Le rôle des exploitations minières de la région d’Autun dans la constitution des collections paléontologiques

The birth of the oil shale industry, in the Autun basin (Saône-et-Loire, department in Burgundy), at the beginning of the 1830s, corresponded to a time during which the scientific progress in geology and paleontology was quite fast-paced. The development of the schist industry happened at a time when landmark works were published such as those by Louis Agassiz or Adolphe Brongniart. These scientists relied upon the on-going findings in the Autunois area. An outstanding dynamics was on its way. It brought about the updating of many samples sparking off important paleontological studies. A remarkable coordination set up between the industrial workers of the schist industry, the local scholars on the one hand and the National Museum of Natural History in Paris on the other hand. There resulted from it a frequent if not constant interest in the discovery of the fossils that the layers of schists – exploited with the aim of obtaining oil used as a quaffing product – can contain. This dynamics kept going on till the beginning of the 19th century. It was carried out by outstanding personalities such as Bernard Renault or Auguste Roche who were at the origin of the first collections gathered by the Society of Natural History in Autun, founded in 1886. But then, the findings were made rare. The mechanization of the chopping down and crushing of the schist did not any more offer the suitable conditions to discover new specimens. Anyway, the accumulated collections are already considerable and make of the Autunois one of the major places of great French paleontological progress in the years 1870 and 1880.     

Rôle du gypaète barbu (Gypaetus barbatus) dans la constitution de l’assemblage osseux de la grotte du Noisetier (Fréchet-Aure,Hautes-Pyrénées,France)

Located in the Aure Valley (French central Pyrénées), the Noisetier cave opens at 825 m asl. This Middle Palaeolithic site has produced a Mousterian industry associated with a rich faunal assemblage. Bone remains are dominated by Chamois then Ibex and Red deer. Taphonomic analysis strongly suggests a human origin for the Ibex and the Red deer but questions arise for the Chamois. The chamois assemblage differed from the bones of both species by its low cut marks ratio. Semi-digested bones are particularly abundant. Differences are even more perceptible for skeletal portions. For Red deer and Ibex, long bone remains are mostly shaft portions whereas for Chamois, ends are the most abundant. Comparisons of the Noisetier cave bone assemblage with different present-day reference data leads to the conclusion that Chamois bones have mostly been accumulated by bearded vultures.     

La stratigraphie et le Paléolithique du complexe saalien dans la région de la Saale et de l’Elbe

Some sediment sequences were known in the Elbe-Saale region. They enable a subdivision of the Saale complex, that is from Neumark Nord (Geisel valley), from Weimar-Ehringsdorf and Bad Kösen-Lengefeld (Saale valley). According to it, there are two interglacials between the Saalian groundmoraine (s.str.) and the Eemian. They are characterized by a strong subcontinental climatic influence, which could not be observed in the other interglacials of the Elbe-Saale region. The interglacials are connected with find horizons from the Middle Palaeolithic. They are concisely described here with their inventories.     

Apport de deux techniques d’analyse automatisées des examens [F] FDG TEP dans la discrimination des patients déments frontotemporaux et malades d’Alzheimer

Introduction

In younger patients, the in vivo clinical diagnosis of Alzheimer's disease (AD) and of the frontotemporal type (FTD) may be cumbersome. The gold standard diagnostic proof is currently still based upon pathology examination. It is crucial to find reliable techniques to make an accurate in vivo diagnosis and to differentiate the etiology of the dementia.

Patients and method

Twenty-four patients bearing clinically diagnosed AD (n = 16) and FTD (n = 8) underwent [¹⁸F] FDG-PET/CT brain scan. Four nuclear medicine physicians with varying expertise in neuroimaging read each scan according to: visual analysis; automated analysis computed by BRASS^® Hermes^® software; automated analysis computed by Cortex ID^® General Electric^® software. Interpretation aimed at assessing the global scan aspect, the cerebral metabolism per hemisphere (in five relevant regions) and the diagnostic degree of confidence. Diagnostic interpretations derived from visual and automated analyses were compared to clinical diagnosis. Inter-observer agreement and Kappa scores were calculated.

Results

Kappa analyses showed a gain in diagnostic accuracy for a nonexpert physician, a gain in diagnostic confidence with Cortex ID^® and a gain in interobserver diagnostic agreement with BRASS^®.

Conclusion

Using automated software such as Cortex ID^® or BRASS^® helps standardizing the interpretation of [¹⁸F] FDG distribution pattern in AD or FTD.     

