共查询到20条相似文献,搜索用时 15 毫秒
1.
Michael Hackenberg Christopher Previti Pedro Luis Luque-Escamilla Pedro Carpena José Martínez-Aroza José L Oliver 《BMC bioinformatics》2006,7(1):446-13
Background
Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large parameter space formed by the thresholds of length, CpG fraction and G+C content. 相似文献2.
Background
Microarray is a high-throughput technology to study expression of thousands of genes in parallel. A critical aspect of microarray production is the design aimed at space optimization while maximizing the number of gene probes and their replicates to be spotted. 相似文献3.
Objective
A long-term, follow-up study comparing mild and severe forms of endometriosis and their fecundability, on 28 women diagnosed with endometriosis in adolescence. 相似文献4.
Background
Understanding the evolutionary relationships among species based on their genetic information is one of the primary objectives in phylogenetic analysis. Reconstructing phylogenies for large data sets is still a challenging task in Bioinformatics. 相似文献5.
Jun Nagano Chikage Kakuta Chikako Motomura Hiroshi Odajima Nobuyuki Sudo Sankei Nishima Chiharu Kubo 《BioPsychoSocial medicine》2010,4(1):12
Objective
To examine relationships between a mother's stress-related conditions and parenting attitudes and their children's asthmatic status. 相似文献6.
Ishimori ML Altman RD Cohen MJ Cui J Guo X Rotter JI Weisman MH 《Arthritis research & therapy》2010,12(5):R180
Introduction
The objective of the present study was to assess heritability of clinical and radiographic features of hand osteoarthritis (OA) in affected patients and their siblings. 相似文献7.
Background
Composition Profiler is a web-based tool for semi-automatic discovery of enrichment or depletion of amino acids, either individually or grouped by their physico-chemical or structural properties. 相似文献8.
Christopher Burton Hans Knoop Nikola Popovic Michael Sharpe Gijs Bleijenberg 《BioPsychoSocial medicine》2009,3(1):1-9
Objective
We examined developmental aspects of the emotional awareness of adolescents by evaluating their responses to a self-reported questionnaire based on the Toronto Alexithymia Scale-20 (TAS-20). 相似文献9.
Background
Techniques for measuring protein abundance are rapidly advancing and we are now in a situation where we anticipate many protein abundance data sets will be available in the near future. Since proteins are translated from mRNAs, their expression is expected to be related to their abundance, to some degree. 相似文献10.
Fabio Grizzi Antonio Di Ieva Carlo Russo Eldo E Frezza Everardo Cobos Pier Carlo Muzzio Maurizio Chiriva-Internati 《Theoretical biology & medical modelling》2006,3(1):37-6
Background
Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress through carcinogenesis and acquire their metastatic ability is still widely debated. 相似文献11.
Wenjie Shu Xiaochen Bo Rujia Liu Dongsheng Zhao Zhiqiang Zheng Shengqi Wang 《BMC bioinformatics》2006,7(1):404-7
Background
The diverse functions of ncRNAs critically depend on their structures. Mutations in ncRNAs disrupting the structures of functional sites are expected to be deleterious. RNA deleterious mutations have attracted wide attentions because some of them in cells result in serious disease, and some others in microbes influence their fitness. 相似文献12.
Background
Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics within their website. However, these approaches are limited in their use of data from multiallelic markers and provide limited information in a graphical form. 相似文献13.
Federico E Turkheimer Federico Roncaroli Benoit Hennuy Christian Herens Minh Nguyen Didier Martin Annick Evrard Vincent Bours Jacques Boniver Manuel Deprez 《BMC bioinformatics》2006,7(1):526
Background
Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. 相似文献14.
15.
Background
Microarray core facilities are commonplace in biological research organizations, and need systems for accurately tracking various logistical aspects of their operation. Although these different needs could be handled separately, an integrated management system provides benefits in organization, automation and reduction in errors. 相似文献16.
Background
With advances in high-throughput genomics and proteomics, it is challenging for biologists to deal with large data files and to map their data to annotations in public databases. 相似文献17.
Arunachalam Vinayagam Coral del Val Falk Schubert Roland Eils Karl-Heinz Glatting Sándor Suhai Rainer König 《BMC bioinformatics》2006,7(1):161-7
Background
Vast progress in sequencing projects has called for annotation on a large scale. A Number of methods have been developed to address this challenging task. These methods, however, either apply to specific subsets, or their predictions are not formalised, or they do not provide precise confidence values for their predictions. 相似文献18.
Peter S Klosterman Andrew V Uzilov Yuri R Bendaña Robert K Bradley Sharon Chao Carolin Kosiol Nick Goldman Ian Holmes 《BMC bioinformatics》2006,7(1):428-25
Background
Recent years have seen the emergence of genome annotation methods based on the phylo-grammar, a probabilistic model combining continuous-time Markov chains and stochastic grammars. Previously, phylo-grammars have required considerable effort to implement, limiting their adoption by computational biologists. 相似文献19.
V.F. Bondici J.R. Lawrence N.H. Khan J.E. Hill E. Yergeau G.M. Wolfaardt J. Warner D.R. Korber 《Journal of applied microbiology》2013,114(6):1671-1686
Aims
To describe the diversity and metabolic potential of microbial communities in uranium mine tailings characterized by high pH, high metal concentration and low permeability.Methods and Results
To assess microbial diversity and their potential to influence the geochemistry of uranium mine tailings using aerobic and anaerobic culture‐based methods, in conjunction with next generation sequencing and clone library sequencing targeting two universal bacterial markers (the 16S rRNA and cpn60 genes). Growth assays revealed that 69% of the 59 distinct culturable isolates evaluated were multiple‐metal resistant, with 15% exhibiting dual‐metal hypertolerance. There was a moderately positive correlation coefficient (R = 0·43, P < 0·05) between multiple‐metal resistance of the isolates and their enzyme expression profile. Of the isolates tested, 17 reduced amorphous iron, 22 reduced molybdate and seven oxidized arsenite. Based on next generation sequencing, tailings depth was shown to influence bacterial community composition, with the difference in the microbial diversity of the upper (0–20 m) and middle (20–40 m) tailings zones being highly significant (P < 0·01) from the lower zone (40–60 m) and the difference in diversity of the upper and middle tailings zone being significant (P < 0·05). Phylotypes closely related to well‐known sulfate‐reducing and iron‐reducing bacteria were identified with low abundance, yet relatively high diversity.Conclusions
The presence of a population of metabolically‐diverse, metal‐resistant micro‐organisms within the tailings environment, along with their demonstrated capacity for transforming metal elements, suggests that these organisms have the potential to influence the long‐term geochemistry of the tailings.Significance and Impact of the study
This study is the first investigation of the diversity and functional potential of micro‐organisms present in low permeability, high pH uranium mine tailings. 相似文献20.