Three New Steroidal Alkaloids from Pachysandra axillaris

This paper describes the chemical structure elucidation of the three new alkaloids isolated from Pachysandra axillarls Franch. They are pachysamine G (20α-dimethylamino-3β-tigloylamino-5α-pregnane), pachysamine H (20α-dimethylamino-3α-N-methyl, benzoylamino-5α-pregnane) and pachysanaximine A (20 α-dimethylamino-3β-methylamino-4β-benzoxyl-5α-pregnane) respectively. Other two compounds were identified as Pachysamine A, B.     

Studies on Chemical Constituents of Fritillaria yuminensis

Six compounds were isolated from the bulbs of Fritillaria yuminensis X. Z. Duan. They were elucidated as 5α, 14α-cevanine-3α-hydroxy-6-one ( Ⅰ ), 5α, 14α-cevanine-3-one-6β-O-β-D-glucoside ( Ⅱ ), imperialine ( Ⅲ ), delavinone ( Ⅳ ), tortifolisine ( Ⅴ ) and adenosine( Ⅵ ) by means of spectral analysis and chemical reaction. They all were firstly isolated from this plant. Among them, compound Ⅰ and Ⅱ, named yubeinine and yubeiside respectively, were new compounds.     

The Glucosides from Swertia mussotii Franch

Swertia mussotii Franch. is a herb used for treatment of liver disease in Qinghai-Tibcran Plateau folk. Further investigation on chemical constituents in aqueous extract of Swertia mussotii Franch. has been reported here. Seven compounds (Ⅰ, Ⅲ–Ⅷ) were achieved except mangiferin (Ⅱ) isolated previously by a chromatograph. They belong in secoiridoids, flavonoids and xanthonoids, respectively. The structures of known compounds were identified as amarogentin(Ⅲ), swertisin(Ⅷ), 8-O-β-D-glucopyranosyl-1, 3, 5-trihydroxyxanthone(Ⅶ) and 8-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosyl)-I, 7-dihydroxy-3-methoxyxanthone (Ⅵ). The structures of other three new compounds have been elucidated as 7-O-β-D-xylopy-ranosyl-1, 8-dihydroxy-3-methoxyxanthone (Ⅳ), 7-O-[α-L-rhamnopyranosyl- (1-2)-β-D-xylopyranosyl]-l,8-dihydroxy-3-methoxyxanthone(Ⅰ)and 3-O-β-D-glucopyranosy 1,8-dihydroxy-5-methoxyxanthone (Ⅴ), by means of the chemical and spectral methods. Mangiferin, amarogentin and 7-0- [α-L-rhamnopyranosyl-(1-2)-β-D-xylopyranosyl]-l,8-dihydroxy-3-methoxyxanthone are the principal glucosides in this plant.     

Studies on the Chemical Constituents of Rourea microphylla (Hook. et Arn) Planch.

Eleven compounds were isolated from the twigs and leaves of Rourea microphylla (Hook. et Arn) Planch. They were identified as quercetin-3-O-α-L-rhamnopyranoside (Ⅰ), hyperin (Ⅱ), quercetin (Ⅲ), astilbin (Ⅳ), β-sitosterol (Ⅴ), β-sitosteryl-β-D-glucopyranoside (Ⅵ), physcion (Ⅶ), erythroglaucin (Ⅷ), stearic acid (Ⅸ), palmitic acid (Ⅹ) and n-nonacosanane (Ⅺ) respectively, by means of UV, IR, NMR, MS spectra analyses and through chemical methods. The compounds Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅵ, Ⅶ, Ⅷ, Ⅸ, Ⅹ and Ⅺ were first reportedin the Rourea genus.     

Isolation and Indentification of Protosaponins from Fresh Rhizomes of Dioscorea zingiberensis Wright

Five steroidal chemical compounds were isolated from the fresh rhizomes of Dioseorea zingiberensis Wright gathered from Sichuan Province. Their chem ieal structures have been elucidated as diosgenin palmitate [Ⅰ]; β-sitosterol [Ⅱ]; gra- cillin [Ⅲ]; protogracillin [Ⅳ] and 3-O-{α-L-rhamnopyranosyl (1→3)-[β-D-glucopy- ranosyl (1→2)]-β-D-glucopyranosyl}-26-O-{β-D-glucopyranosyl}-diosgenin [Ⅴ]. [Ⅴ]is a new steroidal saponin, named protozingiberensissaponin.     

