Anthropological insights into the use of race/ethnicity to explore genetic contributions to disparities in health

Anthropological insights into the use of race/ethnicity to explore genetic contributions to disparities in health were developed using in-depth qualitative interviews with editorial staff from nineteen genetics journals, focusing on the methodological and conceptual mechanisms required to make race/ethnicity a genetic variable. As such, these analyses explore how and why race/ethnicity comes to be used in the context of genetic research, set against the background of continuing critiques from anthropology and related human sciences that focus on the social construction, structural correlates and limited genetic validity of racial/ethnic categories. The analyses demonstrate how these critiques have failed to engage geneticists, and how geneticists use a range of essentially cultural devices to protect and separate their use of race/ethnicity as a genetic construct from its use as a societal and social science resource. Given its multidisciplinary, biosocial nature and the cultural gaze of its ethnographic methodologies, anthropology is well placed to explore the cultural separation of science and society, and of natural and social science disciplines. Anthropological insights into the use of race/ethnicity to explore disparities in health suggest that moving beyond genetic explanations of innate difference might benefit from a more even-handed critique of how both the natural and social sciences tend to essentialize selective elements of race/ethnicity. Drawing on the example of HIV/AIDS, this paper demonstrates how public health has been undermined by the use of race/ethnicity as an analytical variable, both as a cipher for innate genetic differences in susceptibility and response to treatment, and in its use to identify 'core groups' at greater risk of becoming infected and infecting others. Clearly, a tendency for biological reductionism can place many biomedical issues beyond the scope of public health interventions, while socio-cultural essentialization has tended to stigmatize 'unhealthy behaviours' and the communities where these are more prevalent.     

Public attitudes towards psychiatry and psychiatric treatment at the beginning of the 21st century: a systematic review and meta‐analysis of population surveys

Public attitudes towards psychiatry are crucial determinants of help‐seeking for mental illness. It has been argued that psychiatry as a discipline enjoys low esteem among the public, and a “crisis” of psychiatry has been noted. We conducted a systematic review and meta‐analysis of population studies examining public attitudes towards various aspects of psychiatric care. Our search in PubMed, Web of Science, PsychINFO and bibliographies yielded 162 papers based on population surveys conducted since 2000 and published no later than 2015. We found that professional help for mental disorders generally enjoys high esteem. While general practitioners are the preferred source of help for depression, mental health professionals are the most trusted helpers for schizophrenia. If respondents have to rank sources of help, they tend to favor mental health professionals, while open questions yield results more favorable to general practitioners. Psychiatrists and psychologists/psychotherapists are equally recommended for the treatment of schizophrenia, while for depression psychologists/psychotherapists are more recommended, at least in Europe and America. Psychotherapy is consistently preferred over medication. Attitudes towards seeking help from psychiatrists or psychologists/psychotherapists as well as towards medication and psychotherapy have markedly improved over the last twenty‐five years. Biological concepts of mental illness are associated with stronger approval of psychiatric help, particularly medication. Self‐stigma and negative attitudes towards persons with mental illness decrease the likelihood of personally considering psychiatric help. In conclusion, the public readily recommends psychiatric help for the treatment of mental disorders. Psychotherapy is the most popular method of psychiatric treatment. A useful strategy to further improve the public image of psychiatry could be to stress that listening and understanding are at the core of psychiatric care.     

The role of the social sciences and economics in understanding and informing tree biosecurity policy and planning: a global summary and synthesis

Increased global biosecurity threats to trees, woods and forests have been strongly linked to the upsurge in worldwide trade and the expansion of tourism. A whole range of social, economic and political actors are implicated and affected by the movement of pests and diseases along these international pathways. A number of factors affect the actions of stakeholders, and wider public, including their values and motivations, how risks are perceived and acted upon, their ability to act, as well as the existing regulatory and economic environment. Understanding these factors is key to any future attempts to improve biosecurity policy and practice, and we present available evidence on six key dimension: (1) the role of different stakeholders and the broader public within tree health; (2) levels of knowledge and awareness of tree pests and diseases amongst the variety of end-user ‘stakeholder’ groups, and influences on their attitudes and practices; (3) social acceptability of management approaches; (4) the impact of formal and informal governance arrangements; (5) risk communication; (6) economic analyses on the impact of tree pests. We conclude by identifying evidence gaps and emphasising the need for better integration within the social sciences and between the social and natural sciences to promote effective interdisciplinary and policy-relevant contributions to tree health.     

