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RNA editing in kinetoplastid protozoa. 总被引:1,自引:0,他引:1
K Stuart 《Current opinion in genetics & development》1991,1(3):412-416
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Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity
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Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make a stable mRNA. This alternatively edited mRNA is translated to produce a unique protein that fractionates with mitochondrial membranes and colocalizes with mitochondrial proteins in situ. Alternative RNA editing represents a previously unknown mechanism generating protein diversity and, as such, represents an important function for RNA editing. 相似文献
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RNA editing site recognition in higher plant mitochondria. 总被引:4,自引:0,他引:4
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Mitochondrial DNA of an African trypanosome 总被引:9,自引:0,他引:9
K Stuart 《Journal of cellular biochemistry》1983,23(1-4):13-26
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