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We present an inquiry-based curriculum based on the digital evolution platform Avida-ED (http://avida-ed.msu.edu). We designed an instructional sequence and lab book consisting of an introduction to Avida-ED and a set of three lessons focused on specific evolutionary concepts. These served to familiarize students with experimental evolution and Avida-ED. Students then developed independent Avida-ED research projects to test their own questions. Curriculum design and implementation occurred over the course or two semesters, with a pilot implementation in the first semester, followed by curriculum revision and full implementation in the second semester. The curriculum was implemented in an undergraduate Introductory Cell and Molecular Biology course at a major research university. Full implementation of the curriculum in semester two involved the use of Avida-ED mainly in the teaching lab in parallel with a bacterial antibiotic resistance experimental research stream, allowing students to draw connections between Avidian digital evolution and the evolution of antibiotic resistance in microbial populations. After carrying out the introductory exercises, students developed independent Avida-ED projects to test their own research questions, and presented their data to researchers in the NSF-funded BEACON Center for the Study of Evolution in Action. Preliminary results of our studies to assess the impacts of an Avida-ED curriculum indicate a positive effect on student learning of evolutionary concepts, particularly in increasing the level of complexity of student explanations about the random nature of mutation. 相似文献
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Silverthorn DU 《Advances in physiology education》2003,27(1-4):91-96
The National Research Council-sponsored report, BIO 2010: Transforming Undergraduate Education for Future Research Biologists, describes a number of significant changes that should be made to the undergraduate biology curriculum if we are to adequately train students to become the researchers of the 21st century. What should be of concern to the physiology community is the lack of identifiable physiology in the proposed revisions. This article describes the report and suggests some steps that physiologists can take to enhance our discipline in the undergraduate biology curriculum. 相似文献
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Hongqing Cao Francisco J. Romero-Campero Stephan Heeb Miguel Cámara Natalio Krasnogor 《Systems and synthetic biology》2010,4(1):55-84
This paper proposes a new methodology for the automated design of cell models for systems and synthetic biology. Our modelling
framework is based on P systems, a discrete, stochastic and modular formal modelling language. The automated design of biological
models comprising the optimization of the model structure and its stochastic kinetic constants is performed using an evolutionary
algorithm. The evolutionary algorithm evolves model structures by combining different modules taken from a predefined module
library and then it fine-tunes the associated stochastic kinetic constants. We investigate four alternative objective functions
for the fitness calculation within the evolutionary algorithm: (1) equally weighted sum method, (2) normalization method,
(3) randomly weighted sum method, and (4) equally weighted product method. The effectiveness of the methodology is tested
on four case studies of increasing complexity including negative and positive autoregulation as well as two gene networks
implementing a pulse generator and a bandwidth detector. We provide a systematic analysis of the evolutionary algorithm’s
results as well as of the resulting evolved cell models. 相似文献
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Methods to visualize, track, measure and perturb proteins in living cells are central to biomedicine's efforts to characterize and understand the spatial and temporal underpinnings of life inside cells. Although fluorescent proteins have revolutionized such studies, they have shortcomings, which have spurred the creation of alternative approaches to chemically label proteins in live cells. In this review we highlight research questions that can be addressed using site-specific chemical labeling and present a comparison of the various labeling techniques that have been developed. We also provide a 'roadmap' for selection of appropriate labeling techniques(s) and outline generalized strategies to validate and troubleshoot chemical labeling experiments. 相似文献
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Slack JM 《The International journal of developmental biology》2003,47(2-3):99-104
The undergraduate curriculum for bioscience degrees at the University of Bath is outlined, and the place is described of the developmental biology components within it. In the first year, all students receive four lectures on animal development and four on plant development. In the second year, many choose substantial lecture and practical courses on animal development, which outline the early development of Xenopus, mouse and Drosophila. The third year is usually spent on placement, with a company or research institute, a few of which are developmental biology-based, and may also involve some distance learning. The fourth year is spent back in Bath. Students interested in developmental biology can opt for advanced courses covering vertebrate organogenesis, developmental neurobiology and plant development. There are also one-semester, final-year projects spent in the labs of faculty members, several of whom specialise in developmental biology and offer projects accordingly. 相似文献