Neuroinfections in developed versus developing countries

In recent supplement of neuroendocrinology letters, first time the authors from West and East, North and South of EU and the "Third World" present data on neuroinfections in high technology society - on nosocomial meningitis and vice versa in low technology and income countries of sub-Saharan Africa. 14 years survey of 171 cases of nosocomial paediatric meningitis is presented by Rudinsky et al. [1] and subpopulations of Acinetobacter baumannii and Pseudomonas aeruginosa [1,2] within last 20 years are briefly analyzed by Huttova et al. [2] and Ondrusova et al. [3]. All cases were complicating high technology procedures, such as neurosurgery, very low birth weight neonates after shunt implants etc. Current problems of management of nosocomial meningitis are reviewed by Bauer et al. [4] and consequence of inappropriate therapy by Huttova et al. [5]. Another high technology associated infection is septic embolisation followed by brain abscess and meningitis in patients with endocarditis after cardiac surgery (Kovac et al.) [6]. Experience from more than 600 cases is discussed in the article by Karvaj et al. [7] who outlines extremely high mortality in patients with endocarditis embolizing to central nervous system - up to 60%. The rest of papers are in contrary to problems of neuroinfections in EU and US focused on meningitis and cerebral malaria as commonest neuroinfections in the third world: 261 cases of cerebral malaria are discussed in a brief research note by Sudanese team of tropical programme in area of famine and civil war in southern Sudan (Bartkovjak and Ianetti et al.) [8]. Fungal neuroinfections complicating AIDS are of decreasing trend as reported by Njambi et al. from Kenya [9] and data from 497 cases from Uganda, Ethiopia and Burundi are presented by Benca et al. [10]. Finally an outbreak of meningococcal meningitis is reported by Benca et al. [11] from meningitis belt in Darfur and southern Sudan. We hope that the supplement may show difference in etiology, risk factors, therapy and outcome of neuroinfections (which is a burning public health and social problem in tropics) in other third world countries versus developed high-tech medical settings of US, EU and other high income countries, as presented by Benca et al. [12].     

COVID‐19 and the opportunities for research: The lockdowns’ impacts on wildlife,ecology and conservation biology,and the humanities

The ongoing lockdowns provide ideal conditions to study the relationship between wildlife and humans but among humans themselves. Subject Categories: Ecology, S&S: History & Philosophy of Science

Almost all research has been affected in some way or another by the COVID‐19 pandemic, at the very least by challenging collaboration and interaction. But some areas have been affected more than others. Ecology and conservation biology experience a real boon as ongoing lockdowns have presented unique opportunities to study the impact of human activities on animals and ecosystems. This has not just galvanised research but also promises to leave a legacy of networks and collaborations to explore means to reduce negative human impacts on biodiversity long after the pandemic has subsided. In the social sciences and humanities, however, the pandemic is raising fundamental questions about their ability to contribute meaningfully to inform policy and public health responses.

In the social sciences and humanities […] the pandemic is raising fundamental questions about their ability to contribute meaningfully to inform policy and public health responses.

     

Trauma and Humanitarian Translation in Liberia: The Tale of Open Mole

The focus of this paper is the intercultural process through which Open Mole and trauma-related mental illnesses are brought together in the postconflict mental health encounter. In this paper, I explore the historical dimension of this process by reviewing the history of Open Mole, and the ways in which it has been interpreted, acted on, and objectified by external observers over the last half-century. Moving into Liberia’s recent war and postconflict period, I examine the process by which Open Mole is transformed from a culture-bound disorder into a local idiom of trauma, and how it has become a gateway diagnosis of PTSD-related mental illnesses, and consider how it is produced as an objectified experience of psychiatric disorder in clinical humanitarian contexts. By studying how Open Mole is transformed in the humanitarian encounter, I address the structure and teleology of the humanitarian encounter and challenge some of the foundational assumptions about cultural sensitivity and community-based mental health care in postconflict settings that are prevalent in scholarship and practice today.     

Psychosocial interventions and the demoralization of humanitarianism

This paper critically analyses from a political sociology standpoint the international conceptualization of war-affected populations as traumatized and in need of therapeutic interventions. It argues for the importance of looking beyond the epidemiological literature to understand trauma responses globally. The paper explores how the imperative for international psychosocial programmes lies in developments within donor countries and debates in their humanitarian sectors over the efficacy of traditional aid responses. The aim of the paper is threefold. First, it discusses the emotional norms of donor states, highlighting the psychologizing of social issues and the cultural expectations of individual vulnerability. Second it examines the demoralization of humanitarianism in the 1990s and how this facilitated the rise of international psychosocial work and the psychologizing of war. Third, it draws attention to the limitations of a mental health model in Croatia, a country which has been receptive to international psychosocial programmes. Finally it concludes that the prevalent trauma approaches may inhibit recovery and argues for the need to re-moralize resilience.     

Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?

