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1.
Reza Amani Somaye Saeidi Zahra Nazari Sorour Nematpour 《Biological trace element research》2010,137(2):150-158
It has been suggested that mood disorders and depressive status may be accompanied by lowered zinc status in the body, and
adequate consumption of zinc increases a general perceived well-being. The main objective of this study was to assess the
correlation between serum zinc concentrations and dietary zinc intakes with depression scores in university female students.
In the first phase, Beck's depression questionnaire was applied in a random sampling of 308 selected 20–25-year-old female
students (one third of total students in Ahvaz Jondi-Shapour University of Medical Sciences Golestan dormitories) to assess
the major depressive disorder (MDD) scales. Then, in the second phase, 23 students who identified as having moderate and severe
depression were selected as the case group, and 23 healthy age matched were chosen as the controls. Each of them completed
a 12-item semiquantitative food frequency questionnaire containing the main food sources of zinc in the usual dietary patterns
and also a 24-h food recall questionnaire to assure the daily zinc intakes. Daily zinc intakes were obtained by multiplying
each portion size by its zinc content using food tables. A 5-ml blood sample was taken for further serum zinc status using
flame atomic absorption spectrophotometry technique. Pearson's r was used to show the correlation between quantitative variables. Both daily zinc intake and serum zinc concentrations of
MDD group were about two thirds of healthy index (p < 0.01). Depressed individuals used to eat lower servings of red meats and chicken as the main food sources of zinc in students'
usual diets (p < 0.001). Consumption of other foods as the sources of zinc was not significantly different in two groups. A linear significant
correlation between dietary zinc intakes and its serum levels was seen in samples (r = 0.62; p < 0.001) and MDD students (r = 0.55; p < 0.001). There was a linear inverse correlation between Beck questionnaire scores and serum zinc concentrations in all of
the investigated students(r = -0.65; p < 0.001) and MDD girls (r = −0.71; p < 0.001). Beck questionnaire scores and diatary zinc intakes were also inversly correlated (r = −0.58; p < 0.001). However, no statistical correlation was seen between these two variables in MDD cases. In depressed female students,
dietary zinc intake is correlated to its serum concentrations; however, the serum zinc levels are inversely correlated to
depression scales. Consumption of the main dietary sources of zinc such as red meats and chicken should be encouraged in young
depressed girls. 相似文献
2.
Milan Dastych Dagmar Procházková Antonin Pokorný Libor Zdražil 《Biological trace element research》2010,133(3):265-269
The purpose of this study was to determine the different levels of copper and zinc in the serum, urine, and scalp hair of
patients with Wilson’s disease receiving different, currently accepted methods of treatment to reduce the copper load (penicillamine—group
1, n = 8; zinc—group 2, n = 8; penicillamine+zinc—group 3, n = 8). Blood, urine, and hair samples were collected from the patients. All three treatments resulted in a significant decrease
of the serum copper levels. Significantly increased levels of zinc in the serum were detected in the patients in groups 2
and 3 (19.1 and 18.8 μmol/l, respectively; p < 0.05). Copper excretion in the urine significantly increased during its administration to groups 1 and 3 (11.5 and 7.94 μmol/24 h
respectively; p < 0.001) due to the effect of penicillamine. The administration of zinc as monotherapy (group 2) or in combination with penicillamine
(group 3) led to an increase of its excretion (25.3 and 22.4 μmol/24 h, respectively; p < 0.01). Only an insignificant rise of the copper content in the hair was found in all three groups of patients. The content
of zinc in the hair did not differ significantly in any of the groups in comparison with the control group. 相似文献
3.
Relationship between synovial fluid and plasma manganese,arginase, and nitric oxide in patients with rheumatoid arthritis 总被引:3,自引:0,他引:3
Nitric oxide (NO) participates in the pathogenesis of inflammatory reactions in many autoimmune diseases such as rheumatoid
arthritis (RA). There is a reciprocal pathway between arginase and nitric oxide synthese (NOS) for NO production, and Mn is
required for arginase activity and stability. To investigate whether NO production related with the arginine-nitric oxide
pathway in patients with RA, we measured synovial fluid and plasma nitrite (NOx) levels, arginase activities, and its cofactor manganese (Mn) concentrations in 21 RA patients and 13 healthy control subjects.
