Highlights? ATP4 is required during gastrulation/neurulation for cilia-driven leftward flow to occur ? ATP4 acts on canonical and noncanonical Wnt signaling ? Wnt/β-catenin is necessary and sufficient for gastrula Foxj1 expression ? Leftward flow is the conserved mode of symmetry breakage in Xenopus相似文献
Highlights? mVam2 mediates endocytic transport from late endosomes to lysosomes ? mVam2 is essential for assembly of large apical vacuoles in visceral endoderm ? Loss of mVam2 results in hyperactivation of BMP signaling ? The mVam2-dependent BMP attenuation contributes to patterning in gastrulation 相似文献
Highlights? The peroxiredoxin, Jafrac1, controls primordial germ cell adhesion during gastrulation ? H2O2 treatment of Drosophila embryos reduces DE-cadherin and β-catenin levels ? Increasing DE-cadherin levels is sufficient to rescue the Jafrac1 phenotype ? Jafrac1 stabilizes the level of adherens junction components in Drosophila embryos 相似文献
Highlights? Upon infection, L. pneumophila secretes RomA, a SET domain-containing methyltransferase ? RomA triggers H3K14 trimethylation, causing a switch from gene activation to repression ? ChIP-seq identified 4,870 H3K14 methylated promoter regions, including innate immune genes ? RomA SET domain is required for efficient intracellular replication of L. pneumophila相似文献
Highlights? Wnt2 is required for atrial and inflow tract morphogenesis ? Wnt2 regulates expansion of secondary heart field progenitors ? Defects in Wnt2?/? mutants can be rescued using Wnt signaling agonists ? Wnt2 cooperates with Gata6 to regulate cardiac inflow tract development 相似文献
Highlights? ASH2L WH motif is important for trans-regulation of H3 K4 methylation by H2Bub ? Ub stimulates MLL activity in trans, in contrast to DOT1L regulation by H2Bub ? H2Bub enhances MLL, but not MLL3, methyltransferase activity ? H2Aub directly represses MLL methyltransferase activity 相似文献
Highlights? H2B ubiquitylation directly stimulates H3K4 methylation by the yeast Set1 complex ? Swd2 is not directly required for the H3K4 methylation activity of the yeast Set1 complex ? The Set1 n-SET domain plays a critical role in H2Bub-dependent H3K4 methylation ? Spp1 is conditionally involved in n-SET- and H2Bub-dependent H3K4 methylation 相似文献
Highlights? Fbxl10 binds to most CpG islands in ESCs ? Fbxl10 recruits Nspc1 and Ring1B to CpG islands ? The Fbxl10, Nspc1, and Ring1B complex is required for H2A monoubiquitylation ? Fbxl10 is required for proper ESC differentiation 相似文献
Highlights? Snx3 is highly expressed in vertebrate hematopoietic tissues ? Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates ? Snx3 and Vps35 physically interact with Tfrc ? Snx3 is required for endosomal recycling of Tf-Tfrc complex 相似文献
Highlights? H. pylori is highly susceptible to the bactericidal activity of hBD3 ? hBD3 is initially induced by H. pylori via activation of EGFR/MAPK/JAK signaling ? H. pylori evades killing by downregulating hBD3 via CagA-mediated SHP-2 activation ? CagA virulence factor is a potent inhibitor of an immune effector mechanism 相似文献
Highlights? Trachea-derived Dpp/Bmp is required for midgut homeostasis ? Dpp expressed in tracheal cells reach intestinal cells through visceral muscles ? Dpp signaling is activated in enterocytes (ECs) in the Drosophila adult midgut ? Dpp signaling stabilizes ECs to restrict intestinal stem cell proliferation 相似文献
Highlights? PP2A phosphatase is essential for centriole formation in C. elegans ? PP2A subunits genetically and physically interact with the SAS-5/SAS-6 complex ? PP2A-mediated dephosphorylation of SAS-5 is required for SAS-5/SAS-6 centriolar targeting ? Human PP2A is required for HsSAS-6 centriolar targeting and centriole formation 相似文献
Highlights? bantam is required in ecdysone-producing cells to promote body growth ? bantam inhibits ecdysone biosynthesis ? Insulin signaling regulates ecdysone production by repressing bantam activity ? Both the systemic and tissue-autonomous activities of bantam promote organ growth 相似文献
Highlights? mir92a inactivation leads to loss of pharyngeal cartilages in zebrafish embryos ? mir92a is required for chondrogenic progenitor proliferation and survival ? Bmp signaling is positively regulated by mir92a in the pharyngeal region ? nog3 mRNA is degraded by mir92a to maintain Bmp activity 相似文献
Highlights? Protein lysate arrays are a useful tool for the study of host–pathogen interactions ? Hepatocyte signaling is substantially perturbed in response to Plasmodium infection ? Regulation of host p53 is required for efficient Plasmodium development ? Elevated levels of p53 eliminate Plasmodium parasites during the liver stage 相似文献
Highlights? Larval multidendritic neurons are required for sensing gentle touch in Drosophila ? Optogenetic activation of defined multidendritic neurons triggers touch behaviors ? Sensory filopodia are dynamic, F-actin-rich organelles necessary for mechanosensing ? A high-throughput touch screen identifies NMDARs, NOMPC, and Ripped Pocket 相似文献
