共查询到20条相似文献,搜索用时 15 毫秒
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The basics of determining valuation will help you to understand what criteria matter most for investors. 相似文献
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Getting to know protein kinase D 总被引:7,自引:0,他引:7
Lint JV Rykx A Vantus T Vandenheede JR 《The international journal of biochemistry & cell biology》2002,34(6):577-581
The protein kinase D (PKD) enzymes represent a new family of second messenger stimulated kinases, with diacylglycerol as a prime, but not the sole, mediator of activation. Their molecular architecture features a catalytic domain, unrelated to that of all PKC family members, and a large inhibitory, regulatory domain, comprised of two Zinc fingers, and a pleckstrin homology domain. These different sub-domains play distinctive roles in the activation, translocation and biological functions of the kinase. The enzymes have been implicated in signalling mechanisms controlling cell proliferation and programmed cell death and in metastasis, immune responses, and Golgi restructuring and function. A variety of proteins specifically interact with the different sub-domains of the enzymes and direct their wide range of cellular functions. 相似文献
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Get to know your stem cells 总被引:9,自引:0,他引:9
Our view of the central nervous system has changed dramatically over the past few years. It is now well established that new neurons are generated continuously in adult mammals, including humans. These neurons derive from self-renewing multipotent neural stem cells. The identify of these stem cells has recently been unveiled. 相似文献
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Bruno Antonny Christopher Burd Pietro De Camilli Elizabeth Chen Oliver Daumke Katja Faelber Marijn Ford Vadim A Frolov Adam Frost Jenny E Hinshaw Tom Kirchhausen Michael M Kozlov Martin Lenz Harry H Low Harvey McMahon Christien Merrifield Thomas D Pollard Phillip J Robinson Aurélien Roux Sandra Schmid 《The EMBO journal》2016,35(21):2270-2284
The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it plays a critical role in many physiological functions such as synaptic transmission and muscle contraction. Research of the past three decades has focused on understanding how dynamin works. In this review, we present the basis for an emerging consensus on how dynamin functions. Three properties of dynamin are strongly supported by experimental data: first, dynamin oligomerizes into a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin catalyzes membrane fission upon GTP hydrolysis. We present the two current models for fission, essentially diverging in how GTP energy is spent. We further discuss how future research might solve the remaining open questions presently under discussion. 相似文献
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Wallace F 《BMJ (Clinical research ed.)》2001,322(7282):366
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《生物化学与生物物理学报:癌评论》2022,1877(5):188796
Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management. 相似文献
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Balmford A Green R Phalan B 《Proceedings. Biological sciences / The Royal Society》2012,279(1739):2714-2724
Farming is the basis of our civilization yet is more damaging to wild nature than any other sector of human activity. Here, we propose that in order to limit its impact into the future, conservation researchers and practitioners need to address several big topics--about the scale of future demand, about which crops and livestock to study, about whether low-yield or high-yield farming has the potential to be least harmful to nature, about the environmental performance of new and existing farming methods, and about the measures needed to enable promising approaches and techniques to deliver on their potential. Tackling these issues requires conservationists to explore the many consequences that decisions about agriculture have beyond the farm, to think broadly and imaginatively about the scale and scope of what is required to halt biodiversity loss, and to be brave enough to test and when necessary support counterintuitive measures. 相似文献
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In vitro selection, or SELEX, is a technique that allows the simultaneous screening of highly diverse pools of different RNA or DNA (dsDNA or ssDNA) molecules for a particular feature. Different examples from a great variety of applications ofin vitro selection experiments are described and a detailed overview of the method and its variations will be given. Some especially conclusivein vitro selection experiments are discussed in detail to illustrate the potential power and diversity of this method. Potential restrictions of the methods and possible ways to overcome them are pointed out. 相似文献
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Zinc finger proteins: what we know and what we would like to know. 总被引:14,自引:0,他引:14
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