共查询到20条相似文献,搜索用时 15 毫秒
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Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO 总被引:24,自引:8,他引:16 下载免费PDF全文
Vania Gelmetti Jinsong Zhang Mirco Fanelli Saverio Minucci Pier Giuseppe Pelicci Mitchell A. Lazar 《Molecular and cellular biology》1998,18(12):7185-7191
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Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex 下载免费PDF全文
Nickolai A. Barlev Vladimir Poltoratsky Tom Owen-Hughes Carol Ying Lin Liu Jerry L. Workman Shelley L. Berger 《Molecular and cellular biology》1998,18(3):1349-1358
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Lalit Ponnala Anne-Marie Stomp Donald L Bitzer Mladen A Vouk 《EURASIP Journal on Bioinformatics and Systems Biology》2006,2006(1):23613-9
A decoding algorithm is tested that mechanistically models the progressive alignments that arise as the mRNA moves past the rRNA tail during translation elongation. Each of these alignments provides an opportunity for hybridization between the single-stranded, -terminal nucleotides of the 16S rRNA and the spatially accessible window of mRNA sequence, from which a free energy value can be calculated. Using this algorithm we show that a periodic, energetic pattern of frequency 1/3 is revealed. This periodic signal exists in the majority of coding regions of eubacterial genes, but not in the non-coding regions encoding the 16S and 23S rRNAs. Signal analysis reveals that the population of coding regions of each bacterial species has a mean phase that is correlated in a statistically significant way with species () content. These results suggest that the periodic signal could function as a synchronization signal for the maintenance of reading frame and that codon usage provides a mechanism for manipulation of signal phase.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32] 相似文献
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RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein 总被引:1,自引:1,他引:0 下载免费PDF全文
Dorjbal Dorjsuren Yong Lin Wenxiang Wei Tatsuya Yamashita Takahiro Nomura Naoyuki Hayashi Seishi Murakami 《Molecular and cellular biology》1998,18(12):7546-7555
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Francesco Fabris Andrea Sgarro Alessandro Tossi 《EURASIP Journal on Bioinformatics and Systems Biology》2007,2007(1):31450
Mathematical tools developed in the context of Shannon information theory were used to analyze the meaning of the BLOSUM score, which was split into three components termed as the BLOSUM spectrum (or BLOSpectrum). These relate respectively to the sequence convergence (the stochastic similarity of the two protein sequences), to the background frequency divergence (typicality of the amino acid probability distribution in each sequence), and to the target frequency divergence (compliance of the amino acid variations between the two sequences to the protein model implicit in the BLOCKS database). This treatment sharpens the protein sequence comparison, providing a rationale for the biological significance of the obtained score, and helps to identify weakly related sequences. Moreover, the BLOSpectrum can guide the choice of the most appropriate scoring matrix, tailoring it to the evolutionary divergence associated with the two sequences, or indicate if a compositionally adjusted matrix could perform better.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29] 相似文献
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Shu-Qin Zhang Morihiro Hayashida Tatsuya Akutsu Wai-Ki Ching Michael K Ng 《EURASIP Journal on Bioinformatics and Systems Biology》2007,2007(1):20180
A Boolean network is a model used to study the interactions between different genes in genetic regulatory networks. In this paper, we present several algorithms using gene ordering and feedback vertex sets to identify singleton attractors and small attractors in Boolean networks. We analyze the average case time complexities of some of the proposed algorithms. For instance, it is shown that the outdegree-based ordering algorithm for finding singleton attractors works in time for , which is much faster than the naive time algorithm, where is the number of genes and is the maximum indegree. We performed extensive computational experiments on these algorithms, which resulted in good agreement with theoretical results. In contrast, we give a simple and complete proof for showing that finding an attractor with the shortest period is NP-hard.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32] 相似文献
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Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2 总被引:19,自引:5,他引:14 下载免费PDF全文
Kim M. Lonergan Othon Iliopoulos Michael Ohh Takumi Kamura Ronald C. Conaway Joan Weliky Conaway William G. Kaelin Jr. 《Molecular and cellular biology》1998,18(2):732-741
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Characterization of SRp46, a Novel Human SR Splicing Factor Encoded by a PR264/SC35 Retropseudogene 总被引:2,自引:0,他引:2 下载免费PDF全文
Johann Soret Renata Gattoni Ccile Guyon Alain Sureau Michel Popielarz Erwann Le Rouzic Stphanie Dumon Franoise Apiou Bernard Dutrillaux Hartmut Voss Wilhelm Ansorge James Stvenin Bernard Perbal 《Molecular and cellular biology》1998,18(8):4924-4934
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Thomas Farkas Yulia A. Kutskova Vincenzo Zimarino 《Molecular and cellular biology》1998,18(2):906-918