中越猕猴桃根化学成分研究

用溶剂提取和硅胶柱层析分离的方法 ,从中越猕猴桃 (Actinidiaindochinensis)的根部分分离得到 6个化合物 ,根据其理化性质和波谱分析 ,分别鉴定为 :2α,3α,2 4 三羟基 1 2 烯 2 8 齐墩果酸 (Ⅰ ) ,2α,3α 二羟基 1 2 烯 2 8 乌苏酸 (Ⅱ ) ,2α,3α ,1 9α 三羟基 1 2 烯 2 8 乌苏酸 (Ⅲ ) ,熊果酸 (Ⅳ ) ,β 谷甾醇 (Ⅴ ) ,和 β 胡萝卜甙(Ⅵ )。化合物Ⅰ、Ⅱ、Ⅲ、Ⅵ为首次从该植物中获得。其中化合物Ⅰ、Ⅱ为首次从该属植物获得。     

贵州紫云产黄花香茶菜的化学成分研究

采用甲醇回流提取和硅胶柱层析方法,从紫云产黄花香茶菜中分离得到6个化合物,结合1H-NMR、13C-NMR数据及文献资料鉴定为黄花香茶菜乙素(Ⅰ)、黄花香茶菜丁素(Ⅱ)、大萼变型香茶菜甲素(Ⅲ)、3β-Hydroxy-18α,19α-urs-20-en-28-oic acid(Ⅳ)、齐墩果酸(Ⅴ)和熊果酸(Ⅵ)。其中化合物Ⅳ为首次从该属植物中分离得到。     

青蕨化学成分的研究

从青蕨的乙酸乙酯提取物中分离得到6个化合物,通过化学方法及波谱分析,分别将其结构鉴定为木香素Ⅲ(1),7-甲氧基鬼灯擎素(2),扶桑甾醇(3),5-(3′-甲基丁基)-8-甲氧基呋喃香豆素(4),2-(3′-羟基-3′-甲基)丁基-4-羟基-5-甲氧基苯酚-1-O-β-D匍吡喃糖苷(青蕨素Ⅰ)(5)和2-(3′-羟基-3′-甲基)丁基-4-羟基-3,6-二甲氧基苯酚-1-O-β-D-匍吡喃糖苷(青蕨素Ⅱ)(6)。化合物5和6为新化合物,化合物1,2,3和4为首次从该植物中分离得到。     

Isolation and Indentification of Steroidal Saponins from Dioscorea zingiberensis Wright

Four known steroidal compounds were isolated from the rhizomes of Dioscorea zingiberensis Wright gathered from Hubei Province. Their structures were identified by means of spectroscopic analyses as Epi-smilagenin[Ⅰ]; 3-O-(β-D glucopyranosyl) diosgenin[Ⅱ]; 3-O-[β-D-glucopyranosyl (1→ 4)-β-D-glucopyranosyl-diosgenin[Ⅲ]; 3-O {β-D glucopyranosyl (1→ 3)-[α-L-rhamnopyranosyl (1 →2)]-β-D glucopyranosyl} diosgenin [Ⅳ].     

蒲葵叶化学成分研究

为研究传统药用植物蒲葵的化学成分,从蒲葵叶中分离得到5个化合物,分别鉴定为:3,5,7-三羟基-4′甲氧基黄酮醇(Ⅰ)、5,7,4′-三羟基黄酮-8-C-D-葡萄糖苷(Ⅱ)、β-谷甾醇(Ⅲ)、豆甾醇(Ⅳ)、二十六烷醇(Ⅴ)。该5个已知化合物均为首次从蒲葵叶中分离得到。     

亮叶杨桐(石芽茶)中黄酮类成分的研究

从广西产亮叶杨桐(Adinandra nitida Merr.ex H.L.Li)中,分得三种黄酮类成分:Ⅰ、Ⅱ和Ⅲ。经IR、UV(位移诊断)、熔点、混熔点、薄层层析鉴定:Ⅰ为芹菜素(Apigenin);Ⅱ为芹菜素-5-0-α-L-吡喃鼠李糖基(1→4-6~(?)-乙酰基-β-D-吡喃葡萄糖吡;Ⅲ为芹菜素-5-0-α-L-吡喃鼠李糖基(1→4)-β-D-吡喃葡萄糖甙。     

