Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes

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Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

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Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial

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Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

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Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial

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Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance

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TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease

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CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

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SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2

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Inhibition of ATP-citrate lyase improves NASH,liver fibrosis,and dyslipidemia

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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes

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A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage

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Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial

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Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity

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Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity

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