Epigenetic dosage identifies two major and functionally distinct β cell subtypes

1. Download : Download high-res image (229KB)
2. Download : Download full-size image

     

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

1. Download : Download high-res image (297KB)
2. Download : Download full-size image

     

The postnatal pancreatic microenvironment guides β cell maturation through BMP4 production

1. Download : Download high-res image (142KB)
2. Download : Download full-size image

     

Soft X-ray tomography to map and quantify organelle interactions at the mesoscale

1. Download : Download high-res image (231KB)
2. Download : Download full-size image

     

Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

1. Download : Download high-res image (131KB)
2. Download : Download full-size image

     

3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk

1. Download : Download high-res image (246KB)
2. Download : Download full-size image

     

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

1. Download : Download high-res image (144KB)
2. Download : Download full-size image

     

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

1. Download : Download high-res image (215KB)
2. Download : Download full-size image

     

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

1. Download : Download high-res image (183KB)
2. Download : Download full-size image

     

An NK-like CAR T cell transition in CAR T cell dysfunction

1. Download : Download high-res image (148KB)
2. Download : Download full-size image

     

Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

1. Download : Download high-res image (175KB)
2. Download : Download full-size image

     

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

1. Download : Download high-res image (219KB)
2. Download : Download full-size image

     

Identification of a LIF-Responsive,Replication-Competent Subpopulation of Human β Cells

1. Download : Download high-res image (164KB)
2. Download : Download full-size image

     

Single-cell transcriptomic and spatial landscapes of the developing human pancreas

1. Download : Download high-res image (307KB)
2. Download : Download full-size image

     

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

1. Download : Download high-res image (149KB)
2. Download : Download full-size image

     

EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas

1. Download : Download high-res image (288KB)
2. Download : Download full-size image

     

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function

1. Download : Download high-res image (167KB)
2. Download : Download full-size image

     

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

1. Download : Download high-res image (113KB)
2. Download : Download full-size image

     

An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells

1. Download : Download high-res image (184KB)
2. Download : Download full-size image

     

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

1. Download : Download high-res image (137KB)
2. Download : Download full-size image