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The 13C.n.m.r spectra of water-soluble and -insoluble glucans synthesized by enzymes isolated from six strains of Streptococcus mutans are interpreted. The glucans are shown to be composed primarily of α(1→3)- and α-(1→6)-linked glucosyl residues, and the relative abundance of each linkage is estimated from peak areas. Treatment of water-insoluble glucans with dextranase is found to result in water-soluble and -insoluble products, the former enriched in α-(1→6)-linkages and the latter in α-(1→3)-linkages. The structural conclusions arrived at by 13C-n.m.r. spectroscopy are consistent with data from methylation analysis and 1H-n.m.r. spectroscopy. 相似文献
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Rodrigo Rico-Gómez Ezequiel P. de Inestrosa-Villatoro Juan Manuel López-Romero Francisco Nájera Rafael López-Corpas 《Nucleosides, nucleotides & nucleic acids》2013,32(7-8):1411-1421
Abstract The synthesis of two 7-glycosyl-6-thiotheophylline nucleosides where the sugar moieties are β-D-glucose (1b) and α-D-arabinose (2b) is reported. The syn-anti equilibrium of the peracetyl derivatives was studied by the line-shape and the 1H-NMR nOe methods, and molecular mechanics analysis. 相似文献
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血管紧张素-(1-7)[angiotensin(1-7), Ang-(1-7) ]是肾素-血管紧张素系 统(renin-angiotensin system, RAS)的新成员之一. 与血管紧张素Ⅱ(Ang Ⅱ)比 较,Ang-(1-7)在高血压及动脉粥样硬化等疾病中发挥着心血管保护作用. 最新研究 发现,Ang-(1-7)在平滑肌细胞增殖及迁移、内皮细胞功能、脂质代谢的这些动脉粥样硬化相关病理发展过程中起着重要作用,能够抑制动脉粥样硬化斑块的形成及加强斑块的稳定性. 本文就Ang-(1-7)与动脉粥样硬化疾病相关的最新研究进展进行综述,讨论Ang-(1-7)在动脉粥样硬化中的作用机制,也为Ang-(1-7)相关的ACE2/Ang -(1-7)/Mas轴作为未来临床治疗途径提供思路. 相似文献
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实验采用兔外周动脉离体标本,在预收缩血管后,用血管紧张素[angiotensin-(1-7),Ang-(1-7)]舒张血管,比较Ang-(1-7)对外周各血管床的舒张效应并分析其产生机制。结果显示:(1)Ang-(1-7)可剂量依赖性舒张血管,但舒张作用有所不同;(2)Ang-(1-7)的舒张作用在很大程度上依赖于内皮的NO系统;(3)Ang-(1-7)的舒张血管效应不通过AT1和AT2受体。上述结果提示:Ang-(1-7)可能作用于内皮上的非AT1和AT2受体,通过调节NO释放而起舒血管作用。 相似文献