of the author in the field of bacteriophage genetics. Note that the general concept of phage therapy should be developed to ensure long-term, efficient and harmless phage therapy. 相似文献
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Kamal A Murty JN Viswanath A Sujitha P Ganesh Kumar C 《Bioorganic & medicinal chemistry letters》2012,22(14):4891-4895
In this letter, we describe the first synthesis of two recently isolated flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and anticancer activities. Most of the synthesized compounds exhibited antimicrobial activity against the tested microbial strains and some of these compounds were found to be more potent as compared to the standard drugs like neomycin and luteolin. Interestingly, some of these synthesized compounds also showed moderate antioxidant property. 相似文献
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ISAM 9 (International Symposium of Arctic-Alpine Mycology) was held in August 2012?at the Kevo Lapland Research Station in Utsjoki in northernmost Finnish Lapland. In addition to Utsjoki, some excursions were made in Finnmark, the northernmost part of Norway. Kevo station lies in the subarctic zone characterized by mountain birch (Betula pubescens var. czerepanovii), but the fells reach the arctic tundra zone. Áilegas fells at Utsjoki village and at Nuvvus lie on acid ground as does Skalluvaara, and all are under influence of reindeer grazing. The Gistuskaidi fell is highest and is characterized by the presence of more basic rocks; the vegetation also reflects some amount of maritime influence. The places visited on the Norwegian side belong to the Nesseby commune at the sea shore and Tana commune on the shore of the Tana River and along the road to Båtsfjord where the tundra is maritime and mossy with calcareous spots. In all 123 taxa were found during the excursions, some of them not determined at species level. The reported fungal taxa belong to the Basidiomycota (115 taxa), Ascomycota (7 taxa), and Mycetozoa (1 taxon). 相似文献
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甘肃东乡龙担的河狸(啮齿类,哺乳动物)化石——龙担哺乳动物群补充报道之一 总被引:3,自引:3,他引:0
报道了在甘肃省首次发现的河狸化石:安氏河狸(Castor anderssoni)。安氏河狸在甘肃东乡的发现,扩大了河狸化石在我国的分布范围,并进一步证明龙担地点的黄土的时代为早于2Ma的早更新世。对现生河狸生存环境的对比分析表明,东乡地区在早更新世时可能比现在更湿冷,河、湖广布,树木较多,与现在温带半干旱气候的黄土丘陵地区的气候和环境差别很大。这种差别很可能是青藏高原后期抬升的结果。 相似文献