Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA

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Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

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The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex

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Neurons require glucose uptake and glycolysis in vivo

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PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

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Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

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Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes

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Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth

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Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

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Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

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