La variabilité graphique du Molí del Salt (Vimbodí, Catalogne, Espagne) et l'art mobilier de la fin du Paléolithique supérieur à l'est de la Péninsule Ibérique

The Upper Paleolithic of Catalonia has been so far characterized by a very weak presence of artistic representations. This scarcity was especially surprising if we take into account the huge number of discoveries from other zones of the Iberian Peninsula (Valencia, the Cantabrian region). In this paper we present four objects of portable art found at the Molí del Salt site (Vimbodí, Conca de Barberà, Tarragona). Below a mesolithic layer, dated to 8 ka BP, there is an Upper Magdalenian sequence with several dates between 10.8 and 12.5 ka BP. These magdalenian levels have yielded four plaques of schist with engravings, including several animal figurines and one human representations. Once the objects are described, we will place them in the context of the portable art from the Late Upper Paleolithic of Mediterranean Spain. From these data, the chronocultural successions based on the Upper Magdalenian-Microlaminar Epipaleolithic distinction will be discussed.     

Indices de fréquentation humaine dans les grottes à ours au Paléolithique moyen final: L’exemple de la Caverna Generosa dans les Préalpes lombardes, Italie

Already known like a palaeontological site for the study of Ursus spelaeus, Caverna Generosa also records ephemeral traces of human visits during the late Middle Palaeolithic. The cave opens at an altitude of 1450 m on the steep southern slope of the Monte Generoso Massif between the Lugano and the Como lakes and forms a complex group of narrow galleries and inner chambers. Sedimentological and palaeontological data and radiocarbon dates place both the cave-bear and the human frequentations in the first part of the isotopic stage 3 with climatic conditions shifting from cool and dry to more temperate and wet. Environment progressively changed from scarcely arboreal to arboreal-brush with small open spaces. Few flakes and Levallois flakes have been recovered scattered in the sediment and affected in most cases by intense postdepositional alteration. These items testify incursions of mousterian groups equipped with end-products and radiolarite flakes struck from blocks provisioned at lower locations southwards. End-products, namely Levallois flakes, prove that lithic reduction sequences were spatiotemporally fractionated in the covered territory. Conversely, it cannot be excluded a priori that sublocal radiolarite has been chipped at the entrance of the cave or at the very close surroundings for extraction of rudimental tools for immediate use. It is worth to mention that the small chert slabs in the Moltrasio limestone which crop throughout the cave walls were totally ignored. Caverna Generosa can be viewed as a refugia-location used in function of more or less constrained factors strongly influenced by high-altitude and bioclimatic situations. This type of site might well be integrated within the seasonal movements of humans in the western Lombard Pre-Alps area.     

Les cultures moustériennes en Ligurie italienne : analyse du matériel lithique de trois sites en grotte

Multidisciplinary studies realized these last years about cave sites of Madonna dell’Arma, Arma delle Manie and Santa Lucia superiore, in italian Liguria, have stated precisely the conditions of neandertalian frequentations of those sites, placing at intervals, according to the cases, from isotopic stage five to the beginning of stage three. The mousterian industries recovered in those sites, associated with a lot of faunal remains, are here analyzed about the different stratigraphic levels in each site. In Madonna dell’Arma and Arma delle Manie, those industries show a certain constancy in the different levels, about technological and typological point of view or about raw material management. In Santa Lucia superiore, on the contrary, two different types of occupation have let lithical vestiges with different facies in lower levels and above levels. For the three sites, the analysis of the raw material management shows an essentially local supplying, but also some origins much more far like in the case of the jasper. This carrying of distant stones reveals us one aspect of the mobility or at least the territories extension that were able to apprehend those neandertalian human groups in Liguria region and beyond also. Otherwise, some preferential choices for certain raw materials were done by knappers for the débitage or for the small retouched tool supports. The flaking technics are identified in each site and certain regularities have been stated, like the high frequency of Levallois flaking in the different levels (also external levels) of Madonna dell’Arma site that is not the case in the two other sites.     