Structures of Sarcorucinine D and Pachyaximine A,B

In this paper, three new alkaloids, sarcorucinine D (1), and paehyaximine A, B (2, 3) were isolated from Sarcococca ruscifolia Stapf and Pachysandra axillaris Franch, respectively. The structures of sarcorucinine D (1) and pachyaximine A, B (2, 3) were elucidated to be 3β-hydroxyl-20α-dimethylamino-5α-pregnane (1); and 3β-methoxyl-20α-dimethylamino-pregne-5-ne (2); and 3β-methoxyl-16-hydroxyl-20α-dimethylaminopregne-5-ne (16-hydroxyl-pachyaxi- mine A) (3), respectively.     

The Chemical Constituents of Elsholtzia ciliata (Thund.) Hyland

Fourteen compounds have been obtained from the Elsholtzia ciliata (Thund.) Hyland. Their structures were identified by spectral and chemical methods as following: Ⅰ. 6-methyl-tritriacontane, Ⅱ. 13-cyclohexyl-hexoacosane, Ⅲ. β-sitosterol, Ⅳa. palmitic acid, Ⅳb. linoleic acid, Ⅳc. linolenic acid, Ⅴ. ursolic acid, Ⅵ. 5-hydroxy--6, 7-dimethoxyflavone, Ⅶ. 5-hyd-foxy-7, 8-dimethoxyflavone, Ⅷ. 5,7-dihydroxy-4'-methoxyflavone, Ⅸ. 5-hydroxy-7,4'-dime-thoxyflavone, Ⅹ.β-sitosterol-β-D-glucoside, Ⅺ. 5-hydroxy-6-methylflavanone-7-O-α-D-galacopy-ranoside, Ⅻ. acacetin-7-O-β-glucoside. Among all the compounds, Ⅺ is a new compound. Except for Ⅳb and Ⅳc, the other twelve compounds were first found in this plant.     

丽江蚤缀的化学成分

利用DiaionHP20及硅胶柱层析进行化合物的分离,从乙酸乙酯萃取部位分离得到了8个化合物,借助多种光谱技术进行结构鉴定分别鉴定为E对甲氧基肉桂酸(pEMethoxycinnamicacid)(Ⅰ),Z对甲氧基肉桂酸甲酯(3(4Methoxyphenyl)2Zpropenoicacidmethylester)(Ⅱ),Z对甲氧基肉桂酸(pZMethoxycinnamicacid)(Ⅲ),E对羟基肉桂酸甲酯(pEHedroxycinnamicacidmethylester)(Ⅳ),2,4,6,4′fourhydroxydihydrochalcone(Ⅴ),5,7,4′三羟基3′,5′二甲氧基黄酮(Ⅵ),β谷甾醇(βSidosterol)(Ⅶ),胡萝卜苷(Daucosterol)(Ⅷ)。所有化合物均为已知化合物,并首次从该植物中分得。     

The Chemical Constituents from Cynanchum Komarovii Al. Ilinski

Ten compounds were isolated from the roots and stems of Cynanchum komarovii Al. Iljinski. They were identified as 7-demethoxylophorine (Ⅰ), epi-alnusenol (Ⅱ), β-sitosterol (Ⅲ), triacontanolic acid (Ⅳ), sucrose (Ⅴ), desoxytylophorinin N-oxide (Ⅵ), apocynine (Ⅶ), paeonol (Ⅷ), β-sitosteryl-β-D-glucopyranoside (Ⅸ) and glucose (Ⅹ) by means of UV, IR, NMR, MS spectral analyses and through chemical methods. These compounds were first reported in this plant. One of them, Ⅵ is a new alkaloid. The bioassay results showed that the compounds Ⅰ, Ⅵ and reaction product Ⅺ exhibited cytotoxic effects to P-388 leukemia cell in vitro. Ⅺ is also a new compound.     

