Idoxifene对人乳内动脉的舒张作用

为了研究idoxifene(吲哚昔酚,一种新型雌激素受体调节剂)对人乳内动脉(human internal mammarya artery,HIMA)的舒张作用及其机制,采用离体血管灌流的方法,观察idoxifene对完整内皮和去内皮HIMA的舒张作用,以及L-NAME和美蓝(metllylene blue,MB)对这一过程的影响,并且和17β雌二醇(17β-estradiol,E2)的舒血管作用进行了比较。实验中观察到保留血管内皮时idoxifenc(0．01～10μmol／L)和E2(0．1～100μmol／I,)可以剂量依赖性地舒张血管,且血管对idoxifene的灵敏度比对E2高15倍左右,而去内皮时则无此作用;NO合成酶阻断剂L-NAME和鸟苷酸环化酶(guanylate cyclasc,GC)的抑制剂MB使idoxifene舒张HIMA的作用完全消失。上述结果表明：idoxifene能够剂量依赖性地舒张HIMA,而且比E2更有效。idoxifene的这种作用是通过NO-GC-cGMP通路实现的。     

Transient pseudohypoaldosteronism with complex malformation of internal genitalia. A case report

At the age of 3 weeks, a girl presenting with acute dehydration was admitted to our hospital. Clinical and laboratory findings revealed malformations of the genitourinary tract, an acute urinary infection and electrolyte disturbances (severe hyponatremia at 115 mmol/l and mild hyperkalemia at 5.6 mmol/l). According to anamnestic data, the child was born to healthy, nonconsanguineous parents. Vaccum extraction was done in the 38th gestational week due to pathological cardiotocography (CTG) findings. Auxological parameters were within the normal range for gestational age. Normal values for 17-OH progesterone and ACTH ruled out congenital adrenal hyperplasia (CAH). Pathologically high aldosterone and plasma renin activity (PRA) confirmed the diagnosis of pseudohypoaldosteronism with salt-wasting crisis which proved to be transient.