Apport de l’imagerie hybride TEMP-TDM dans le suivi d’un cancer différencié de la thyroïde

In the management of patients with differentiated thyroid cancer (DTC), abnormalities detected on planar whole body scan and ¹³¹I-SPECT are difficult to interpret because of a lack of anatomical landmarks and limited specificity. Integrated ¹³¹I-SPECT-CT imaging has an additional value for characterization of equivocal tracer uptake seen on planar imaging as well as for precise localization. We illustrate through an observation the incremental diagnostic value of ¹³¹I-SPECT-CT images in the diagnosis of a cervical lymph node mimicking a physiological uptake on planar views. A 35-year-old Tunisian female was followed for papillary thyroid carcinoma, for which she underwent total thyroidectomy and iratherapy. Three years after a complete remission, the thyroglobulin (Tg) level on TSH stimulation increased. Diagnostic planar images with ¹³¹I did not disclose any obvious pathological foci. Furthermore, we noticed an increased ¹³¹I-uptake in the left sub-mandibulary area, which suggested a salivary physiological activity. SPECT-CT of the neck and chest were then performed with a Symbia T camera. Fused images demonstrate that this activity corresponds to a cervical lymph node closely adjacent to sub-mandibulary gland. Management of the patient was then changed. In selected patients with DTC, hybrid imaging should be used as a complementary to planar imaging in terms of diagnostic accuracy, because of superior focus localization and additional anatomic information derived from the CT component. Integrated SPECT-CT is then a useful tool, especially in cases of unclear diagnoses, precising anatomical localization of areas of increased ¹³¹I-uptake and distinguishing malignant lesions from normal physiological uptakes. This is particularly important in an oncologic center, as ours, where we don’t yet have a positron emission tomography (PET) camera is not yet available.     

Le Paléolithique moyen et supérieur de la Hongrie du nord : nouvelles investigations dans la région d’Eger

The region of Eger town at the foot of the Bükk Mountains in Northeastern Hungary has particular importance for the understanding the Middle and Upper Palaeolithic periods of the Carpathian Basin. One of the key-problems is the association of carinated tools and foliate points in the lithic assemblages of the sites. New investigations at the Egerszalók-K?vágó site give fundamental data for the animated discussion on the relation between Aurignacian and Szeletian.     

Sols et structures d’habitat du Paléolithique supérieur, nouvelles données depuis les Cantabres : la Galerie Inférieure de La Garma (Cantabrie, Espagne)

A brief review is done of the history of the research on Upper Paleolithic floors and structures, with a general outline of the main substantive and theoretical-methodological aspects. On the resulting “state of the art” we present the preliminary results of the study of the occupation evidences from the Lower Gallery of La Garma. In essence, it constitutes an astonishing ensemble of extensive Middle Magdalenian occupation floors, exceptionally rich and quite well preserved, including several structures and associated with rock art paintings and carvings of that period. The potential of the site is superlative, and the research’s project already begins to offer some interesting results of which this article is a fairly small advance.     

Influence de l'intensité et de la longueur d'onde de la lumière sur le rendement des radicaux libres dans les semences de tomate et de carotte

Influence of light intensity and wavelength on the yield of free radicals in seeds of tomato and carrot.
Seeds of tomato ( Lycopersicum esculentum L. cv. Gribovsky-1180) and carrot ( Daucus carota L. cv. Santanet) were irradiated by continuous light of different wavelengths (white, blue, green, red, far-red and He-Ne laser) and different power density. Free radical output was measured using Electron Spin Resonance spectra (ESR). The dependence of the content of free radicals (FR) on the light power density was established. The yield of FR in the seeds irradiated with monochromatic light of the same power density was inversely proportional to the wavelength. The ESR spectra showed maximum absolute number of FR for white light. Successive irradiations gave cumulative effects on the output of free radicals in both directions: increase by the action of white light and decrease by the action of red and far-red light. The contact of irradiated seeds with steam decreased the amount of FR.     

L’habitat en grotte au Néolithique : vers une estimation de l’intensité des occupations

The archaeological excavation of the cave of the Gardon has brought to light a dilated and nearly continuous stratigraphy for the Neolithic era. The analysis of lithic industry has showed the existence of variations between those neolithic layers, which are independents of the technological processes of tools productions. Four criteria allow us to characterize the occupation’s type of each layer. Compared to the excavations data and to sedimentological analysis, these results allow us to display the evolution of the intensity of occupations of the cave throughout the whole Neolithic.     

