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1.
The new hormonal preparation Physioquens was administered during the study to 181 women during 1.634 cycles and has proved to be very effective in the treatment of various gynaecological disturbances. A definitive reduction has been observed in premenstrual and pre and postmenopausal complaints, dysmenorrhoea, amenorrhoea, intermenstrual pain and endometriosis. Physiquens is also a perfect regulatory device of the cycle in the case of menorrhagia, metrorrhagia and irregular menstrual cycles connected with a hormonal insufficiency. The normophasic treatment with Physioquens is made up of the cyclical administration of a tablet of 0.050 mg ethinyloestradiol for the first 7 days, followed by a tablet of 1 mg lynestrenol and 0.050 mg ethinyloestradiol for the next 15 days. Because of its effectiveness and good tolerance both clinically and biologically Physioquens can be considered an important new step in the treatment of gynaecological problems.  相似文献   

2.
The biological activities of des-octapeptide-insulin, des-AsnA21-des-AlaB30-insulin, des-GlyA1-des-PheB1-insulin and trimethionyl-insulin were studied in vitro and in vivo. In vitro we measured, using the isolated diaphragm of the rat, the disappearance rate of glucose in the incubation medium, the incorporation of glucose into the glycogen of the diaphragm and the apntilipolytic activity in the isolated fat cell model. The incorporation of [U-14C]glucose after intraperitoneal injection into the glycogen of the diaphragm and the fat pad tissue was studied in vivo, as well as the incorporation of 14C from [U-14C]glucose into the lipids of the fat pad tissue of the rat.  相似文献   

3.
Reproduction in female rats kept on artificial cycles of light/darkness, continuous lighting and continuous darkness, has been studied. Three weekly doses of p-chlorophenylalanine (p-CPA), 100 mg/kg, were given to half of the rats in each group during the two preconditioning months before copulation. An evaluation has been made of the insemination, fecundation, number of embryos, ovarian cycle and level of 5-HT in the hypothalamus. The administration of p-CPA had an inhibitory effect on the reproductive behavior, especially pronounced in rats kept under continuous lighting and under continuous darkness. The difference in 5-TH levels were greater among the groups kept on cycles of light/darkness without treatment and with p-CPA (0.05 greater than P greater than 0.01). The importance of 5-HT in the mechanisms of reproductive behavior is emphasized.  相似文献   

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