Significant extension of lifespan in important mammalian species is bound to attract the attention not only of the aging research community, but also the media and the wider public. Two recent papers published by Harrison et al. (2009) in Nature and by Colman et al. (2009) in Science report increased longevity of mice fed with rapamycin and of rhesus monkeys undergoing caloric restriction, respectively. These papers have generated considerable debate in the aging community. Here we assess what is new about these findings, how they fit with our knowledge of lifespan extension from other studies and what prospects this new work holds out for improvements in human longevity and human health span.     

Do Scientific Advancements Lean on the Shoulders of Giants? A Bibliometric Investigation of the Ortega Hypothesis

Background

In contrast to Newton''s well-known aphorism that he had been able “to see further only by standing on the shoulders of giants,” one attributes to the Spanish philosopher Ortega y Gasset the hypothesis saying that top-level research cannot be successful without a mass of medium researchers on which the top rests comparable to an iceberg.

Methodology/Principal Findings

The Ortega hypothesis predicts that highly-cited papers and medium-cited (or lowly-cited) papers would equally refer to papers with a medium impact. The Newton hypothesis would be supported if the top-level research more frequently cites previously highly-cited work than that medium-level research cites highly-cited work. Our analysis is based on (i) all articles and proceedings papers which were published in 2003 in the life sciences, health sciences, physical sciences, and social sciences, and (ii) all articles and proceeding papers which were cited within these publications. The results show that highly-cited work in all scientific fields more frequently cites previously highly-cited papers than that medium-cited work cites highly-cited work.

Conclusions/Significance

We demonstrate that papers contributing to the scientific progress in a field lean to a larger extent on previously important contributions than papers contributing little. These findings support the Newton hypothesis and call into question the Ortega hypothesis (given our usage of citation counts as a proxy for impact).     

Contribution of molecular techniques to the epidemiology of neotropical Leishmania species

Brand?o-Filho et al. and Oliveira et al. have recently reported the detection of Leishmania in sylvatic and synanthropic animals that were captured in areas of Brazil that are endemic for leishmaniasis. Such investigations raise the issue of reservoirs of important endemic diseases by using modern molecular biology and biochemical techniques that complement traditional methods. Ecoepidemiological studies focusing on possible reservoirs have been important for providing contributions to prophylaxis and control measures to be employed by public health authorities.     

Specifying cortical circuits: a role for cell lineage

Two recent papers, Li et al. (2012) in Nature and Ohtsuki et al. (2012) in this issue of Neuron, show that lineage relationships between cortical neurons impact the development of specific connectivity and functional properties of cortical circuits. However, several differences between their results highlight important questions for future investigation.     

Preventive Psychiatry: The Psychiatric Team as Consultant to the Public Health Nurse

Various forms of collaboration between the disciplines of public health and psychiatry are briefly reviewed and the 25-year-old mental health program of the Vancouver Health Department is described. The public health nurse has prime responsibility in all children with emotional disorders. She is supported by a psychiatric team which provides active treatment and educational and consultative help for the nurse and the school. During the year 1963, six social workers had 2357 contacts with nurses and school personnel but only 1049 treatment interviews. Of 401 children referred to the psychiatric team, 138 received active clinic treatment, 141 remained under supervision by the public health nurse, and 122 were referred elsewhere. In addition, 1330 children were identified as “mental hygiene cases” in the caseload of the 170 public health nurses in the community. By close co-ordination, the public health nurse and the psychiatric team can enhance each other''s contributions to community mental health.     

“Positive” Results Increase Down the Hierarchy of the Sciences

The hypothesis of a Hierarchy of the Sciences with physical sciences at the top, social sciences at the bottom, and biological sciences in-between is nearly 200 years old. This order is intuitive and reflected in many features of academic life, but whether it reflects the “hardness” of scientific research—i.e., the extent to which research questions and results are determined by data and theories as opposed to non-cognitive factors—is controversial. This study analysed 2434 papers published in all disciplines and that declared to have tested a hypothesis. It was determined how many papers reported a “positive” (full or partial) or “negative” support for the tested hypothesis. If the hierarchy hypothesis is correct, then researchers in “softer” sciences should have fewer constraints to their conscious and unconscious biases, and therefore report more positive outcomes. Results confirmed the predictions at all levels considered: discipline, domain and methodology broadly defined. Controlling for observed differences between pure and applied disciplines, and between papers testing one or several hypotheses, the odds of reporting a positive result were around 5 times higher among papers in the disciplines of Psychology and Psychiatry and Economics and Business compared to Space Science, 2.3 times higher in the domain of social sciences compared to the physical sciences, and 3.4 times higher in studies applying behavioural and social methodologies on people compared to physical and chemical studies on non-biological material. In all comparisons, biological studies had intermediate values. These results suggest that the nature of hypotheses tested and the logical and methodological rigour employed to test them vary systematically across disciplines and fields, depending on the complexity of the subject matter and possibly other factors (e.g., a field''s level of historical and/or intellectual development). On the other hand, these results support the scientific status of the social sciences against claims that they are completely subjective, by showing that, when they adopt a scientific approach to discovery, they differ from the natural sciences only by a matter of degree.     

