共查询到20条相似文献,搜索用时 18 毫秒
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Nicolas Nègre Christopher D. Brown Parantu K. Shah Pouya Kheradpour Carolyn A. Morrison Jorja G. Henikoff Xin Feng Kami Ahmad Steven Russell Robert A. H. White Lincoln Stein Steven Henikoff Manolis Kellis Kevin P. White 《PLoS genetics》2010,6(1)
Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities of metazoan gene regulation. We studied by ChIP–chip the genome-wide binding sites of 6 insulator-associated proteins—dCTCF, CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF—to obtain the first comprehensive map of insulator elements in Drosophila embryos. We identify over 14,000 putative insulators, including all classically defined insulators. We find two major classes of insulators defined by dCTCF/CP190/BEAF-32 and Su(Hw), respectively. Distributional analyses of insulators revealed that particular sub-classes of insulator elements are excluded between cis-regulatory elements and their target promoters; divide differentially expressed, alternative, and divergent promoters; act as chromatin boundaries; are associated with chromosomal breakpoints among species; and are embedded within active chromatin domains. Together, these results provide a map demarcating the boundaries of gene regulatory units and a framework for understanding insulator function during the development and evolution of Drosophila. 相似文献
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Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome 总被引:31,自引:0,他引:31
Kim TH Abdullaev ZK Smith AD Ching KA Loukinov DI Green RD Zhang MQ Lobanenkov VV Ren B 《Cell》2007,128(6):1231-1245
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CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator 总被引:8,自引:0,他引:8
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Moon H Filippova G Loukinov D Pugacheva E Chen Q Smith ST Munhall A Grewe B Bartkuhn M Arnold R Burke LJ Renkawitz-Pohl R Ohlsson R Zhou J Renkawitz R Lobanenkov V 《EMBO reports》2005,6(2):165-170
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