中药茅莓化学成分研究

用溶剂提取和硅胶柱层析分离的方法 ,根据光谱分析鉴定中药茅莓的结构 ,分离并鉴定了 5个化合物 ,分别为β 谷甾醇 (Ⅰ )、蔷薇酸 (Ⅱ )、2α,3α,1 9α,2 3 tetrahydroxyurs 1 2 en 2 8 oicacid(Ⅲ )、β 葫萝卜甙 (Ⅳ )和悬钩子皂甙 (Ⅴ ) ,以上前四个化合物均为首次从该植物中分得     

Study on Chemical Constituents of Gentianopsis barbata var. Stennocalyx H. W. Li ex T.N. Ho

Nine compounds were isolated from Gentianopsis barbata var. stennocalyx H. W. Li ex. T.N.Ho. Their structures are identified as 1-hydroxy4, 7, 8-trimethoxyxanthone (Ⅰ), 1, 7-dihydroxy-3, 8-dimethoxyxanthone (Ⅱ), 1, 7, 8-trihydroxy-3-methoxyxanthone (Ⅲ), 1-O-(β-D- xylopyranosyl-(1→6)-β-D-glucopyranosyl)-3, 7, 8-trimethoxyxanthone (Ⅳ), 1-O-(β-D-xylopy- ranosyl- (1→6)-β-D-glucopyranosyl)-7-hydroxy-3, 8-dimethoxyxanthone (Ⅴ), 1-O-(β-D-xylo- pyranosyl-(1→6)-β-D-glucopyranosyl)-7, 8-dihydroxy-3-methoxyxanthone (Ⅵ), luteolin-7-O- β-D-glucoside (Ⅶ), oleanolic acid (Ⅷ) and ursolic acid (Ⅸ) by means of chemical methods and UV, IR and NMR determinations respectively.     

The Chemical Principles from the Female lnftorescences of Typha angustata

Seven crystalline compounds have been isolated from the female inflorescences of Typha angustata Bory et Chaub. They were identified as vanillic acid (Ⅰ), E-p-hydroxy- cinnamic acid (Ⅱ), Protocatechuic acid (Ⅲ), E-Pro-penoic acid-3- (4-hydroxyphenyl)- 2,3-dihydrohypropyl ester (Ⅳ), Succinic acid (Ⅴ), p-hydroxybenzaldehyde (Ⅵ) and D-mannitol (Ⅶ). (Ⅳ) is a new compound. (Ⅰ), (Ⅱ), (Ⅲ) and (Ⅶ) were attained for the first time from Typhaceae.     

Study on the Chemical Constituents of Comastoma pulmonarium (Turcz.) Toyohuni

Eight compounds were isolated from Comastoma pulmonarium (Gentianaceae). Theirstructures are identified as1,8-dihydroxy-3,5-dimethoxyxanthone(Ⅰ),1,8-dihydroxy-3,7-dimetho-xyxanthone(Ⅱ), 1-hydroxy-3,7,8-trimethoxyxanthone(Ⅲ),8-hydroxy-l,3,5-trimethoxyxanthone(Ⅳ), 1,3,8-trihydroxy-7-methoxyxanthone(Ⅴ), 1-O-β-D-glucopyranosyl-3,8-dihydroxy-7-methxy-xanthone(Ⅵ), oleanolic acid(Ⅶ) and swertisin(Ⅷ) by means of chemical methods andUV, IR, NMR and MS respectively. The compound Ⅵ is a new natural product. It wasnamed as comastomaside.     

The Chemical Constituents of Swertia przewalskii Pissjauk.

Seven xanthonenoid compounds and a triterpenic acid have been isolated from Swertia przewalskii Pissjauk. Their structures were identified as 1,8-dihydroxy-3,7-dimethoxyxarthone(Ⅰ), 1,7-dihydroxy-3,8-dimethoxyxanthone (Ⅱ), oleanolic acid (Ⅲ), l-hydroxy-3,7,8-trimethoxyxanthone (Ⅳ), 1,7,8-trihydroxy-3-methoxyxanthone (Ⅴ), 8-0-[β-D-xylopyranosyl-(l--6)-β-D-glucopyranosyl]- 1,7-dihydr0xy- 3-methoxyxanthone (Ⅵ), 1-O- [β-D-xylopyranosyl-(1-6)-β-D-glucopyranosyl]-7,8-dihydroxy- 3-methoxyxanthone (Ⅶ) and 1-O- [β-D-xylopyranosyl-(1-6)-β-D-glucopyranosyl]-8-hydroxy-3,7-dimethoxyanthone (Ⅷ) respectively, by means of chemical and spectral methods or comparing with the authentic samples directly.