Paléolithique supérieur et Mésolithique en Méditerranée : cadre culturel

The origin of the Upper Palaeolithic around the Mediterranean was the result of the local evolution, particularly in the Near East and in the Lower Nile basin, and of the migration from this zone to South-Eastern and Central Europe. The Initial Upper Palaeolithic in the Near East belt was the effect of local evolution from the industries based on Levallois concept to the industries which developed leptolithic blade technologies. This evolution is well registered in multi-layer sites in the Syro-Palestinian belt (Emirian/Ahmarian), which was the starting point of the diffusion of these “transitional” industries in South-Eastern and Central Europe. This diffusion could be identified with the migration of first anatomically Modern Humans. The Early Upper Palaeolithic in Europe — dated to the second half of the Interpleniglacial — was, at least partially, based on these “transitional” industries and manifested by the appearance of the Aurignacian, contrasted with local cultures such as the Uluzzian in Mediterranean Europe. During whole the Interpleniglacial Europe was separated from Northern Africa dominated by local evolution of Middle Palaeolithic (Middle Stone Age) cultures (mostly expressed by the Aterian), and by specific “transitional” industries on the southern Mediterranean coast (Early Dabbian) and in the Lower Nile basin. The Last Glacial Maximum and the corresponding sea level recession opened new possibilities of contacts between the Maghreb and the Iberian Peninsula in both directions (Aterian-Solutrean and Gravettian-Early Iberomaurusian), which are still difficult to be proved before new chronostratigraphic correlations are made. At the same time we register links between south-eastern Europe and western Anatolia; the real border between Near Eastern and European Mediterranean cultural zones was marked, in the Late Glacial, by the Taurus chain. During the Late Glacial the cultural separation between Europe and Africa was particularly marked. Only in the Aegean basin the first sea navigation facilitated contacts which become widespread as late as in the Early Holocene with neolithization trough maritime contacts.     

Découverte d’un site d’art rupestre en Cyrénaïque (Libye) : Kaf Tahr

In April 2009, a new rock art site was discovered in Libya. Kaf Tahr is situated in Cyrenaica, in the Djebel Akhdar (the “green mountain”). This new site with engravings displays several interests. Firstly, it is only the third rock art site discovered - or at least published - in Cyrenaica. Secondly, this rock shelter is the only one that had shown engravings belonging to at least two different chronological periods, the first one being very probably prehistoric, and the second, post-prehistoric. Finally, the engraving of a man (with a sword and a shield) and the engraving of a horse are the first discovered in the area. These two engravings could have been realized in the protohistoric period. This period is well-known in the Libyan Fezzan (“libyco-berberian period” or “horse period”) but it has never been defined in Cyrenaica. Owing to the lack of research, the long period separating the end of Prehistory from the beginning of the greek colonization is hitherto totally unknown. If these engravings would belong to this period, they would be the first elements attesting of a metal work and a horse domestication in Cyrenaica before the historic period.     

Conception et exécution de bases de données intégrées pour l'analyse des rapports spatiotemporels des artefacts du Paléolithique

The archaeologists excavate the historic site and analyze data from the excavation site. Therefore, they study about the past affairs and circumstances unknown to the world. These data are composed of stones, plants, bones and geological features, which are stored in separate files according to the fields of study. It is important to mention that this information become the first step toward the solution of some hypothesis in Archaeology. Therefore, we need the system that can not only support integrated environment to find clues of the past, but also manage existing artifact data systematically and grasp relationships among the data. In this paper, we modeled the time, which is used in archaeology and geology, and built an entity relationship database to store Paleolithic data excavated in Jungwon region site of the Republic of Korea as one resource, which seem to give a base for integrated research and relationships in archaeology. In addition, we developed the Graphic User Interface that allows various users to connect to the established system through the web.     

Puycelci, nouveau site à vertébrés de la série molassique d’Aquitaine. Densité et continuité biochronologique dans la zone Quercy et bassins périphériques au Paléogène

After the previous lacking evidence allowed the interpretation of a non-deposition episod, the newly recorded mammal fauna from Puycelci (Tarn, SW France, close South to the Quercy paleokarstic area) now shows the MP 26 standard level (Late Oligocene, Early Chattian) being represented within the Eastern Aquitaine molassic basin filling. According to the evolutionary stage of known mammal lineages, the most significant Puycelci fossils are the Issiodoromys pauffiensis rodent and the Metriotherium cf. sarelense nov. sp. (described in this paper) artiodactyl ungulate. This new dating exemplifies the improvement of the mammalian biochronologic record as regards both the Quercy paleokarst and the surrounding lacustrine Tertiary basins W, S, and S-E to the Quercy, as well as, directly E and N-E, the smaller tectonic Tertiary basins within the crystalline Massif Central basement. The updated record shows the strong extension in time of the paleokarstic data, down to the Middle and Early Eocene, and up to the Early Miocene. Regarding the classically reported Late Eocene to Late Oligocene span, as well in the paleokarst and the peripheral basins, the available biochronological data now attains a valuable density level, the variation of which is significant. On one side there are periods (Late Eocene, Early Oligocene, Early Late Oligocene) with high biochronologic density, allowing improved time resolution using evolutionary stages within mammalian lineages (e.g. numerical ages). Such periods corresponds to almost continuous sedimentary processes, with only possible short breaks. On the other side, there are periods with unreported data, shared in the paleokarst and peripheral basins (Late Oligocene as best example). Such periods may well correspond to some non-deposition episods as once alleged by geologists. Then the surrounding biochronologic data would bear constraining value regarding these episods.     

