Effect of aminazine and triftazin on the synaptosome membranes of the rat cerebral cortex

Fluorescent probes 1,6-diphenyl-1,3,5-hexatriene (DPH) and pyrene were employed in studying the effect of aminazine and triftazin versus that of imipramine on microviscosity of rat brain cortex synaptosomal membranes. Unlike imipramine, the neuroleptics decrease microviscosity of membrane's lipid bilayer. All drugs decrease fluorescence of endogenous tryptophan, but fail to change fluorescence of L-tryptophan in the solution. It is concluded that neuroleptics induce conformational perturbations in membrane-bound proteins modifying microviscosity of lipid bilayer whereas imipramine changes the surface electric charge of lipid bilayer of synaptosomal membranes.     

Effects of cerebrocrast on local cerebral circulation and EEG in cats with cerebral hemorrhage]

In experiments on awake cats before and after intracerebral hemorrhage influence of cerebrocrast and nimodipine intravenous infusion (1 microgram/kg-1/min-1 during 60 min) on cerebral blood flow (CBF) in the cortex, thalamus and reticular formation and power of (alpha + beta)-, theta-, and delta-waves was investigated. During cerebrocrast infusion increasing CBF and improving bioelectrical activity were demonstrated.     

Assessment of human regional cerebral circulation by venocclusive rheoplethysmoencephalography]

A possibility was shown of using the method of venocclusion rheoplethysmoencephalography (RPEG) for the assessment of the extent of changes in the cerebral circulation (CC) in individual regions of the cerebral hemispheres of a practically healthy man in various functional loads. The changes in the CC was recorded in per cent in respect to its initial background value. Data on the increase (by 114%) of the CC in the centralparietal region of the left cerebral hemisphere in movement with the right hand and on its reduction (by 45%) in sound stimulation. In the adjacent (temporal) region the changes in the CC were of other character.     

Effect of sodium hydroxybutyrate on cerebral circulation and regional vasomotor reflexes

In experiments on cats it was found using electromagnetic and resistographic methods that sodium hydroxybutyrate (100 mg/kg) considerably increases cerebral circulation. The drug also potentiates the blood flow to the brain during formation of pressor reflexes of the arterial pressure. The blood flow increase is also observed in the system of femoral arteries while in the intestinal artery, on the contrary, there is a reduction in the blood flow increase during vasomotor reflexes. The reflex changes of the resistance in regional vessels are also different: the inhibition of pressor reflexes in the cerebral vessels along with their facilitation in the intestinal and femoral arteries and the potentiation of the reflex dilatatory phase in the limb vessels are seen. Different sensitivity to the drug of synaptic formations in the central links of various regional vasomotor reflexes is likely to underlie the difference described.     

Effect of ornid on the regulation of cerebrovascular circulation]

An investigation of ornid, using radioisotopic, electromagnetic and resistographic methods, has shown the drug to diminish cerebral circulation and to abolish completely the constriction of the brain vessels induced by stimulation of the sympathetic and somatic nerves. Ornid prevented the development of experimental disturbances of the cerebral circulation of adrenergic nature.     

The role of adrenergic structures in the control of cerebral circulation]

A study of the cerebral blood flow carried out by the thermoelectric method demonstrated that stimulation of the cervical sympathetic nerve led to marked changes in the cerebral blood supply. The blood flow changes were two-stage in character: an initial slight increase changed to a decrease below the initial level. Pharmacological analysis with the use of alpha- and beta-adrenoblockers showed a constrictor reaction of the cerebral vessels to be caused by excitation of the alpha-adrenoreactive structures, and the dilatator reaction - by the beta-adrenoreactive structures. An opinion is put forward on a possible mechanism of these changes.     

Effect of Sonne shigella endotoxin on cholinergic regulation of intestinal circulation]

A method of extracorporeal autoperfusion and resistography of the intestinal vessels and synchronous multichannal recording the systemic blood circulation were applied to the study of the influence of the Sh. sonnei endotoxin on the cholinergic regulation of the cardiovascular system in Macacus rhesus. It was shown that development of intoxication was accompanied by the changes in the cholinergic regulation of the intestinal and systemic circulation leading to its disturbance. Possibly affection of the cholinergic control structures and disturbances of the circulation determined the development and the course of the infectious process.