Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects

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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

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A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

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Circadian clocks are modulated by compartmentalized oscillating translation

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Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies

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PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation

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Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

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Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption

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A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

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Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

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Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency

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Murine model of colonization with fungal pathogen Candida auris to explore skin tropism,host risk factors and therapeutic strategies

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Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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Deep neural networks identify signaling mechanisms of ErbB-family drug resistance from a continuous cell morphology space

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Lyso-PAF,a biologically inactive phospholipid,contributes to RAF1 activation

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Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1

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A plant immune protein enables broad antitumor response by rescuing microRNA deficiency

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