Baume Flandin et Abri du Maras : deux exemples de débitage laminaire du début du Pléistocène supérieur dans la Vallée du Rhône (sud-est, France)

Assemblages with blades are rare in the south of Europe and most of them are dated from the isotopic stages 4 and 3. The blades are, otherwise, often produced on Levallois cores with unipolar and bipolar methods. According to the sites, the blades are more or less retouched as different kinds of tools. However, there are no specific links between this blank and the tools, and never between the artefacts and the fauna remains (activities). The hypothesis of traditions or needs among time and space are asked without answer, while the blades are present in the north of Europe and the Near East in far older periods. Several sites can be considered to describe the variability of the technical behaviour and the archaeological context of the blades in south-east France, extending to north Italy. The two sites, Abri du Maras and Baume Flandin, located in the middle Rhône valley, yield evidence of a laminar debitage linked to a Levallois method and a “direct” method. The technical choices used in the two sites are accorded to the specificity of the laminar assemblages in the southern Europe.     

Resolving protein structure‐function‐binding site relationships from a binding site similarity network perspective

Functional annotation is seldom straightforward with complexities arising due to functional divergence in protein families or functional convergence between non‐homologous protein families, leading to mis‐annotations. An enzyme may contain multiple domains and not all domains may be involved in a given function, adding to the complexity in function annotation. To address this, we use binding site information from bound cognate ligands and catalytic residues, since it can help in resolving fold‐function relationships at a finer level and with higher confidence. A comprehensive database of 2,020 fold‐function‐binding site relationships has been systematically generated. A network‐based approach is employed to capture the complexity in these relationships, from which different types of associations are deciphered, that identify versatile protein folds performing diverse functions, same function associated with multiple folds and one‐to‐one relationships. Binding site similarity networks integrated with fold, function, and ligand similarity information are generated to understand the depth of these relationships. Apart from the observed continuity in the functional site space, network properties of these revealed versatile families with topologically different or dissimilar binding sites and structural families that perform very similar functions. As a case study, subtle changes in the active site of a set of evolutionarily related superfamilies are studied using these networks. Tracing of such similarities in evolutionarily related proteins provide clues into the transition and evolution of protein functions. Insights from this study will be helpful in accurate and reliable functional annotations of uncharacterized proteins, poly‐pharmacology, and designing enzymes with new functional capabilities. Proteins 2017; 85:1319–1335. © 2017 Wiley Periodicals, Inc.     

Comparison of RFLP and RAPD markers to estimating genetic relationships within and among cruciferous species

Restriction fragment length polymorphism (RFLP) and random amplified polymorphic DNA (RAPD) markers are being used widely for evaluating genetic relationships of crop germplasm. Differences in the properties of these two markers could result in different estimates of genetic relationships among some accessions. Nuclear RFLP markers detected by genomic DNA and cDNA clones and RAPD markers were compared for evaluating genetic relationships among 18 accessions from six cultivated Brassica species and one accession from Raphanus sativus. Based on comparisons of genetic-similarity matrices and cophenetic values, RAPD markers were very similar to RFLP markers for estimating intraspecific genetic relationships; however, the two marker types gave different results for interspecific genetic relationships. The presence of amplified mitochondrial and chloroplast DNA fragments in the RAPD data set did not appear to account for differences in RAPD- and RFLP-based dendrograms. However, hybridization tests of RAPD fragments with similar molecular weights demonstrated that some fragments, scored as identical, were not homologous. In all these cases, the differences occurred at the interspecific level. Our results suggest that RAPD data may be less reliable than RFLP data when estimating genetic relationships of accessions from more than one species.     

