Embryology and evolution 1920-1960: worlds apart?

During the early part of the 20th century most embryologists were skeptical about the significance of Mendelian genetics to embryological development. A few embryologists began to study the developmental effects of Mendelian genes around 1940. Such work was a necessary step on the path to modern developmental biology. It occurred during the time when the Evolutionary Synthesis was integrating Mendelian and population genetics into a unified evolutionary theory. Why did the first embryological geneticists begin their study at that particular time? One possible explanation is that developmental genetics was a potential avenue of alliance between embryology and evolutionary biology, two fields that had been separated since the 1890s. To assess this possible motive it is necessary to explore the methodological contrasts that obtained between embryology and both Mendelian-chromosomal genetics and neo-Darwinian evolutionary theory. Some of these contrasts persist to the present day.     

遗传学史在遗传学教学中的作用

科学史的研究和发展状况能反映一个国家的科学技术水平,遗传学史是生命科学发展史的一个重要分支,21世纪是生命科学的世纪,在遗传学教学中加强遗传学发展史的介绍,不仅具有教育功能,使学生了解遗传学的产生和发展,而且可以培养学生的思维能力和科学素质。本文就遗传学史的教育功能及在教学中的作用进行论述。     

Australian genetics: A brief history

Although Australia has a productive history in plant and animal breeding, fundamental genetics was late in becoming established. Before the 1950s there was no separate department of genetics in any university in the country. Reasons for the delay include geographical isolation, Australian and British colonial science policy, and the lack of a critical mass of researchers. Through the efforts of Ian Clunies Ross and the CSIR several prominent scientists were induced to come from overseas to set up the framework for an Australian-based genetics community. Since that time fundamental genetics in Australia has flourished with high quality graduates in genetics being produced at a number of universities, and many local research programs being initiated. This period has seen the gradual internationalisation of Australian genetics and increased collaboration with overseas researchers taking place. This paper provides an historical overview of the origins and progress of genetics in Australia beginning with plant breeding in the first decades of this century to the present era of molecular genetics. Significant personalities, institutions, policies, reports and publications are discussed in order to make sense of the current structures.     

Mice and the Reactor: The “Genetics Experiment” in 1950s Britain

The postwar investments by several governments into the development of atomic energy for military and peaceful uses fuelled the fears not only of the exposure to acute doses of radiation as could be expected from nuclear accidents or atomic warfare but also of the long-term effects of low-dose exposure to radiation. Following similar studies pursued under the aegis of the Manhattan Project in the United States, the “genetics experiment” discussed by scientists and government officials in Britain soon after the war, consisted in large-scale low-dose irradiation experiments of laboratory animals to assess the effects of such exposures on humans. The essay deals with the history of that project and its impact on postwar genetics. It argues that radiobiological concerns driven by atomic politics lay at the heart of much genetics research after the war and that the atomic links are crucial to understand how genetics became an overriding concern in the late 20th century.     

Abbey ambitions to celebrate home of genetics

A century and a half after the ground-breaking work by Gregor Mendel in establishing the foundation of genetics, efforts are under way to develop a fitting commemoration of his work at his abbey home in Brno. Nigel Williams reports.     

Introduction and Institutionalization of Genetics in Mexico Ana Barahona,Susana Pinar and Francisco J. Ayala

We explore the distinctive characteristics of Mexico’s society, politics and history that impacted the establishment of genetics in Mexico, as a new disciplinary field that began in the early 20th century and was consolidated and institutionalized in the second half. We identify about three stages in the institutionalization of genetics in Mexico. The first stage can be characterized by Edmundo Taboada, who was the leader of a research program initiated during the Cárdenas government (1934–1940), which was primarily directed towards improving the condition of small Mexican farmers. Taboada is the first Mexican post-graduate investigator in phytotechnology and phytopathology, trained at Cornell University and the University of Minnesota, in 1932 and 1933, respectively. He was the first investigator to teach plant genetics at the National School of Agriculture and wrote the first textbook of general genetics, Genetics Notes, in 1938. Taboada’s most important single genetics contribution was the production of “stabilized” corn varieties. The extensive exile of Spanish intellectuals to Mexico, after the end of Spain’s Civil War (1936–1939), had a major influence in Mexican science and characterizes the second stage. The three main personalities contributing to Mexican genetics are Federico Bonet de Marco and Bibiano Fernández Osorio Tafall, at the National School of Biological Sciences, and José Luis de la Loma y Oteyza, at the Chapingo Agriculture School. The main contribution of the Spanish exiles to the introduction of genetics in Mexico concerned teaching. They introduced in several universities genetics as a distinctive discipline within the biology curriculum and wrote genetics text books and manuals. The third stage is identified with Alfonso León de Garay, who founded the Genetics and Radiobiology Program in 1960 within the National Commission of Nuclear Energy, which had been founded in 1956. The Genetics and Radiobiology Program rapidly became a disciplinary program, for it embraced research, teaching, and training of academics and technicians. The Mexican Genetics Society, created by de Garay in 1966, and the development of strains and cultures for genetics research were important activities. One of de Garay’s key requirements was the compulsory training of the Program’s scientists for at least one or two years in the best universities of the United States and Europe. De Garay’s role in the development of Mexican genetics was fundamental. His broad vision encompassed the practice of genetics in all its manifestations.     

