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雌激素在心脑血管疾病中的抗炎作用及机制 总被引:1,自引:0,他引:1
大量研究表明,虽然多种因素参与心脑血管疾病的发生与发展,但慢性炎症是动脉粥样硬化等心脑血管疾病发生的关键因素.雌激素作为心脑血管保护剂,不仅具有调节血脂,扩张血管,抑制血管平滑肌细胞增殖等作用,而且还具有确切的抗炎效应,但其作用机制复杂多样.本文就雌激素在心脑血管疾病防治中的抗炎作用及其机制进行综述,为临床上雌激素的替代治疗提供参考. 相似文献
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血尿酸对2型糖尿病动脉粥样硬化的影响 总被引:1,自引:0,他引:1
2型糖尿病患者发生大血管并发症的主要病理基础为动脉粥样硬化,且发生早、进展快、预后差、死亡率高,其引发的心脑血管疾病是糖尿病患者致死致残的主要原因之一.血尿酸是动脉粥样硬化的危险因素,与代谢综合征的多种成分,如肥胖、血脂异常、糖尿病、高血压、冠心病、胰岛素抵抗等密切相关.本文阐述2型糖尿病患者动脉粥样硬化发生中血尿酸的作用机制. 相似文献
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动脉粥样硬化不稳定斑块的药物治疗进展 总被引:3,自引:1,他引:2
动脉粥样硬化(As)不稳定斑块也称易损斑块.不稳定斑块表面溃疡形成、破裂及继发血栓形成,是引起急性心脑血管事件的闹饕±砘?药物治疗对防治不稳定斑块破裂的发生,降低急性心脑血管事件的发病率具有重要意义.治疗不稳定斑块的药物主要有他汀、抗氧化荆等,其主要药理学机制是抗炎、抗氧化、调节细胞因子、抑制MMPs活性等作用.本文对不稳定斑块有治疗作用的药物研究与应用进展做一综述,为急性心脑血管事件的治疗提供理论依据及线索. 相似文献
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动脉粥样硬化(atherosclerosis, AS)是心脑血管疾病的共同病理基础,建立具有中医瘀毒证候特色的动脉粥样硬化动物模型及客观规范的评价体系是现代心脑血管疾病研究的重要内容,对中医药防治心脑血管疾病基础研发及药效机制评价具有重要意义。本文通过对动脉粥样硬化瘀毒证的动物模型构建及评价进行了多方面的总结和归纳,同时分析了当前模型构建及评价存在的问题,以期为建立规范化的动物模型提供参考。 相似文献
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In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980. 相似文献
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N. P. Vesselkin Yu. V. Natochin 《Journal of Evolutionary Biochemistry and Physiology》2010,46(6):592-603
Evolution of living organisms is closely connected with evolution of structure of the system of regulations and its mechanisms.
The functional ground of regulations is chemical signalization. As early as in unicellular organisms there is a set of signal
mechanisms providing their life activity and orientation in space and time. Subsequent evolution of ways of chemical signalization
followed the way of development of delivery pathways of chemical signal and development of mechanisms of its regulation. The
mechanism of chemical regulation of the signal interaction is discussed by the example of the specialized system of transduction
of signal from neuron to neuron, of effect of hormone on the epithelial cell and modulation of this effect. These mechanisms
are considered as the most important ways of the fine and precise adaptation of chemical signalization underlying functioning
of physiological systems and organs of the living organism 相似文献