Nitrogen starvation-induced chlorosis in Synechococcus PCC 7942. Low-level photosynthesis as a mechanism of long-term survival

Cells of the non-diazotrophic cyanobacterium Synechococcus sp. strain PCC 7942 acclimate to nitrogen deprivation by differentiating into non-pigmented resting cells, which are able to survive prolonged periods of starvation. In this study, the physiological properties of the long-term nitrogen-starved cells are investigated in an attempt to elucidate the mechanisms of maintenance of viability. Preservation of energetic homeostasis is based on a low level of residual photosynthesis; activities of photosystem II and photosystem I were approximately 0.1% of activities of vegetatively growing cells. The low levels of photosystem I activity were measured by a novel colorimetric assay developed from the activity staining of ferredoxin:NADP+ oxidoreductase. Photosystem II reaction centers, as determined by chlorophyll fluorescence measurements, exhibited normal properties, although the efficiency of light harvesting was significantly reduced compared with that of control cells. Long-term chlorotic cells carried out protein synthesis at a very low, but detectable level, as revealed by in vivo [35S]methionine labeling and two-dimensional gel electrophoresis. In conjunction with the very low levels of total cellular protein contents, this implies a continuous protein turnover during chlorosis. Synthesis of components of the photosynthetic apparatus could be detected, whereas factors of the translational machinery were stringently down-regulated. Beyond the massive loss of protein during acclimation to nitrogen deprivation, two proteins that were identified as SomA and SomB accumulated due to an induced expression following nitrogen reduction.     

Parent–youth agreement on symptoms and diagnosis: Assessment with a diagnostic interview in an adolescent inpatient clinical population

Diagnostic information on adolescents may be elicited from both youths and their parents, especially for depressive and suicidal symptomatology. The objective of this study was to examine the degree of agreement between parent and adolescent reports of major psychiatric disorders, at the diagnostic and at the symptom level, in a severely affected inpatient clinical population. 64 parent–adolescent pairs were interviewed separately with the semi-structured diagnostic interview Kiddie-SADS-PL. Symptomatology was also assessed with 11 self-report and parent-report scales, all translated, adapted and in most cases validated in Iceland. A total of 25 subscales were included to assess emotional dimensions such as depression or anxiety and cognitive dimensions such as attention deficit or self-concept. Good agreement was found for social phobia and fair agreement for generalized anxiety disorder. Although parent–youth agreement was poor in most cases at the symptoms level, significant correlations indicated consistency for most severity scores, except those related to depressive symptomatology, attention deficit, separation anxiety or conduct disorder. The low agreement between reports of suicidal ideation is in line with results from previous studies and suggests that parents might under- or over-estimate this symptomatology. The combination of data obtained with diagnostic interviews and rating-scales confirmed results from prior empirical work, giving greater weight to parents’ reports of observable behavior and to adolescents´ reports of subjective experiences, especially depressive symptomatology. Our findings suggest that both parent and child informants are necessary to obtain adequate assessments in adolescents. Further research should explore the correspondence between discrepant diagnoses and external criteria such as parental psychopathology or parent–child relationships and attachment. Psychoanalysis could benefit from cognitive neuroscience and use cognitive assessments as interesting tools. Thus, cognitive assessments can show discrepant results according to parents’ or adolescents’ reports and can therefore shed light on the parent–child interaction and relational dynamics. Inversely, cognitive neuroscience could benefit from psychoanalysis by taking into account, when interpretating the scores, the relational dynamics and the personal history of the rater.     

Profile of Digestive Enzymes Activity During Early Development of Featherback <Emphasis Type="Italic">Chitala chitala</Emphasis> (Hamilton, 1822)

The ontogenetic development of the key digestive enzymes of featherback Chitala chitala was assayed during the early development. Amylase, lipase, trypsin and chymotrypsin activities were detected on 1 days after hatch (DAH), (during endotrophic stage) but pepsin activity was detected on 12 DAH (exotrophic phase) correlated with the improvement of gastric secretion at the beginning of flexion stage. The gradual shift of alkaline protease activity (trypsin and chymotrypsin) to more efficient acidic digestion indicated a change in the digestive physiology as a result of metamorphosis acquiring the juvenile characteristic during the postflexion or extrophic phase. The initial high level of amylase (i.e. from 1 DAH to 9 DAH) during endotrophic and endoexotrophic feeding stage could be better explained as a result of programmed gene expression. But a constant decrease in activity after the 12 DAH i.e. on the onset of flexion and exotrophic stage of featherback fish in the present study may be possibly due to the developmental changes in the gut morphology and increased protein level in the tissue. These fluctuations of the enzymatic activities in featherback larvae reflect the ability of the fish to adapt with the diet during ontogenetic shift. This information can lead to the possibility of developing an age specific formulated feed for intensive farming of this new candidate species.     

