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Cloning and characterization of a novel gene（C17orf25）from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma 总被引：2，自引：0，他引：2
Qin WX Wan F Sun FY Zhang PP Han LW Huang Y Jiang HQ Zhao XT He M Ye Y Cong WM Wu MC Zhang LS Yang NW Gu JR 《Cell research》2001,11(3):209-216
INTRODUCTIONLoss of heterozygosity (LOH) at chromosoma1loci associated with tumor suppressor genes has beenimplicated in the genesis of many types of humanmalignancies. On the basis of frequent LOH in tu-mors, coupled with linkage analysis in some heredi-tary cancer syndromes, a number of tumor suppres-sor genes, such as RB[l], DCC[2], NF2[3], VHLI4],MTh1[5], DML/OM1[6], and PrsN/rmC1[7l have been successively isolated.It has beell reported that LOH occurred at l7p invarious ty… 相似文献