L’étude des conditions d’habitabilité des établissements préhistoriques : à propos des amas coquilliers mésolithiques de la région cantabrique occidentale (Nord de l’Espagne)

We show the methodology we followed in order to reliably estimate a factor that, to our judgement, is fundamental for the assessment of the characteristics of a prehistoric settlement: the conditions of exposure to the sun. This methodology is applied to the study of Mesolithic shell middens in the North of Spain, with the aim to introduce a new kind of information in the debate about the meaning of shell middens. Throughout this century, different ways to understand the behaviour these remains conceal have been proposed. Our thesis with regard to it, presented in this paper, is based on the observation of a series of variables, among which we can find the exposure to the sun the settlements undergo. We therefore show in the last part of the paper, how to join the information from the proposed analysis with the other data subsequent from the study of other variables such as the environmental conditions prevailing during the period of formation of the sites; the situation of the settlements; the location of the remains in the caves; the entity of the occupations; and the energy spent on the transportation of the aquatic resources from the coast towards the places where their rests are found nowadays. In short, we propound a methodology for the study of one of the variables that falls upon the habitability of a prehistoric settlement and we point out the contribution that the incorporation of an analysis of this kind means for the research of Mesolithic shell middens in the North of Spain.     

L’imagerie TEP-traceurs des plaques amyloïdes : le point de vue du clinicien

The purpose of this article is to summarize the main elements of clinician point of view concerning the contribution of amyloid neuroimaging in the diagnostic approach of the Alzheimer's disease. The main pathological characteristics of the Alzheimer's disease are established by two types of protein aggregates: the extracellular plaques (containing Aβ aggregates) and neurofibrillary tangles (composed of aggregates of tau-protein). At present, the use of biomarkers is more and more included in the diagnostic approach of Alzheimer's disease. The possibility to highlight in vivo cortical amyloid deposits through the amyloid neuroimaging can allow the realization of an earlier diagnosis. However, the amyloid imaging is a “physiopathological” biomarker and is not correlated with the clinical evaluation. It is still difficult to differentiate the Alzheimer's disease of the other neurodegenerative diseases.     

La Lloseta : une grotte importante et presque méconnue dans l'ensemble de Ardines, Ribadesella

This summary on The Lloseta shows us a much richer reality that it had been presented through the precedent publications. To begin it is presented as an shelter environment decorated in all their extension whose decoration and parallel they find real sense if we put them in connection with the neigh boring Tito Bustillo. It possesses a prevalence of signs and old representations, a bad general conservation and an own and original internal organization. None of the caves of Ardines, including their main protagonist, she makes isolated significant sense, but rather they are and were supplemented in the past, for activities, occupation and use. We try to know the meaning of all and each one of the caves in connection with the other ones, because we think that their function should be collective and complementary.     

Néandertal et le feu au Paléolithique moyen ancien. Tour d’horizon des traces de son utilisation dans le Nord de la France

This article aims at drawing up balance sheet of remains of fire use by the first Neanderthals of Northern France, during the second part of the Saalian (MIS 8 to 6). This overview reminds us the rarity of fire testimonies during Early Middle Palaeolithic (300–130 ky BP) on the scale of North-Western Europe. For Northern France, only the sites of Biache-Saint-Vaast and Therdonne present remains of combustion. At Biache-Saint-Vaast, it is not less than six levels, which present clues of combustion: burnt flint and faunal remains and sometimes charcoals. At Therdonne, besides burnt numerous flint and some rare faunal remains were brought to light during the excavation of level N3 several rich zones in organic residues and micro-charcoals. All the datas collected concerning the clues of combustion at Biache-Saint-Vaast and Therdonne is compiled, analyzed and interpreted. This approach permits to establish the fire use or its absence in saalian occupations of Neanderthals of Northern France and to discuss modalities of its use, particularly at Therdonne. To conclude, fire status and its implications in first Neanderthals occupations are briefly discussed.     

Précisions sur le patron d’empilement de dépôts du Cénomanien-Turonien de Somolinos (Chaîne Ibérique, Espagne) d’après l’étude palynologique

The Somolinos outcrop was widely studied in detailed correlations, stratigraphical architecture and high frequency sequence analysis of Central System and Iberian range successions. A rich assemblage of echinoids, ammonites, bivalves and bryozoans was described; conversely, the palynological study of the Late Cretaceous levels from Somolinos has never been performed up to now. A palynological study of two intervals within a monotonous alternation of grey marls and nodular limestone succession in the Somolinos section was carried out. The two intervals sampled are located in two correlative sequences of Late Cenomanian-Early Turonian and mid Turonian ages, respectively. Both sequences are separated by a sequence boundary, but its location and age in the stratigraphic record differs depending on the authors and the Basin considered. A rich palynofacies with abundant dinoflagellate cysts, pteridophyte spores, conifer pollens and breviary angiosperm grains of the normapolles group is described; besides, inner linings of acid resistant microforaminiferal tests were also found. The analysis of the palynological diagrams clearly indicates that the upper interval corresponds to open sea neritic sediments, deposited in more distal sedimentary environments than those of the lower interval, which were deposited in more proximal environments. This evolution of sedimentary environments represents a major sedimentary change in the general shallowing upwards trend of the late Albian-mid Turonian 2nd order succession, revealing a major facies belt retrogradation of the sequence containing the upper interval. This retrogradational event allows to accurately place the sequence boundary and to improve the arrangement of the low frequency (3rd order) depositional stacking pattern of the Early-mid Turonian in the Iberian Basin and other European and Tethyan basins.     