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Training for bioinformatics and computational biology 总被引:1,自引:0,他引:1
Pearson WR 《Bioinformatics (Oxford, England)》2001,17(9):761-762
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Schulze-Kremer S 《In silico biology》2002,2(3):179-193
About five years ago, ontology was almost unknown in bioinformatics, even more so in molecular biology. Nowadays, many bioinformatics articles mention it in connection with text mining, data integration or as a metaphysical cure for problems in standardisation of nomenclature and other applications. This article attempts to give an account of what concept ontologies in the domain of biology and bioinformatics are; what they are not; how they can be constructed; how they can be used; and some fallacies and pitfalls creators and users should be aware of. 相似文献
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《生物信息学》本科教学初探 总被引:2,自引:0,他引:2
针对生物信息学本科教学中的教学方法、实验教学、考核办法以及如何与现代教育技术相结合进行了初步的探索,并对如何提高教学效果培养跨学科的生物信息学人才做了深入思考。 相似文献
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Evolving strategies for enzyme engineering 总被引:18,自引:0,他引:18
Bloom JD Meyer MM Meinhold P Otey CR MacMillan D Arnold FH 《Current opinion in structural biology》2005,15(4):447-452
Directed evolution is a common technique to engineer enzymes for a diverse set of applications. Structural information and an understanding of how proteins respond to mutation and recombination are being used to develop improved directed evolution strategies by increasing the probability that mutant sequences have the desired properties. Strategies that target mutagenesis to particular regions of a protein or use recombination to introduce large sequence changes can complement full-gene random mutagenesis and pave the way to achieving ever more ambitious enzyme engineering goals. 相似文献
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Michael Primig 《生物化学与生物物理学报:疾病的分子基础》2012,1822(12):1880-1895
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The enormous amount of information available in cell biology has created a challenge in selecting the core concepts we should be teaching our undergraduates. One way to define a set of essential core ideas in cell biology is to analyze what a specific cell biology community is teaching their students. Our main objective was to analyze the cell biology content currently being taught in Brazilian universities. We collected the syllabi of cell biology courses from public universities in Brazil and analyzed the frequency of cell biology topics in each course. We also compared the Brazilian data with the contents of a major cell biology textbook. Our analysis showed that while some cell biology topics such as plasma membrane and cytoskeleton was present in ~100% of the Brazilian curricula analyzed others such as cell signaling and cell differentiation were present in only ~35%. The average cell biology content taught in the Brazilian universities is quite different from what is presented in the textbook. We discuss several possible explanations for these observations. We also suggest a list with essential cell biology topics for any biological or biomedical undergraduate course. The comparative discussion of cell biology topics presented here could be valuable in other educational contexts. 相似文献
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Membrane transport is a fundamental concept that undergraduate students of cell biology understand better with laboratory experience. Formal teaching exercises commonly used to illustrate this concept are unbiological, qualitative, or intricate and time consuming to prepare. We have developed an exercise that uses uptake of radiolabeled nutrient analogues by attachment-dependent animal cells cultured on multiwell trays. This system can readily be manipulated within a typical 3-h laboratory period to yield reproducible, biologically relevant, quantitative data regarding key aspects of membrane transport. Each 24-well tray of cultures allows a group of two to four students to compare eight conditions in triplicate. If different groups of students test different conditions or different types of cells, data can be shared for an even broader experience. The exercise is also readily adaptable for open-ended student projects. Here we illustrate the exercise measuring uptake of the nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose. Students successfully tested the effects of competing sugars, putative inhibitors of the GLUT1 transporter, and changes in cell physiology that might be expected to affect glucose transport in epithelial cells and fibroblasts. In this exercise students find the nutritional and medical implications of glucose transport and its regulation intriguing. They also learn to handle radioisotopes and cultured cells. 相似文献
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V. D. Lakhno 《Biophysics》2011,56(6):1047-1054
Mathematical biology and bioinformatics represent a new and rapidly progressing line of investigations which emerged in the
course of work on the project “Human Genome”. The main applied problems of these sciences are drug design, patient-specific
medicine and nanobioelectronics. It is shown that progress in the technology of mass sequencing of the human genome has set
the stage for starting the national program on patient-specific medicine. 相似文献