Plasma albumin levels were measured as an index of nutritional status. NOx levels were determined after the reduction of nitrates to nitrites using the Griess reaction. Whereas, synovial fluid arginase
activities and Mn levels were found to be significantly lower (p<0.001, p<0.001, respectively), plasma arginase activities and Mn levels were similar in patients with RA when compared to the control
subjects. Plasma and synovial fluid NO levels were similar in patients with RA and in healthy subjects (p>0.05, p>0.05, respectively). There were significantly positive correlations between synovial fluid and plasma arginase activities
vs Mn content (r=0.543, p=0.011; r=0.516, p=0.017, respectively) and significantly negative correlations between synovial fluid and plasma NO levels vs arginase activities
(r=−0.497, p=0.022; r=−0.508, p=0.019 respectively) in the patients group. Our results indicate that the lower concentration of synovial fluid Mn could cause
lower arginase activity and this could also upregulate NO production by increasing L-arginine content in patients with RA. 相似文献
4.
Excessive Zn but normal Cu and Mg in the staple food consumed by the people of Chandigarh (Union territory and capital of
Punjab and Haryana States of India) has been considered to be the major risk factor for the prevalence of obesity (33.15%)
and obesity-related diseases in this region. Therefore, in the present investigations, in obesity-related diseases, the status
of these minerals was estimated in their tissues, including hair, nails, and blood serum and urine, and compared with those
of normal subjects. They were grouped as: normal subjects in control Group A, middle-aged diabetics in Group DM, older diabetics in Group DO, and diabetics with osteoarthritis in Group D+ OA, osteoarthritis in Group OA and rheumatoid arthritis in Group RA, respectively.
The results evaluated in the order as: hair Zn, group D+OA>DM>OA>A (control)>RA>DO (p < 0.001); hair Cu, group A (control)>DM>OA>D+OA>DO>RA (p < 0.001); hair Mg, group A (control)>DM>OA>D+OA>RA>DO (p < 0.001, 0.01); hair Mn, group A (control)>RA>OA>D-OA>DM>DO (p < 0.001); nail Zn, group DM>D+OA>OA>A (control)>RA>DO (p < 0.001, 0.05); nail Cu, group A (control)>OA>DM>D+OA>RA>DO (p < 0.001); nail Mg, group A (control)>OA>DM>DO>D+OA >RA (p < 0.001); nail Mn, group A (control) >RA>OA>D+OA>DM>DO (p < 0.01); urine Zn, group DO>DM>D+OA>A (control)>RA>OA (p < 0.01); urine Cu, group RA>D+OA>DO>OA> DM>A (control) (p<0.001); urine Mg, group RA>OA>D+OA>DO>DM>A (control; p < 0.001); urine Mn, group DO>DM>OA>D+OA>RA>A (control; p < 0.001), respectively. The analysis of the mineral status in serum of diabetics further showed their highly significant
rise from lower mean age subgroup to higher mean age subgroup than their control counter parts (p < 0.001, 0.01, and 0.05) with coincident deficiencies of Cu, Mg, and Mn in their tissues. This study would be helpful considering
the status of minerals in these obesity-related diseases depending on the choice of the food consumed to improve the quality
of life and prognosis for the diseases. 相似文献
5.
6.
Interleukin-18 gene polymorphism,but not interleukin-2 gene polymorphism,is associated with rheumatoid arthritis 总被引:1,自引:0,他引:1
To investigate whether polymorphisms of IL-2 and IL-18 genes are associated with rheumatoid arthritis (RA), polymorphisms of IL-2 and IL-18 genes were detected by polymerase-chain-reaction-based restriction analysis in the patients with RA and normal controls.
The results for the IL-18 gene revealed a significant difference between the patients and the normal controls (p = 0.000003), but there was no significant difference for the IL-2 gene (p = 0.876). The IL-18 gene 105A allele was associated with RA in Chinese patients. Individuals possessing the 105A allele had a higher incidence
of RA. A lack of association of IL-2 gene polymorphism between RA patients and healthy individuals was noted. The results of this study provide genetic evidence
that IL-18-105A/C polymorphism may play an effective role in RA. 相似文献
7.