Engineering American society: the lesson of eugenics

We stand at the threshold of a new century, with the whole human genome stretched out before us. Messages from science, the popular media, and the stock market suggest a world of seemingly limitless opportunities to improve human health and productivity. But at the turn of the last century, science and society faced a similar rush to exploit human genetics. The story of eugenics--humankind's first venture into a 'gene age'--holds a cautionary lesson for our current preoccupation with genes.     

Understanding human DNA sequence variation

Over the past century researchers have identified normal genetic variation and studied that variation in diverse human populations to determine the amounts and distributions of that variation. That information is being used to develop an understanding of the demographic histories of the different populations and the species as a whole, among other studies. With the advent of DNA-based markers in the last quarter century, these studies have accelerated. One of the challenges for the next century is to understand that variation. One component of that understanding will be population genetics. We present here examples of many of the ways these new data can be analyzed from a population perspective using results from our laboratory on multiple individual DNA-based polymorphisms, many clustered in haplotypes, studied in multiple populations representing all major geographic regions of the world. These data support an "out of Africa" hypothesis for human dispersal around the world and begin to refine the understanding of population structures and genetic relationships. We are also developing baseline information against which we can compare findings at different loci to aid in the identification of loci subject, now and in the past, to selection (directional or balancing). We do not yet have a comprehensive understanding of the extensive variation in the human genome, but some of that understanding is coming from population genetics.     

走向21世纪的遗传学

对一个世纪以来遗传学的发展史及其所取得的主要成就作了回顾,并对二十一世纪遗传学的发展趋势进行了展望。     

国内高校遗传学教材发展研究

教材建设是课程建设的重要环节。遗传学教学在中国的发展道路是崎岖曲折的, 与生命科学其他学科相比有其独特之处。通过对国内遗传学教材从解放前到21世纪的发展历程的研究, 希望能为组编出更符合大学本科生教学特点, 贴近国内外遗传学发展前沿的教材, 培养具有遗传学基本知识和创新能力的应用和研究型人才提供有价值的参考。     

Trends in genetics--before the molecular era

Molecular techniques and biochemical questions came to dominate genetic research during the later half of the 1900th century. This does not mean that earlier achievements have lost their importance. In this review the trends in classic genetics are followed from the beginning in 1900 until the molecular aspects took over, and it is shown how they form the basis for many trains of thought in present day genetics.     

James Cossar Ewart and the Origins of the Animal Breeding Research Department in Edinburgh, 1895–1920

In 1919 the Animal Breeding Research Department was established in Edinburgh. This Department, later renamed the Institute of Animal Genetics, forged an international reputation, eventually becoming the centrepiece of a cluster of new genetics research units and institutions in Edinburgh after the Second World War. Yet despite its significance for institutionalising animal genetics research in the UK, the origins and development of the Department have not received as much scholarly attention as its importance warrants. This paper sheds new light on Edinburgh’s place in early British genetics by drawing upon recently catalogued archival sources including the papers of James Cossar Ewart, Regius Professor of Natural History at the University of Edinburgh between 1882 and 1927. Although presently a marginal figure in genetics historiography, Ewart established two sites for experimental animal breeding work between 1895 and 1911 and played a central role in the founding of Britain’s first genetics lectureship, also in 1911. These early efforts helped to secure government funding in 1913. However, a combination of the First World War, bureaucratic problems and Ewart’s personal ambitions delayed the creation of the Department and the appointment of its director by another six years. This paper charts the institutionalisation of animal breeding and genetics research in Edinburgh within the wider contexts of British genetics and agriculture in the early twentieth century.     

