共查询到20条相似文献,搜索用时 31 毫秒
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Regulation of Smad7 promoter by direct association with Smad3 and Smad4 总被引:26,自引:0,他引:26
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Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis 总被引:8,自引:0,他引:8
Yamamura Y Hua X Bergelson S Lodish HF 《The Journal of biological chemistry》2000,275(46):36295-36302
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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts 总被引:12,自引:0,他引:12
Piek E Ju WJ Heyer J Escalante-Alcalde D Stewart CL Weinstein M Deng C Kucherlapati R Bottinger EP Roberts AB 《The Journal of biological chemistry》2001,276(23):19945-19953
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The interleukin 2 receptor alpha chain (IL-2Ralpha) is a component of high affinity IL-2 receptors and thus critically regulates T cell growth and other lymphoid functions. Five positive regulatory regions together control lineage-restricted and activation-dependent IL-2Ralpha induction in response to antigen and IL-2. We now show that TGF-beta cooperates with T cell receptor (TCR) signaling to increase IL-2Ralpha gene expression. Moreover, we identify a sixth positive regulatory region that regulates IL-2Ralpha expression in cells treated with anti-CD3 + anti-CD28 as well as TGF-beta and show that this region contains binding sites for Smad3, AP-1, and cAMP-responsive element-binding protein/ATF proteins. The importance of Smad complexes is indicated by impaired IL-2Ralpha induction by TGF-beta in CD4+ T cells from both Smad3-/- and Smad4-/- mice. Thus, we have identified a novel positive regulatory region in the IL-2Ralpha gene that mediates TGF-beta-dependent induction of the gene. These findings have implications related to IL-2Ralpha expression on activated T cells and regulatory T cells. 相似文献
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Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex. 总被引:7,自引:5,他引:2 下载免费PDF全文
M C Birchenall-Roberts F W Ruscetti J Kasper H D Lee R Friedman A Geiser M B Sporn A B Roberts S J Kim 《Molecular and cellular biology》1990,10(9):4978-4983
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TGF-beta signaling from receptors to the nucleus 总被引:13,自引:0,他引:13
Roberts AB 《Microbes and infection / Institut Pasteur》1999,1(15):1265-1273