Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap

1. Download : Download high-res image (144KB)
2. Download : Download full-size image

     

Open-state structure and pore gating mechanism of the cardiac sodium channel

1. Download : Download high-res image (216KB)
2. Download : Download full-size image

     

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

1. Download : Download high-res image (286KB)
2. Download : Download full-size image

     

Physical basis for distinct basal and mechanically gated activity of the human K+ channel TRAAK

1. Download : Download high-res image (172KB)
2. Download : Download full-size image

     

Variability of cross-tissue X-chromosome inactivation characterizes timing of human embryonic lineage specification events

1. Download : Download high-res image (236KB)
2. Download : Download full-size image

     

Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales

1. Download : Download high-res image (119KB)
2. Download : Download full-size image

     

High-fidelity encoding of mechanostimuli by tactile food-sensing neurons requires an ensemble of ion channels

1. Download : Download high-res image (115KB)
2. Download : Download full-size image

     

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

1. Download : Download high-res image (358KB)
2. Download : Download full-size image

     

Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites

1. Download : Download high-res image (199KB)
2. Download : Download full-size image

     

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

1. Download : Download high-res image (160KB)
2. Download : Download full-size image

     

Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

1. Download : Download high-res image (223KB)
2. Download : Download full-size image

     

Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus

1. Download : Download high-res image (183KB)
2. Download : Download full-size image

     

Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue

1. Download : Download high-res image (123KB)
2. Download : Download full-size image

     

WeiTsing,a pericycle-expressed ion channel,safeguards the stele to confer clubroot resistance

1. Download : Download high-res image (317KB)
2. Download : Download full-size image

     

In vitro experiments and kinetic models of Arabidopsis pollen hydration mechanics show that MSL8 is not a simple tension-gated osmoregulator

1. Download : Download high-res image (222KB)
2. Download : Download full-size image

     

Molecular sensors for temperature detection during behavioral thermoregulation in turtle embryos

1. Download : Download high-res image (158KB)
2. Download : Download full-size image

     

Conformational changes and CO2-induced channel gating in connexin26

1. Download : Download high-res image (312KB)
2. Download : Download full-size image

     

Balancing cohesin eviction and retention prevents aberrant chromosomal interactions,Polycomb-mediated repression,and X-inactivation

1. Download : Download high-res image (217KB)
2. Download : Download full-size image

     

Structural basis of the partially open central gate in the human CNGA1/CNGB1 channel explained by additional density for calmodulin in cryo-EM map

1. Download : Download high-res image (121KB)
2. Download : Download full-size image

     

Endogenous ligand recognition and structural transition of a human PTH receptor

1. Download : Download high-res image (316KB)
2. Download : Download full-size image