共查询到20条相似文献,搜索用时 31 毫秒
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Telomere and telomerase in oncology 总被引:10,自引:0,他引:10
MuJ WeiLX 《Cell research》2002,12(1):1-7
Telomere and cell replicative senescenceTelomeres, which are located at the end of chro-mosome, are crucial to protect chromosome againstdegeneration, rearrangment and end to end fusion[1].Human telomeres are tandemly repeated units of thehexanucleotide TTAGGG. The estimated length oftelomeric DNA varies from 2 to 20 kilo base pairs,depending on factors such as tissue type and hu-man age. The buck of telomeric DNA is double-stranded, but the end of telomeric DNA consists of3' overhang of… 相似文献
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Telomerase maintains telomere structure in normal human cells 总被引:68,自引:0,他引:68
Masutomi K Yu EY Khurts S Ben-Porath I Currier JL Metz GB Brooks MW Kaneko S Murakami S DeCaprio JA Weinberg RA Stewart SA Hahn WC 《Cell》2003,114(2):241-253
In normal human cells, telomeres shorten with successive rounds of cell division, and immortalization correlates with stabilization of telomere length. These observations suggest that human cancer cells achieve immortalization in large part through the illegitimate activation of telomerase expression. Here, we demonstrate that the rate-limiting telomerase catalytic subunit hTERT is expressed in cycling primary presenescent human fibroblasts, previously believed to lack hTERT expression and telomerase activity. Disruption of telomerase activity in normal human cells slows cell proliferation, restricts cell lifespan, and alters the maintenance of the 3' single-stranded telomeric overhang without changing the rate of overall telomere shortening. Together, these observations support the view that telomerase and telomere structure are dynamically regulated in normal human cells and that telomere length alone is unlikely to trigger entry into replicative senescence. 相似文献
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端粒及端粒酶的研究进展 总被引:13,自引:0,他引:13
端粒是染色体末端独特的蛋白质-DNA结构,在保护染色体的完整性和维持细胞的复制能力方面起着重要的作用.端粒酶则是由RNA和蛋白质亚基组成的、能够延长端粒的一种特殊反转录酶.端粒长度和端粒酶活性的变化与细胞衰老和癌变密切相关.端粒结合蛋白可能通过调节端粒酶的活性来调节端粒长度,进而控制细胞的衰老、永生化和癌变.研制端粒酶的专一性抑制剂在肿瘤治疗方面有着广阔的前景. 相似文献
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Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro. 总被引:4,自引:0,他引:4
N Hayakawa K Nozawa A Ogawa N Kato K Yoshida K i Akamatsu M Tsuchiya A Nagasaka S Yoshida 《Biochemistry》1999,38(35):11501-11507
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Inhibition of telomerase limits the growth of human cancer cells. 总被引:43,自引:0,他引:43
W C Hahn S A Stewart M W Brooks S G York E Eaton A Kurachi R L Beijersbergen J H Knoll M Meyerson R A Weinberg 《Nature medicine》1999,5(10):1164-1170
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Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis 总被引:2,自引:0,他引:2
Biroccio A Amodei S Antonelli A Benassi B Zupi G 《The Journal of biological chemistry》2003,278(37):35693-35701
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Xiong J Fan S Meng Q Schramm L Wang C Bouzahza B Zhou J Zafonte B Goldberg ID Haddad BR Pestell RG Rosen EM 《Molecular and cellular biology》2003,23(23):8668-8690
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Human telomerase and its regulation. 总被引:38,自引:0,他引:38
Yu-Sheng Cong Woodring E Wright Jerry W Shay 《Microbiology and molecular biology reviews》2002,66(3):407-25, table of contents
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