The objective was to determine the prevalence of iodine deficiency among hypothyroid patients and the effect of dietary goitrogens
on indices of iodine and thyroid status. This is a case-control study of 106 subjects who were recruited from King Abdulaziz
University Hospital, Jeddah. Blood and urine were collected for serum thyroid hormones, thyroid autoantibodies, thyroglobulin
(Tg) and urinary iodine concentration (UIC). Dietary iodine and goitrogenic food intake were assessed by questionnaire. Using
World Health Organization (WHO) cutoff values for UIC, both controls and cases were iodine deficient (85% and 83%, respectively).
Furthermore, dietary iodine was deficient in 23% of controls and 36% of cases. In cases, there was a positive association
between UIC levels and serum thyroid stimulating hormone (r = 0.405, p < 0.01) and a negative association with serum fT4 (r = −0.358, p < 0.01). Serum Tg antibody titers were also positively associated with dietary iodine (r = 0.328, p < 0.05). Patients with elevated serum autoantibodies had lower UIC and dietary iodine than those with normal serum autoantibodies.
UIC was associated with dietary goitrogens including turnip (r = 0.280, p < 0.05) and pine (r = 0.289, p < 0.05) among cases. Iodine deficiency is common and the consumption of dietary goitrogens is high among euthyroid and hypothyroid
subjects living in Jeddah. 相似文献
8.
In this study, copper, zinc, magnesium, manganese, selenium, and iron of urine and hair were measured in the patients with
tuberculous (TB) pleurisy (n = 24) and in the control group (n = 20). Selenium, magnesium, and zinc of hair were found to be significantly lower in TB pleurisy cases than those in the
control group (p < 0.05, p < 0.001, and p < 0.01, respectively). On the contrary, selenium and magnesium of urine were found to be significantly elevated in TB pleurisy
cases than those in the control group (p < 0.05 and p < 0.001, respectively). There was no significant difference in the value of manganese and iron between TB pleurisy and the
control group (p > 0.05). Copper level were significantly increased in hair and decreased in urine of the patients (p < 0.01). The occurrence of these abnormalities constitutes new information regarding trace elements in TB pleurisy patients.
These results may provide an additional disease correlate for assessing TB pleurisy risk. 相似文献
9.
Manouchehr Nakhjavani Afsaneh Morteza Leila Khajeali Alireza Esteghamati Omid Khalilzadeh Firouzeh Asgarani Tiago F. Outeiro 《Cell stress & chaperones》2010,15(6):959-964
The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types
of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70
in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy
control group (n = 36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n = 36) and patients with diabetes duration of more than 5 years (n = 37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum
HSP70 levels were significantly higher in patients with diabetes when compared with controls (p < 0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p < 0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r = −0.500, p = 0.002), positively correlated with the history of hypertension in newly diagnosed patients (p < 0.001), and positively correlated with age in patients with diabetes (r = 0.531, p = 0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease.
Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course
of diabetes. 相似文献
10.
In recent years, a great number of studies have investigated the possible role of trace elements in the etiology and pathogenesis
of rheumatoid arthritis (RA) and osteoartritis (OA). We studied synovial fluid and plasma concentrations of selenium (Se),
zinc (Zn), copper (Cu), and iron (Fe) in patients with RA and OA and compared them with sex- and age-matched healthy subjects.
Plasma albumin levels were measured as an index of nutritional status. Plasma Se, Cu, and Zn concentrations were determined
by atomic absorption spectrophotometry and Fe concentrations were determined by the colorimetric method. Although plasma and
synovial fluid Se concentration were found to be significantly lower (p<0.05, and p<0.05, respectively), Cu concentrations were significantly higher in patients with RA than those of healthy subjects and OA
(p<0.05 and p<0.05, respectively). There were no significant differences in plasma and synovial fluid Zn concentrations and albumin levels
among three groups (p>0.05). On the other hand, synovial fluid Cu and Fe concentrations were significantly higher in patients with OA than those
of healthy subjects (p<0.05). There was a significantly positive correlation between synovial fluid Se−Cu values and Zn−Fe values in patients with
RA. Our results showed that synovial fluid and plasma trace element concentrations, excluding Zn, change in inflammatory RA,
but not in OA. These alterations in trace element concentrations in inflammatory Ra might be a result on the changes of the
immunoregulatory cytokines. 相似文献
11.
Olusi S Al-Awadhi A Abiaka C Abraham M George S 《Biological trace element research》2003,91(2):137-144
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there
are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated
the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older.
Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured
by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=−0.423, p<0.001). There was no significant association between serum leptin and zinc (r=−0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with
serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=−0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels. 相似文献
12.
Kader Köse Pakize Doĝan Yildiz Kardas Recep Saraymen 《Biological trace element research》1996,53(1-3):51-56
The plasma selenium (Se) levels were determined in patients with rheumatoid arthritis (RA) and healthy controls. Plasma Se
levels in 60 patients were found to be significantly lower than those in 60 normal, healthy controls (p<0.001). Similar significant differences were determined in sex-matched comparisons between patients and controls (p<0.001) but there was no significant difference in plasma Se levels in sex-matched comparisons in both groups (p>0.05).
Our results suggest that Se is an important factor in RA. 相似文献
13.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
14.
Casimiro-Lopes G de Oliveira-Junior AV Portella ES Lisboa PC Donangelo CM de Moura EG Koury JC 《Biological trace element research》2009,127(2):109-115
The purpose of this study was to compare plasma leptin, plasma zinc, and plasma copper levels and their relationship in trained
female and male judo athletes (n = 10 women; n = 8 men). Blood samples were obtained 24 h after training to measure plasma zinc, copper, and leptin levels. Subjects presented
similar values to age (22 ± 2 years old), body mass index (24 ± 1 kg/m2), plasma zinc (17.2 ± 2 μmol/L), copper (12.5 ± 2 μmol/L), and leptin (5.6 ± 1.3 μg/L). However, height, total body mass,
lean mass, fat mass, and sum of ten-skinfold thickness were higher in male than female. Plasma leptin was associated with
sum of ten skinfolds in male (r = 0.91; p < 0.001) and female athletes (r = 0.84; p < 0.003). Plasma zinc was associated with leptin in males (r = 0.82; p < 0.05) while copper was associated with plasma leptin in females (r = 0.66; p < 0.05). Our results suggest that young judo athletes lost sex-related differences in leptin levels. Plasma zinc, plasma
copper, and energy homeostasis may be involved in regulation of plasma leptin. 相似文献
15.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
16.
Ozkaya M Sahin M Cakal E Gisi K Bilge F Kilinc M 《Biological trace element research》2009,128(2):144-151
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR)
according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied
in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl,
p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9
vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine
levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. 相似文献
17.
Quihui-Cota L Méndez Estrada RO Astiazarán-García H Morales-Figueroa GG Moreno-Reyes MJ Cuadras-Romo D Canett-Romero R 《Biological trace element research》2012,145(3):396-402
The association of giardiasis with the malabsorption of zinc remains controversial. This study investigated changes in serum
zinc levels in Giardia-infected mice subjected to different dietary zinc regimens. Thirty-five mice (strain C3H/HeJ) were randomly categorized into two groups. The first group was inoculated with 5 × 106
Giardia trophozoites (n = 18), and the second group remained Giardia free (n = 17). Each group (Giardia infected and Giardia free) was randomly classified into three subgroups and given low (9 mg Zn/kg), normal (33 mg Zn/kg), and high levels (288 mg
Zn/kg) of dietary zinc over a 2-week period for acclimation. Fourteen days post-Giardia infection, all of the mice were euthanized and blood samples were collected. The number of trophozoites was quantified (hematocytometer),
and serum zinc levels were determined via atomic absorption spectrophotometry. Significant increases in the median weights
were only found in the Giardia-free mice (p < 0.05). A higher final median weight was found in the Giardia-free group when compared with that of the Giardia-infected group given low dietary zinc (p = 0.013). In the Giardia-infected group with low dietary zinc, the geometric mean of trophozoites was 3,498 ± 101 (SE) per milliliter. The Giardia-infected group had lower serum zinc levels than did the Giardia-free group with the high dietary zinc regimens (p < 0.05). Our results are consistent with studies among human populations, but further studies are required to elucidate the
actual mechanism governing the zinc–giardiasis interaction. 相似文献
18.
