共查询到20条相似文献,搜索用时 172 毫秒
1.
Andreas K Lübke C Häupl T Dehne T Morawietz L Ringe J Kaps C Sittinger M 《Arthritis research & therapy》2008,10(1):R9
Background
Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic autoimmune disease that leads to progressive cartilage destruction. Advances in the treatment of RA-related destruction of cartilage require profound insights into the molecular mechanisms involved in cartilage degradation. Until now, comprehensive data about the molecular RA-related dysfunction of chondrocytes have been limited. Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes. 相似文献2.
Introduction
Hypoxia is a feature of the inflamed synovium in rheumatoid arthritis (RA). Intra-articular injection of hyaluronan (HA) may be considered a potential way to treat RA. However, the exact molecular mechanism of HA on decreased cellular responses to hypoxic environment is unclear. The present study has been designed to use the adjuvant-induced arthritis model to examine the effects of HA on the changes of immunohistochemical expressions of hypoxia-inducible factor-1alpha (HIF-1alpha), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-3 (MMP3) in the synovial tissues at the early phase of arthritic inflammation. 相似文献3.
Olivier Jaen Elisabeth Petit-Teixeira Holger Kirsten Peter Ahnert Luca Semerano Céline Pierlot Francois Cornelis Marie-Christophe Boissier Geraldine Falgarone 《Arthritis research & therapy》2009,11(1):R5-10
Introduction
The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host–pathogen interactions are involved in RA physiopathology. 相似文献4.
Chandra PE Sokolove J Hipp BG Lindstrom TM Elder JT Reveille JD Eberl H Klause U Robinson WH 《Arthritis research & therapy》2011,13(3):R102
Introduction
The aim of this study was to develop a clinical-grade, automated, multiplex system for the differential diagnosis and molecular stratification of rheumatoid arthritis (RA). 相似文献5.
Stavropoulos-Kalinoglou A Metsios GS Panoulas VF Douglas KM Nevill AM Jamurtas AZ Kita M Koutedakis Y Kitas GD 《Arthritis research & therapy》2008,10(3):R59
Introduction
Rheumatoid arthritis (RA) is associated with altered metabolism leading to muscle wasting. In the general population, cigarette smoking is known to affect body composition by reducing fat and inhibiting muscle synthesis. Even though smoking has been implicated in the pathophysiology and progression of RA, its possible effects on body composition of such patients have not been studied. This cross-sectional study aimed to identify potential associations of smoking with body weight and composition of RA patients. 相似文献6.
Lee HM Sugino H Aoki C Shimaoka Y Suzuki R Ochi K Ochi T Nishimoto N 《Arthritis research & therapy》2011,13(3):R89
Introduction
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis that progresses to destruction of cartilage and bone. Bone marrow (BM) cells have been shown to contribute to this pathogenesis. In this study, we compared differentially expressed molecules in BM cells from RA and osteoarthritis (OA) patients and analyzed abnormal regulatory networks to identify the role of BM cells in RA. 相似文献7.
Wei Zhang Nick Bansback Annelies Boonen Adam Young Amitabh Singh Aslam H Anis 《Arthritis research & therapy》2010,12(5):R177
Introduction
The Work Productivity and Activity Impairment (WPAI) questionnaire is a well validated instrument to measure impairments in work and activities. However, its validation among patients with rheumatoid arthritis (RA) has not been well established. The present study's purpose is to evaluate the construct validity of the WPAI-general health version among RA patients and its ability to differentiate between RA patients with varying health status. 相似文献8.
Kim SY Servi A Polinski JM Mogun H Weinblatt ME Katz JN Solomon DH 《Arthritis research & therapy》2011,13(1):R32
Introduction
Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in these data has been inconsistent. 相似文献9.
Manathip Osiri Jeerapat Wongchinsri Sitthichai Ukritchon Punchong Hanvivadhanakul Nuntana Kasitanon Boonjing Siripaitoon 《Arthritis research & therapy》2009,11(4):R129-8
Introduction
The Health Assessment Questionnaire Disability Index (HAQ-DI) is a commonly used instrument to assess functional status of patients with rheumatoid arthritis (RA). Translations and adaptations of the HAQ-DI have been carried out for use with RA patients in several countries. The objective of this study was to evaluate the psychometric properties of the Thai version of the HAQ-DI (Thai HAQ) in Thai patients with RA. 相似文献10.
Toshihiro Nanki Kazuki Takada Yukiko Komano Tomohiro Morio Hirokazu Kanegane Atsuo Nakajima Peter E Lipsky Nobuyuki Miyasaka 《Arthritis research & therapy》2009,11(5):R149-11
Introduction
Accumulation of B cells in the rheumatoid arthritis (RA) synovium has been reported, and it has been thought that these cells might contribute to the pathogenesis of RA by antigen presentation, autoantibody production, and/or inflammatory cytokine production. Chemokines could enhance the accumulation of B cells in the synovium. The aims of this study were to determine chemokine receptor expression by B cells both in the peripheral blood of normal donors and subjects with RA, and at the inflammatory site in RA, and the effects of chemokines on B cell activation. 相似文献11.