Can social research paradigms justify the diversity of approaches to social life cycle assessment?

Purpose

The present paper aims to offer an explanation for the diversity of methodological approaches proposed up to the present for social life cycle assessment (sLCA), tracking down its roots in the cultural and scientific heritage of social sciences and especially management sciences. A second aim is to shift the current debate on methodologies to an epistemological level, presenting the first results of an ongoing critical review about which underlying paradigms have been applied in sLCA literature.

Methods

This paper moves from the hypothesis that the diversity of positions in philosophy of science and the “multiparadigmatic” character of social sciences have had repercussions on sLCA literature since its beginnings, probably in an unconscious manner. Therefore, a discriminating reflection on the scientific and disciplinary inheritance that can represent the roots of sLCA has been conducted. The philosophy of science and the role of different research paradigms in social sciences have been deepened to provide an overview of the main elements of a paradigm (in terms of ontology, epistemology, and methodology). Finally, a brief but critical review of 133 selected scientific contributions on sLCA has been conducted to highlight which paradigms have been applied in sLCA studies.

Results and discussion

Recognizing that boundaries between paradigms are subtle and that researchers are rarely conscious of which paradigm underpins their works, a distinction between the interpretivist and post-positivist approaches used by the studies has been carried out on the basis of a text analysis conducted by identifying the main “literal” criteria. From an initial population of 209 studies, we excluded those concerning reviews of sLCA literature and those with selected criteria that were insufficient to catch the epistemological viewpoint of the authors. Among the remaining papers (133), 73 % has been ascribed to the group of interpretivism-oriented paradigms and only 24 % could be ascribed to the post-positivist one; the remaining 3 % is represented by studies with both characteristics. This data deserves some attention because, since the beginnings of sLCA methodologies, most sLCA publications explicitly suggest having the same underlying perspectives as environmental life cycle assessment (eLCA).

Conclusions

In light of the reflections carried out, we argue that it is important, before going into methodological questioning issues, to be aware of which paradigm is underlying. Indeed, in this phase of sLCA development, scholars should go beyond the simple methodological debate and recognize the “multilayered” nature of social phenomena and the multiparadigmatic characteristics of social and management sciences.

     

Public health ethics: asylum seekers and the case for political action

This paper is a case study in public health ethics. It considers whether there is a basis in ethics for political action by health professionals and their associations in response to inhumane treatment. The issue arises from Australia's treatment of asylum seekers and the charge that this treatment has been both immoral and inhumane. This judgement raises several questions of broader significance in bioethics and of significance to the emerging field of public health ethics. These questions relate to the role of health professionals in response to inhumane treatment of people in their charge; to the discipline of public health in light of a growing recognition of its ethical basis; and the role of public health and bioethical associations in response to ethical issues arising in a political context. It is argued that, in serious cases of humanitarian and human rights abuses affecting health and well-being, there is a case for political action by health professionals, academic and professional institutions, and associations of public health and ethics.     

What to Do with Race? Changing Notions of Race in the Social Sciences

The Supplement to the Surgeon General's Report on Mental Health documents that race, ethnicity, and culture are linked to the use of mental health services and the receipt of quality mental health care. The Supplement provides an elaborate discussion on how culture affects mental health care without a corresponding level of discourse on race. How race is handled in the Supplement suggests that it is still a sensitive topic and one that is difficult to address in a public report. This sensitivity parallels the difficulties that the social sciences have had in investigating issues of race. In this paper, we highlight some perspectives that have influenced the way race has been studied in the past and how these views reflect the general political climates of the eras that produced them.     

A festschrift for Jeremy B.C. Jackson and his integration of paleobiology, ecology, evolution, and conservation biology

This collection of papers is dedicated to the career and achievements of Dr. Jeremy B.C. Jackson, and is written by a sample of his students, post-docs, and colleagues over his career. Jackson is an influential leader in cross-disciplinary research integrating ecology and paleontology. His contributions are broad in scope, and range in topic from the ecological and evolutionary consequences of the formation of the Central American Isthmus to the long-term impacts of human activities on the oceans. Two areas of particular interest have been the evolutionary ecology of coral reef organisms and the tempo and mode of speciation in the sea. Papers in the collection examine: colonial marine animals (Buss and Rice, Lidgard et al.), marrying genes and fossils (Budd et al., Marko and Hart, Palumbi et al., Jagadeeshan and O’Dea), the geography, tempo, and mode of evolution (Bromfield and Pandolfi, Norris and Hull, Vermeij, Erwin and Tweedt), and marine ecosystem health (Sandin and Sala).