Technique du ganglion sentinelle dans le cancer de la prostate

Urological interest of sentinel lymph node procedure in prostate cancer, and methods, both are presented in conformity with the presentation of action concertée en medecine nucléaire (ACOMEN).     

Ressources complémentaires et mobilité dans le Magdalénien cantabrique. Nouvelles données sur les mammifères marins, les crustacés, les mollusques et les roches organogènes de la Grotte de Las Caldas (Asturies, Espagne)

Some animal and mineral resources, rarely identified in the levels of the Cantabrian Magdalenian, were exploited by the Paleolithic populations of the Nalón Valley (western Asturias) at the end of the Pleistocene. In this research, we present some of them, preserved in the Las Caldas Cave: dental remains and representations of marine mammals, marine crustaceans and molluscs, and diverse remains of amber and jet. These were selected, collected in ecosystems far away from the cave and, finally, transformed by the groups. These remains seem to complement the common resources exploited in Magdalenian paleoeconomy (e.g., ungulates, birds, fish, small carnivores, vegetables, flint, quartzite, quartz) recovered and exploited biotopes closest to the site. Our aim is thus to confirm a certain mobility of these communities towards the specific sources of raw material in search of subsistence resources potentially used in the activities of these communities (e.g., food, technology, social and symbolic expression, exchange).     

L’industrie aurignacienne de la grotte de Šandalja II (Istrie, Croatie) dans le contexte de la région de l’Est de l’Adriatique

This paper presents the results obtained by lithic analysis of Early Upper Palaeolithic levels in Šandalja II Cave, Istria, Croatia. Technological and typological analysis of stone and typological analysis of bone artefacts have been carried out. Production of flakes in Aurignacian levels (G, F, E and E/F) is dominant, but blade and bladelets production is also present. Blades and bladelets were produced by direct soft hammer technique. Aurignacian people of Šandalja II produced their debitage mainly on local grey chert, which is often patinated. Šandalja II is one of the rare—if not the only—site with Aurignacian industry in eastern Adriatic region. The main reason for absence of such industry at other sites can be seen in scarce population or abandonment of some parts of this region.     

Valeur pronostique du curage ganglionnaire prophylactique dans le cancer différencié de la thyroïde

Objective

Although the efficacy of total thyroidectomy as the first step in differentiated thyroid cancer (DTC) management is well proven, it is always a matter of controversy whether prophylactic lymph node dissection improves prognosis and survival in DTC patients without suspicion of lymph node metastases either clinically or radiologically. The aim of this work is to study relapse rates in patients according to the initial presentation and type of surgery performed, in order to analyze the prognostic impact of lymph node dissection.

Patients and methods

One hundred and thirty patients with DTC were classified according to clinical presentation and type of surgery performed. They were monitored for six years to watch for recurrence.

Results

In patients with no clinical evident lymph nodes, the relapse rate was lower among patients who underwent total thyroidectomy in one step with prophylactic lymph node dissection.

Conclusion

Based on the results of other studies, and on our department experience of thyroid cancer management and monitoring, we strongly advocate careful and systematic exploration of the central lymph node compartments with exploration of the lateral side of the lesion if in doubt.     

Apport de l’imagerie hybride TEMP/TDM dans la détection des ganglions sentinelles : à propos de 32 cas

Objectives

Retrospective evaluation of the SPECT/CT role in the Sentinel Lymph Node identification.

Patients and methods

Thirty-two patients underwent a lymphoscintigraphy with SPECT/CT imaging. Those patients presented several cancer types (16 melanoma, one squamous cell carcinoma, three breast cancers, eight vulvar cancers, three cervical cancers).

Results

The scintigraphic detection rate was 81% with planar imaging while this rate was 89% with SPECT/CT. The SPECT/CT provided an additional quantitative information in 66% cases. Moreover, the quality of the interpretation was better in two different conditions (planar interpretation followed by routine and blinded SPECT/CT interpretation) with SPECT/CT. In our study, the false negative rate is 4.5%.

Conclusions

SPECT/CT provides quantitative and qualitative informations in the sentinel lymph node detection. Therefore, it can be a valuable tool for the surgeon to find and harvest the sentinel lymph node especially where the lymphatic drainage pattern can be unusual or hard to predict (cervical or trunk localisation). It's a new tool for preoperative detection and it can decrease the false negative rate.