Pernille Bøyesen Mari Hoff Sigrid Ødegård Glenn Haugeberg Silje W Syversen Per I Gaarder Cecilie Okkenhaug Tore K Kvien 《Arthritis research & therapy》2009,11(4):R103-9
Introduction
Radiographic progression in rheumatoid arthritis (RA) has in several studies been shown to be predicted by serological markers widely used in daily clinical practice. The objective of this longitudinal study was to examine if these serological markers also predict hand bone mineral density (BMD) loss in patients with RA of short disease duration. 相似文献12.
Maria Rehnberg Mikael Brisslert Sylvie Amu Kiandoht Zendjanchi Gunilla Håwi Maria I Bokarewa 《Arthritis research & therapy》2010,12(3):R111
Introduction
Rheumatoid arthritis (RA) is frequently complicated with infections. The aim of our study was to evaluate vaccination response in patients with RA after B-cell depletion by using rituximab. 相似文献13.
Seo Young Kim Sebastian Schneeweiss Jun Liu Gregory W Daniel Chun-Lan Chang Katie Garneau Daniel H Solomon 《Arthritis research & therapy》2010,12(4):R154
Introduction
Although osteoporosis has been reported to be more common in patients with rheumatoid arthritis (RA), little is known whether the risk of osteoporotic fractures in these patients differs by age, sex, and anatomic site. 相似文献14.
M Margarida Souto-Carneiro Vijayabhanu Mahadevan Kazuki Takada Ruth Fritsch-Stork Toshihiro Nanki Margaret Brown Thomas A Fleisher Mildred Wilson Raphaela Goldbach-Mansky Peter E Lipsky 《Arthritis research & therapy》2009,11(3):R84-12
Introduction
Disturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases, but have not been fully delineated in rheumatoid arthritis (RA). Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in RA is still unclear. 相似文献15.
Barnetche T Constantin A Cantagrel A Cambon-Thomsen A Gourraud PA 《Arthritis research & therapy》2008,10(1):R26
Introduction
Rheumatoid arthritis (RA) is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope (SE) (RAA amino acid pattern in positions 72 to 74 of the third hypervariable region of the DRβ1 chain) are associated with RA susceptibility. A new classification of HLA-DRB1 SE alleles has been developed by Tezenas du Montcel and colleagues to refine the association between HLA-DRB1 and RA. In the present study, we used RA samples collected worldwide to investigate the relevance of this new HLA-DRB1 classification in terms of RA susceptibility across various Caucasoid and non-Caucasoid patients. 相似文献16.
Vanina Jodon de Villeroché Jérome Avouac Aurélie Ponceau Barbara Ruiz André Kahan Catherine Boileau Georges Uzan Yannick Allanore 《Arthritis research & therapy》2010,12(1):R27
Introduction
Angiogenesis and vasculogenesis are critical in rheumatoid arthritis (RA) as they could be a key issue for chronic synovitis. Contradictory results have been published regarding circulating endothelial progenitor cells (EPCs) in RA. We herein investigated late outgrowth EPC sub-population using recent recommendations in patients with RA and healthy controls. 相似文献17.
Mohammed A Akhavani Leigh Madden Ian Buysschaert Branavan Sivakumar Norbert Kang Ewa M Paleolog 《Arthritis research & therapy》2009,11(3):R64
Introduction
Rheumatoid arthritis (RA) is characterised by invasion of cartilage, bone and tendon by inflamed synovium. Previous studies in our laboratory have shown that hypoxia is a feature of RA synovitis. In the present study, we investigated the consequences of hypoxia on angiogenesis and synovial fibroblast migration in RA. 相似文献18.
Eun Ha Kang Dong Jo Kim Eun Young Lee Yun Jong Lee Eun Bong Lee Yeong Wook Song 《Arthritis research & therapy》2009,11(4):R130-8
Introduction
Heat shock protein 70 (Hsp70) is a well-known anti-apoptotic protein that blocks multiple steps in the stress-induced apoptotic pathway. Enhanced Hsp70 expression has previously been demonstrated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). The authors investigated the role of Hsp70 in the survival of RA FLSs in a sodium nitroprusside (SNP)-treated environment. 相似文献19.
Kapetanovic MC Lindqvist E Algulin J Jonsson K Saxne T Eberhardt K Geborek P 《Arthritis research & therapy》2011,13(1):R31
Introduction
Changes in bone mineral density (BMD) in the hand as evaluated by digital X-ray radiogrammetry (DXR) of the second to fourth metacarpal bones has been suggested to predict future joint damage in patients with rheumatoid arthritis (RA). This study's objective was to investigate whether DXR-BMD loss early in the course of the disease predicts the development of joint damage in RA patients followed for up to 20 years. 相似文献20.
Nielsen KR Steffensen R Boegsted M Baech J Lundbye-Christensen S Hetland ML Krintel SB Johnsen HE Nyegaard M Johansen JS 《Arthritis research & therapy》2011,13(3):R109