It is thought that calcium and magnesium may be related to metabolic disorders such as obesity and metabolic syndrome; however,
to date, there have been few studies investigating the association between serum calcium and magnesium levels and metabolic
syndrome in middle-aged male adults. We aimed to investigate the association between serum calcium and magnesium levels and
metabolic syndrome in Korean middle-aged male adults. Study subjects included 213 men aged 30∼60 years. MetS risk score is
determined by adding the number of risk factors, waist circumference, triacylglyceride (TG), HDL cholesterol, glucose, and
blood pressure (BP). The study population was divided into three groups according to the MetS risk score: group I (MetS risk
score ≤1; n = 106), group II (MetS risk score = 2; n = 51), and group III (MetS risk score ≥3; n = 56). The serum Ca, according to increase of MetS risk score, was significantly higher (p < 0.001), and there was no significant difference in serum Mg concentration among the three groups. Subjects with high TG
and high BP had higher serum calcium levels than those without such abnormalities. Subjects with higher glucose had lower
serum magnesium levels than those without such abnormality. The correlation analysis indicated that the serum Ca had positive
correlations with the MetS risk score (r = 0.1769, p < 0.01), serum TG (r = 0.2516, p < 0.001), and DBP (r = 0.2246, p < 0.01). The correlation analysis indicated that the serum Mg had an inverse relationship with serum glucose (r = −0.2404, p < 0.001). In conclusion, serum Ca had positive association with TG and BP, while serum Mg had negative association with serum
glucose after adjusting age and BMI among the middle-aged Korean male adults. 相似文献
19.
Eman M. Alissa Suhad M. Bahjri Waqar H. Ahmed Nabeel Al-Ama Gordon A. A. Ferns 《Biological trace element research》2009,131(3):215-228
Chromium deficiency is associated with impaired glucose tolerance (IGT) and dyslipidemia. Hence, the objective of the current
study was to investigate chromium status among Saudi men with and without established cardiovascular disease (CVD) and its
relationship to glucose tolerance, lipid profile and other established CVD risk factors. We measured serum and urine chromium
concentrations, fasted lipid profile, plasma glucose, and serum lipid peroxide in 130 Saudi men with an established history
of myocardial infarction and 130 age-matched controls without established CVD. Patients with established CVD had higher serum
triglycerides (p < 0.05) and plasma glucose (p < 0.0001) and lower serum and urinary chromium concentrations (p < 0.0001) than controls. Serum chromium was inversely correlated with plasma glucose among cases and controls (r = −0.189, p < 0.05 and r = −0.354, p < 0.00001, respectively). Plasma glucose (OR 1.127, CI 1.0–1.269, p < 0.05), serum chromium (OR 0.99, CI 0.985–0.995, p < 0.0001), and urinary chromium (OR 0.988, CI 0.981–0.995, p < 0.001) were independently associated with the presence of established coronary disease applying this model. While chromium
metabolism appears to be altered in individuals with CVD, it is unclear whether chromium supplementation would be effective
in CVD prevention among patients with IGT. This would need to be tested in long-term outcome trials. 相似文献
20.
Studies of five microelement contents in human serum, hair, and fingernails correlated with aged hypertension and coronary heart disease 总被引:6,自引:0,他引:6
Yu-Rong Tang Shu-Qin Zhang Yin Xiong Yu Zhao Hua Fu Hua-Ping Zhang Kai-Min Xiong 《Biological trace element research》2003,92(2):97-103
Using atomic absorption spectrometry (AAS), five microelements in human serum, hair, and fingernails of aged hypertension,
coronary heart disease (diseased group) and aged health control (healthy group) were detected. Results of the t-test are as follows: The iron, zinc, and cadmium contents and Zn/Cu (mol/mol) ratio of the diseased group were significantly
higher than that of the healthy group in serum (p<0.01, p<0.05, p<0.01, and p<0.05, respectively); the chromium contents in the serum, hair, and fingernails (p<0.05, p<0.01, and p<0.05, respectively); the iron and zinc contents in the hair and fingernails (p<0.01, p<0.001, p<0.05, and p<0.01 respectively) and Zn/Cu ratio in the hair (p<0.01) of the diseased group were significantly lower than that of the healthy group.
Pathogenic factors of cardiovascular disease have three probabilities: (1) The iron contents of the diseased group were higher
than that of the healthy group in serum and lower in hair and fingernails (i.e., abnormal iron metabolism); (2) the zinc contents
and the Zn/Cu ratio of the diseased group were higher than that of the healthy group in the serum and the zinc contents in
the hair and fingernails and the Zn/Cu ratio in the hair of the diseased group were significantly lower than that of the healthy
group; (3) the chromium contents of the diseased group were significantly lower than that of the healthy group in the serum,
hair, and fingernails. 相似文献