APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

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Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway

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SPT6 functions in transcriptional pause/release via PAF1C recruitment

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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

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The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint

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Highlights

• •Chemical proteomics in G₁ cells treated with small molecule APC/C inhibitors reveals novel putative APC/C substrates.
• •The insulin receptor adaptor IRS2 is an APC/C substrate that is targeted for degradation by APC/C^Cdh1.
• •Quantitative proteomics in IRS2 knockout cells reveals a deficiency in cell cycle related protein expression.
• •IRS2 promotes a robust spindle assembly checkpoint (SAC) during M-phase.

     

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

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Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria

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Structural and Functional Analyses of the FAM46C/Plk4 Complex

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In vivo 2H/13C flux analysis in metabolism research

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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture,phosphorylation, and ubiquitylation

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Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

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POGZ suppresses 2C transcriptional program and retrotransposable elements

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Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity

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Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD

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Methylotrophs: from C1 compounds to food

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The respiratory supercomplex from C. glutamicum

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An acentriolar centrosome at the C. elegans ciliary base

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