La stratigraphie du Pléistocène supérieur et le Paléolithique en Corée

In Korea, Quaternary deposits are characterized by marine and fluvial terrace deposits, commonly found in the coastal areas and at the sides of river valleys. The major terraces are classified into 5 different levels, i.e., alluvial plain (3-5 m asl), lower terrace (10-25 m asl), middle terrace (33-50 m asl), high terrace (55-85 m asl), and highest terrace (90-160 m asl). They were formed by the repetition of sedimentation and erosion due to sea level fluctuation and uplifting along the coastal areas during Quaternary period. The formation age of the lower marine terraces at the level of 10-20 m is interpreted to be the last interglacial (75-125 Ka, MIS = 5a-5e). The middle coastal terrace gravels distributed at the level of about 33-45 m above mean sea level and are to be formed before the last interglacial. Above coastal terrace deposits, slope deposits and paleosol layers are overlain and freezing and thawing crackings were developed in them. Major prehistory archaeological sites in the coastal areas are found in the slope deposits formed during last glaciations. The upper parts of the slope deposits are typified by paleosol layers with typical frost cracks (soil wedges) and frangipanes. As geochronological bases for subdividing Paleolithic cultures, two typical paleosol layers are useful because they are mostly found and imprinted with several horizons of frost cracks or soil wedges. The uppermost crack structures were formed under the boreal-periglacial climatic regime during the last glacial period of extremely cold-dry climate in Korea. The upper pedogenetic sediments containing frost cracks or soil wedges were formed between 24 and 17 Ka in many Paleolithic profiles. The lowermost paleosol layer with frost cracks (soil wedge), strongly attacked into hillslope sediments or last interglacial saprolite layers on the weathered basement rocks, were detected at least as old as 59-74,000 Ka. Lastly upper Paleolithic cultural layers were found in the young fluvial deposits, which had been formed since the Last Glacial Maximum (LGM). Some of them were particularly continued as late as the Pleistocene-Holocene Transition Period.     

La gestion du quartz au Pléistocène moyen et supérieur. Trois exemples d’Europe Méridionale

Quartz is one of the main lithic resources employed along the Pleistocene for the manufacturing of tools. The abundance in all kind of environments leads to its frequent presence in archaeological sites. In spite of its suitability for knapping, the scarcity of specific researches on quartz industries has led to a view of this raw material as a second-rate resource, only used when flint was not available in the surroundings. Quite in opposition to this prejudice, the familiarity with the petrological and mechanical properties of the different varieties of quartz has led the Middle/Upper Pleistocene groups to a rational and differential exploitation of the available resources. There is a distinct selection of the varieties attending to the purposes of the exploitation and configuration. The patterns of exploitation of the cores are very standardized, based on longitudinal extractions and documenting the bipolar flaking technique. Moreover, when the raw material is of good quality, more sophisticated reduction methods such as the discoidal or the Levallois may be employed. On the other hand, for the purposes of configuration a clearly differential management of the raw material is attested: thus quartz is used for the small products (denticulates, side-scrapers, notches), while other stones (quartzite, porphyry and others) are devoted to the manufacturing of those tools demanding a more complex control of the elaboration (bifaces, cleavers, etc.). Either acting as the main lithic resource or as a complement to other raw materials, we can observe through the technological analysis of these lithic collections the great conceptual complexity depending on the needs to be fulfilled. Raw material quality allowing, the state-of-the-art technology of knapping can be applied to the quartz and, therefore, we should not understand its use as a consequence of environmental constrictions but rather as a result of the variability of the procurement strategies and management of lithic resources among the prehistoric communities.     

Métastase méningée révélatrice de cancer thyroïdien multimétastatique

We report the case of a 74-year-old patient who presented with cognitive disorders. Morphological imaging showed a tumor which was considered as a meningioma. Surgical resection of this tumor was performed and pathology indicated a meningeal metastasis of a thyroid cancer. The patient had previously a thyroidectomy with an initial benign pathology report. Meningeal metastases of thyroid cancer are rare, and a meningeal metastasis revealing a thyroid cancer is very rare.     