Contributions and promise of human behavioral genetics

Human behavioral genetics has contributed greatly to our understanding of human behavioral development. Twin, family, and adoption studies have shown that genetic effects are ubiquitous and that both genes and environments contribute to individual differences in behavior. The unique ability of behavioral genetic methods to separate genetic from environmental effects has also led to important discoveries about how the environment works in development and to the elucidation of the complex ways environments and genes interact across the life span. Although quantitative methods have been the mainstay of the field of human behavioral genetics since Galton's time, the Human Genome Project and advances in molecular genetics are providing new tools and promise as we enter the 21st century. Thus the future of human behavioral genetics lies in the cross-disciplinary exchanges and collaborations that will increasingly occur in the years to come among quantitative and molecular scientists who work with both animal and human systems. This research may someday culminate in an understanding of the biological basis of behavior that spans from how the brain develops and functions to a grasp of how genes influence thought at the molecular level.     

Theory and practice: the impact of Mendelism on agriculture

The purpose of this paper is a reexamination of the success story of how Mendelian genetics gave birth to a revolution in plant and animal breeding which produced the spectacular 20th century agricultural progress and made it possible to feed the exploding population of the Earth. Critics have pointed to the problematic social effect of the agricultural revolution, and they have doubted the importance of the new genetics, especially during the first three or four decades of the 20th century. This paper argues that the criticism has tended to take a narrow instrumental view of science underestimating the guiding role of theory in practical matters. Plant and animal breeding continued to depend mainly on the old 19th century techniques, hybridization, mass selection and individual selection. But they were combined and used in much more efficient ways than before. New theoretical knowledge, general theories as well as particular knowledge about species, strains and individuals, radically improved the planning and execution of breeding work.     

Genetic Predictors of Susceptibility to Dermatophytoses

Countless observational studies conducted over the last century reveal that dermatophytes infect humans of every age, race, gender, and socioeconomic status with strikingly high rates. The curious disparity in dermatophyte infection patterns observed within and between populations has led countless investigators to explore whether genetics underlie a susceptibility to, or confer protection against, dermatophyte infections. This paper examines the data that offer a link between genetics and dermatophytoses and discusses the underlying mechanisms that support these observations.     

Ira

For a quarter of a century in genetics if you said Ira the chances were you meant Ira Herskowitz. When he died, on April 28 this year, it left a hole in the fields of genetics and genomics the size of the Grand Canyon.     

Research note: Genes on chromosomes: The conversion of Thomas Hunt Morgan

In the first decade of the twentieth century, the foundation for the science of genetics was set. In 1900, the data of Gregor Mendel were rediscovered. By 1915, a community of scientists accepted that there were entities on chromosomes that controlled the development of observable traits. During the intervening period, Thomas Hunt Morgan was one of the major skeptics regarding the chromosomal location of the genes. His acceptance may have been the turning point for the flowering of American genetics. This paper will discuss the reasons for Morgan's recalcitrance, his conversion to belief, and the nature of the scientific evidence that led to his acceptance.     

A century of biometrical genetics

We briefly review the major contribution of biometrics to genetics over the last century (population genetic models, familial correlations, segregation analysis, and gene mapping) and current areas of active research and then speculate about what problems will be tackled in the next century.     

医学病例在高校普通遗传学教学中的运用

遗传学是生命科学、医学、农学等相关领域的核心课程。作为21世纪生命科学中发展最为迅速的学科之一,教学内容复杂、更新快,遗传学知识对人一生的影响也日益增强,特别是与医学相关的遗传学知识更是受到大众关注。为使学生更容易理解深奥的遗传学知识,使教学内容更贴近生活,在教学过程中引入医学病例,将相应的医学病例同遗传学理论知识结合并作出适当的延伸,将有利于提高学生的遗传学知识综合分析能力,同时提高学生的学习积极性和实用技能。本文根据现代遗传学教学体系,引入相应的医学病例,强调培养学生综合遗传分析能力,为综合性大学、师范院校的普通遗传学教学提供参考。