Le Lias et le Dogger du sud du Bassin parisien (France) : rôle de la tectonique syn-sédimentaire et reconstitutions paléogéographiques à l'échelle de la biozone d'ammonite

The Lias and Dogger series in the southern Paris Basin outcrops are precisely dated following the ammonite biozonation scale. In these series, the depositional environment context is accurately identified and thus various isopic zones can bee recognized. From the outcrop study, the depositional sequence and the tectonics events are also distinguished. The poorly dated subsurface data should be not anymore interpreted as diagraphic signatures, with the traditional peak to peak correlation. They now need to be analysed according to the geodynamic evolution of each isopic zone. The Liassic transgressive series (in the Armorican continent) and the Dogger platforms numerous carbonate bodies are correlated at biostratigraphic scale, throughout the whole southern Paris Basin. Subsequently, paleogeographic maps are established and based on depositional sequences. The basin evolution image changes radically. This shows clearly that the complexes carbonate bodies layout prohibits any depositional environment interpretation and any isopach mapping at geological stage level. If not, the carbonate platforms of different age would be amalgamated, without any connection with the reality. Over the time, paleogeographic maps show syn-sedimentary short wavelength deformations, more or less well expressed according to the local sedimentary context. During the Lias and the Dogger, three steps can be distinguished in the southern Paris Basin. Hettangian to Lower Aalenian, the progressive increase in accommodation drives to total immersion of the continental areas; the maximum of accommodation during the Middle Toarcian entails uniform sedimentary conditions. However, short wavelength deformations persist. The major accidents defining the isopic zones are mainly North-South oriented. Middle Aalenian to Middle Bathonian, isopic zones are contrasted, controlled by the North-South accidents but also the North West-South East ones ; the variable accommodation allowed the development of regional sedimentary gaps and shallow limestone progradations on a marly area (so called “Sillon marneux”) ; tectonics events correspond to the Tethyan and the North Sea riftings influences. Upper Bathonian to Upper Oxfordian, the North West-South East tectonics accidents are particularly active; this tectonic phase could be associated to the thermal event, described in the Paris Basin and announcing the Malm depositional environment.     

Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities

Studies were conducted to explore relationships in rat liver between retinyl palmitate hydrolase activity and the hydrolytic activities against cholesteryl oleate and triolein. Previous studies have shown positive correlations between these three lipid ester hydrolase activities. In order to extend this work, the hydrolase activities were further purified and characterized. The activities against cholesteryl oleate and triolein resembled retinyl palmitate hydrolase activity in showing great variability from rat to rat as assayed in vitro. The relative levels of the three activities were highly correlated with each other over a 50-fold range of activity in a series of 66 liver homogenates. Partial purification (approx. 200-fold) in the absence of detergents was achieved by sequential chromatography of an acetone powder extract of liver on columns of phenyl-Sepharose, DEAE-Sepharose and heparin-Sepharose. The three hydrolase activities copurified during each of these chromatographic steps. The properties of the three copurifying activities were similar with regard to stimulation of activity by trihydroxy bile salts, pH optimum (near 8.0), and observance of Michaelis-Menten-type saturation kinetics. The three activities were different in their sensitivity towards the serine esterase inhibitors diisopropylfluorophosphate and phenylmethanesulfonyl fluoride, and in their solubility properties in 10 mM sodium acetate, pH 5.0. Thus, triolein hydrolase activity was much less sensitive than the other two activities to the two inhibitors. In addition, the activity against cholesteryl oleate could be separated from the other two activities by extraction of an acetone powder with acetate buffer, pH 5.0. These results indicate that the three lipid hydrolase activities are due to at least three different catalytically active centers, and at least two distinct and separable enzymes. It is likely that three separate but similar enzymes, that appear to be coordinately regulated, are involved.     

Une dent humaine perforée découverte en contexte Gravettien ancien à l’abri Pataud (Dordogne, France)

The existence of an Early Gravettian perforated human tooth at the abri Pataud came to light thanks to the reexamination of the osseous artefacts from the level 5. Even if the method of perforation of this tooth is analogous to the one used to pierce the animal teeth discovered in the same level, this pendant would have a particular meaning.